Thermal decomposition of some chemotherapic substances

Fernandes, Nedja Suely; Filho, Marco Aurélio da Silva Carvalho; Mendes, Roni Antônio; Ionashiro, Massao

doi:10.1590/s0103-50531999000600007

Cited by 41 publications

(19 citation statements)

References 11 publications

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“…Differential scanning calorimetry (DSC) has been recently often used in analysis of medicaments [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. For many years it has been an important tool in the study of drug polymorphism [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Many authors recommend this method for investigation of phase equilibria in multicomponent systems and for detection of inconsistencies between two biologically active substances [8] or between the therapeutic substance and emollients used in drug formulation technology [9][10][11][12]. The DSC method has been also appreciated by the authors working on evaluation of stability of therapeutic substances [13][14][15][16][17][18][19]. It has been successfully applied in estimation of the thermal [13], photochemical [14] and radiochemical stability of drugs [15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

“…The DSC method has been also appreciated by the authors working on evaluation of stability of therapeutic substances [13][14][15][16][17][18][19]. It has been successfully applied in estimation of the thermal [13], photochemical [14] and radiochemical stability of drugs [15][16][17][18][19][20][21]. Determination of the radiochemical stability of therapeutic substances (and emollients) has become of increasing importance in view of growing application of radiation sterilisation, an effective method of sterilisation and decontamination of drugs [22].…”

Section: Introductionmentioning

confidence: 99%

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Thermal study of four irradiated imidazoline derivatives in solid state

Marciniec

Kozak

Naskrent

et al. 2007

J Therm Anal Calorim

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Four imidazoline derivatives: antazoline (AN), naphazoline (NN), tymazoline (TM), xylometazoline (XM), in the form of hydrochlorides in solid phase have been subjected to high energy e-beam irradiation from an accelerator (~10 MeV) at a dose varied from 25 to 200 kGy. The effects of the irradiation have been assessed by DSC, X-ray diffraction, FTIR, EPR and TLC.The standard sterilisation dose of 25 kGy has been found to produce changes in the properties of one derivative (XM), two other ones (AN and TM) have been found sensitive to doses >100 kGy, whereas NN has been resistant to irradiation in the whole range studied (25-200 kGy). EPR results indicated that the changes taking place in the therapeutic substances studied are related to radical formation. The irradiation induced changes in colour, a decrease or increase in the melting point, changes in the XRD pattern, small changes in the shape of FTIR peaks and the presence of radiolysis products. The XM compounds cannot be sterilised by irradiation because of the radiation induced changes in its physico-chemical properties.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thermal study of four irradiated imidazoline derivatives in solid state

Marciniec

Kozak

Naskrent

et al. 2007

J Therm Anal Calorim

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“…However, it can be supposed that CS, cross- linking agent and OTC in cross-linked microcapsules, release small molecular products under more complex thermal degradation behaviour. Thermal analysis of tetracycline hydrochloride [47] showed an endothermic event at 225° and exothermic event at 235°, attributed to a fusion followed by thermal decomposition and oxidation of the evolved products.…”

Section: Resultsmentioning

confidence: 99%

Preparation and Characterization of Cross-Linked Chitosan Microcapsules for Controlled Delivery of Oxytetracycline

Larbi-Bouamrane¹,

Bal²,

Aliouche³

et al. 2016

pharmaceutical-sciences

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Larbi-Bouamrane, et al.: Preparation of Chitosan Microcapsules for Delivery of OxytetracyclineFormulations of encapsulated oxytetracycline in chitosan spherical beads have been developed in this work through the ionotropic gelation method in sodium tripolyphosphate or hexametaphosphate and characterized as drug delivery system to the gastrointestinal tract by Fourier transform infrared spectroscopy, thermal analysis and in vitro drug release in simulated gastric fluids. The Fourier transform infrared spectroscopy and differential scanning calorimetry measurements showed that tripolyphosphate and hexametaphosphate are cross-linked ionically to chitosan and there was no significant drug interaction between the entrapped drug and the carrying polymer. With respect to chitosan cross-linking features, sodium hexametaphosphate seems to give better swelling, higher diffusion and faster release kinetics, while addition of glutaraldehyde as a second cross-linking agent lowers the drug discharge. Release extent and kinetics were found to be pH dependent and approximated very well by the multistep models equations of Makoid-Banakar, PeppasSahlin and Korsmeyer-Peppas. Key words: Oxyteracycline, chitosan, encapsulation, crosslinking, release kineticsTetracyclines are broad spectrum antibiotics that exhibit activity against a wide range of Gram-positive and Gram-negative bacteria. Their favourable antimicrobial properties and the absence of major adverse effects have led to their extensive use in the therapy of human and animal infections [1][2][3][4] . Unfortunately, like the other antibiotic and as a result of the extensive prescription in conventional formulations, the emergence of microbial resistance has limited their effectiveness. So, other strategies are needed to keep tetracycline's and other antibiotics as resources for the next generation and to restore their initial antimicrobial activity. These strategies are based on the development of new classes of drugs with unique antibacterial mechanisms or new formulations enabling the reduction of amounts of antimicrobials used worldwide. In particular, investigation of new formulations has been carried out in order to overcome the disadvantages resulting from the administration of antibiotics in conventional forms [5][6][7] .The specific addressing of active molecules to the organ, tissue or cell is considered now as a major challenge and promising route for the treatment of various human diseases, including bacterial infections, cancer or genetic diseases [8] . New carrying and targeting approaches for drug delivery have been extensively studied in recent years. Most of them are centered on the development of nano-or micro-scale carrying systems [9][10][11] or specific molecules to improve and maximize drug bioavailability and hence therapeutic effects over a period of time. This highly selective approach would ensure an optimum response from the dosage form which significantly lowers the side effects and reduce treatment's expense.As non-conventional pharmaceutical dos...

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“…can also be studied. Several investigations have been carried out on the application of thermal methods in pharmaceutical industry (10)(11)(12)(13)(14)(15) . In present paper, thermal properties of some imidazolinone derivatives have been studied by using TGA technique.…”

Section: Introductionmentioning

confidence: 99%

Thermal Analysis of some Imidazolinone Derivatives

Baluja

Kachhadia

2015

ILCPA

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Thermal analysis of some imidazolinone derivatives derived from 1, N-phenyl-3-p-nitrophenyl-4-formyl pyrazole, have been carried out by TGA technique. From these thermograms, various kinetic parameters such as order of degradation (n), energy of activation (E), frequency factor (A) and entropy change (∆S) have been evaluated. Further, thermal stability of imidazolinone derivatives have been determined, which is found to depend on the type of substituent present in the compounds.

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Thermal decomposition of some chemotherapic substances

Cited by 41 publications

References 11 publications

Thermal study of four irradiated imidazoline derivatives in solid state

Thermal study of four irradiated imidazoline derivatives in solid state

Preparation and Characterization of Cross-Linked Chitosan Microcapsules for Controlled Delivery of Oxytetracycline

Thermal Analysis of some Imidazolinone Derivatives

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