Electrochemical and spectroscopic study of 4-(Phenyldiazenyl)-2-{[tris-(hydroxymethyl)methyl] aminomethylene}cyclohexa-3,5-dien-1(2H)-one: mechanism of the azo and imine electroreduction

Abstract

O composto 4-(fenildiazenil)-2-{[tris(hidroximetil)metil]aminometileno}ciclohexa-3,5-dien-1(2H)-ona foi sintetizado e caracterizado por análise elementar, espectroscopia infravermelho, ressonância magnética nuclear, espectro eletrônico e voltametria cíclica. O equilíbrio tautomérico do 4-(fenildiazenil)-2-{[tris(hidroximetil)metil]aminometileno} ciclohexa-3,5-dien-1(2H)-ona em dimeteilsulfóxido deuterado é comprovado por dados de 1 H RMN. A natureza do processo eletroquímico do 4-(fenildiazenil)-2-{[tris(hidroximetil)metil]aminometileno} ciclohexa-3,5-dien-1(2H)-ona em solução tampão de Britton-Robinson (pH 2-9) foi estudada com o eletrodo gotejante de mercúrio utilizando voltametria de onda quadrada, onda quadrada adsortiva e voltametria cíclica. Os parâmetros eletroquímicos do composto (I p /E p , I p /v, I p /pH, I p /t acc ) foram determinados. methyl]aminomethylene}cyclohexa-3,5-dien-1(2H)-one in Britton-Robinson buffer (pH 2-9) was studied on the HMDE by square-wave (SWV), adsorptive stripping square-wave (AdSWV) and cyclic voltammetry (CV). The electrochemical parameters (I p /E p , I p /v, I p /pH, I p /t acc ) of the compound were determined.

Voltammetry of irbesartan drug in pharmaceutical formulations and human blood: quantification and pharmacokinetic studies

“…22 On the other hand, the N=N group in most organic compounds is known to be reduced much easier than C=N one. [23][24][25] So, considering the reduction potentials of irbesartan over the entire pH range, the reduction behavior of irbesartan on HMDE may be attributed to saturation of the azomethine group C=N in tetrazolyl moiety of irbesartan molecule 26 not to the N=N group which is in contradictory to that reported in literature.…”

Synthesis, Characterization, Quantitative Structure-Activity Relationship, Docking, Antibacterial Activity, and Brine Shrimp Lethal Studies on L-Phenylalanine Schiff Bases

“…The Schiff bases were tested for their inhibitory character on the growth of E. coli, thus bacteria can achieve resistance to antibiotics through morphological and biochemical alterations [29]. The antimicrobial activity was tested by broth dilution method using serially diluted solutions of 25, 12.5, 6.25 µg/ml, respectively.…”

Physicochemical studies and biological activity of mixed ligand complexes involving bivalent transition metals with a novel Schiff base and glycine as a representative amino acid

“…The results of the antimicrobial activities of the synthesized compounds are recorded in Table 4. The biological activity of complexes may be arising from the hydroxyl groups which may play an important role in the antibacterial activity [63]. The mode of action of the compounds may involve formation of a hydrogen bond through the azomethine group (>C=N-) with the active centers of various cellular constituents, resulting in interference with normal cellular processes [64].…”