Synthesis of novel PETT analogues: 3,4-dimethoxy phenyl ethyl 1,3,5-triazinyl thiourea derivatives and their antibacterial and anti-HIV studies

Abstract

Derivados de 3,4-dimetóxi-fenil-etil-1,3,5-triazinil tioureias (8a-o e 9a-o) foram preparados pela condensação de 2,4,6-tricloro-1,3,5-s-triazina (1) com 4-hidroxi cumarina (2), 3,4-dimetoxifenil-etil tioureia (4) e várias ureias/tioureias substituídas (6a-o/7a-o), sendo posteriormente testadas com relação a atividade anti-bacteriana e anti-HIV frente a diferentes microorganismos. As estruturas dos compostos sintetizados foram estabelecidas usando-se 1 H RMN, IV e análise elementar.3,4-Dimethoxy phenyl ethyl-1,3,5-triazinyl thiourea derivatives (8a-o and 9a-o) were prepared by condensation of 2,4,6-trichloro-1,3,5-s-triazine (1) with 4-hydroxy coumarin (2), 3,4-dimethoxy phenyl ethyl thiourea (4) and various substituted phenyl urea/thiourea (6a-o/7a-o) and tested for their antibacterial and anti-HIV activities against different microorganisms. The structures of novel synthesized compounds have been established on the basis of 1 H NMR, IR and Elemental Analysis.

Synthesis of 1-Substituted-2-Formamidino-4-Amino-6-Thio1,3,5-Triazines

“…These 1,3,5-triazines have their own identity and importance in medicinal 7 , pharmaceutical 8 , agricultural 9 and industrial 10 fields few of them possesses antidiabetic [11][12] , anti-tumor [13][14][15][16] , anti-inflammatory 17 , anti-depresent 18 , hypoglycaemic 19 activities. They are also used as herbicidal [20][21][22][23][24][25][26] , fungicidal 27-29 , insecticidal 30 , anti-corrosive 31 , antimicrobial 32 and anti-convulsant 33 properties.…”

Synthesis, Structural Elucidation and Anti-Microbial Screening of Benzimidazole Incorporated S-Triazinyl Derivatives

“…Literature survey reveals that substituted s-triazine derivatives are associated with a number of pronounced biological activities [1][2][3][4] . The biological activity is a function of physicochemical properties of the targeted molecule and this assessment is based on the kinds of chemicals that might fit into an active site 5,6 .…”

Design, synthesis, antimicrobial activity and anti-HIV activity evaluation of novel hybrid quinazoline–triazine derivatives

“…Moreover, piperazine heterocycles are valuable structural units in drug research [30][31][32][33][34][35][36] . In context to the above rationale and in continuation of our ongoing program focused on finding new leads with anti-HIV activities [37][38][39][40][41][42] , a novel hybrid series of DATA molecules with a combination of different pharmacophores such as triazine, quinazoline and piperazine that are structurally related to anti-HIV lead compounds, i.e. piperidine linked with DATA-NNRTI derivatives 43 , abacavir having cyclopropyl amine group 44 and DPC 961 45 with quinazoline moiety, are reported ( Figure 2).…”