Synthesis and characterization of platinum(II) complexes from trifluoromethyl phenylenediamine, picoline and N-benzyl ethylenediamine derivatives

Abstract

Este trabalho descreve a síntese e a caracterização de onze novos complexos de platina(II), contendo como ligantes derivados da 1,2-fenilenodiamina, da N-benzil etilenodiamina, e da 2-ou 4-picolina. Os complexos foram preparados em rendimentos satisfatórios pela reação dos ligantes com K 2 [PtCl 4 ]. É descrita também a atividade citotóxica de um dos complexos de platina(II), em sete linhagens de células tumorais de origem humana, que se mostrou muito menos ativo do que a cisplatina.This work describes the synthesis and characterization of eleven new platinum(II) complexes having ligands derived from 1,2-phenylenediamine, N-benzyl ethylenediamine and 2-or 4-picoline. The complexes were prepared in satisfactory yields by reaction of K 2 [PtCl 4 ] with the appropriate ligand. The cytotoxic pre-screening of one of these complexes in seven human cancer cell lines showed that this compound is much less active than cisplatin.

Phase-Change Aminopyridines as Carbon Dioxide Capture Solvents

“…The mixture was allowed to stir a further 30 min at 0 °C, then was allowed to warm to room temperature, and stirred for 6 h. Next, sodium borohydride (5.69 g, 150 mmol) was added in small portions at room temperature, and the mixture was stirred for a further 12 h. The reaction was quenched with a minimum of water until no gas evolved, then the solvent was removed in vacuo. The deep yellow crude mixture was distilled at 110 μm (bp 100–105 °C) to produce 5.94 g of product as a clear light yellow oil (44% yield) …”

“…The deep yellow crude mixture was distilled at 110 μm (bp 100−105 °C) to produce 5.94 g of product as a clear light yellow oil (44% yield). 36 Single-Crystal X-ray Diffraction (XRD). Single crystals for structure determination were held on nylon loop mounts with Paratone oil.…”

Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer ActivityIn Vitro

“…The noticeable activity of the organic ligand could be due to the presence of the piperazinyl moiety. Previous investigation showed that the presence of a strong electron-withdrawing group in the aromatic ring leads to a decrease in the cytotoxic activity of platinum(II) complexes [16].…”

“…Although these complexes were less active than cisplatin, they have showed relevant biological activity against the L1210 leukemic cell lines. de Almeida et al also reported that platinum(II) complexes with ligands derived from 1,2phenylenediamine have potential cytotoxicity [16]. The evaluated compounds were less active in vitro than cisplatin.…”

Synthesis, Characterization, and Cytotoxic Activity of Novel Platinum(II) Complexes Derived from N‐Benzyl‐Ethylenediamine and Oxalate

“…Mononuclear and polynuclear platinum complexes with several different N ‐benzyl derivatives as ligands were previously prepared by our group (19–22). Cytotoxicity activities for these complexes were assessed against different tumor cell lines, both cisplatin resistant and cisplatin non‐resistant.…”