Pyrrolizidine alkaloids from Heliotropium indicum

Abstract

Um novo alcalóide denominado Helindicina (1), e o conhecido licopsamina (2) foram isolados das raízes de Heliotropium indicum (Boraginaceae). As estruturas foram estabelecidas tendo como base um amplo estudo de 1D e 2D RMN (COSY, HMBC, HMQC, NOESY) e HREIMS. Este representa o primeiro relato de um alcalóide contendo um anel lacônico no gênero Heliotropium. Estes alcalóides mostraram moderada atividade antioxidante.Helindicine (1), a new pyrrolizidine alkaloid with unusual structural features, together with the known lycopsamine (2), were isolated from the roots of Heliotropium indicum (Boraginaceae). The structures were established by a combination of 1D and 2D NMR methods (COSY, HMQC, HMBC, and NOESY) and HREIMS. This is the first report of a lactone pyrrolizidine alkaloid in the genus Heliotropium. Compounds 1 and 2 were assayed for antioxidant activity and showed moderate activity.

Normalization of Varus/Valgus Deformities in Osteoarthritis by External Application of Phytoconstituents: Confirmed With Anatomical Observations and Biochemical Profiles and Radiological Images

“…This is a pioneering observation that OA changes in knee joints having varus/valgus deformity can be normalised with the help of previously established medicinal plants [8][9][10][11]. However, only pain and inflammatory disorders have temporarily been relieved, which have been documented by few researchers using these medicinal plants as folk medicine traditionally [31][32][33][34][35][36] but present novel technology is based on aqueous extracts of above-mentioned plants within 42 sittings with specific treatments protocols thrice in a day with application procedure of the above-mentioned phytoconstitutents in especially postural positions of contra lateral and cross contra lateral [8,9].…”

“…The present study, however, is based on aqueous extracts and preserved in sesame oil along with beehive wax as prepared for new treatment protocol [8][9][10][11]. Previous studies have supported the present therapy in respect to anti-inflammatory properties by the presence of phytochemicals in Calotropis gigantea [35,45], muscular pain relief and traditional treatment in osteoarthritis, rheumatoid arthritis and osteoporosis by using organic solvent extracts of Cissus quadrangularis [3,46,47], antioxidant activities by Heliotropium indicum [31] and essential oil from the areal part of plant, Rosemarinus officinalis have showed antiinflammatory, antiproliferative and antioxidant properties [32,48]. Moreover, all the previous studies with these medicinal plants traditionally and/or experimental may have served as temporarily in nature.…”

“…For Heliotropium indicum, whole plant was used. The phytoconstituents such as pyrrolizidine alkaloids (helindicine and lycopsamine), flavonoids and geranyl aromatic derivatives were reported [30,31]. For Rosmarinus officinalis, the leaves and flowers were used.…”

Analyse Qualitative Et Quantitative Des Alcaloïdes Pyrrolizidiniques Chez Quelques Asteraceae, Boraginaceae Et Leguminosae Utilisées En Médecine Traditionnelle En Côte d’Ivoire

“…Au Costa Rica, cette espèce a été incriminée comme la principale cause la plus probable de la mortalité massive observée chez les chevaux due à l'intoxication par des alcaloïdes pyrrolizidiniques de la plante (Van Weeren et al, 1999). La présence du AP chez H. indicum a été rapportée pour un échantillon du Brésil (Souza et al, 2005). A. conyzoides a été reconnue responsable des incidences de problèmes de toxicité liés aux AP en Ethiopie (Wiedenfeld, 2011).…”

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“…This is the first report of a lactone pyrrolizidine alkaloid in the genus Heliotropium. Helindicine and lycopsamine were assayed for antioxidant activity and showed moderate activity 35 .…”