A home-made hybrid system for the simultaneous determination of ergotamine, dipyrone and caffeine in pharmaceutical preparations

Abstract

Um novo sistema híbrido para detecção simultânea de cafeína (CAF), dipirona (DIP) e de ergotamina (ERG) foi desenvolvido para teste de preparações farmaceuticas. ERG foi determinada por um sinal fluorimétrico, enquanto para CAF e DIP foi utilizado o método PLS-1 para resolução de dados espectrométricos de UV-Vis. A curva de calibração da ERG foi linear na faixa de 2.5 -10 mg L for ERG. Sample preparation prior to analysis was not required. A recovery study with the real samples was carried out and the obtained results were highly satisfactory.

Voltammetric Electrode Based on Nafion and Poly(2,3–dihydrothieno–1,4–dioxin)–poly(styrenesulfonate) Film for Fast and High Sensitive Determination of Metamizole

“…Literature is reporting about various methods used for quantitative determining of dipyrone. These mainly include high performance liquid chromatography (HPLC), [4][5][6][7] chemiluminescence, 8,9 NIR spectrometry, 10 amperometry, 11 fluorometry, 12,13 capillary electrophoresis 14 and flow injection analysis with various detection techniques. [15][16][17][18] However many of these methods generate lots of chemical wastes and also require time consuming preparation of sample connected with risk of its contamination.…”