Editorial

Bosi, Alfredo

doi:10.1590/s0103-40142015000100001

Estud. av.

2015

DOI: 10.1590/s0103-40142015000100001

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Editorial

Alfredo Bosi

Abstract: Editorial ste número de estudos avançados abre-se com um dossiê voltado para aspectos da Arqueologia brasileira. A organização dos textos contempla dois eixos semânticos. O eixo conceitual explora a questão da existência e da identidade do que se convencionou chamar "arqueologia brasileira". O eixo temático incide em áreas específicas da pesquisa arqueológica no Brasil: a Amazônia, o Pantanal, as práticas etílicas dos Tupi-Guarani, o povoamento inicial da América do Sul e as paisagens culturais do planalto sul… Show more

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Population-relevant endpoints in the evaluation of endocrine-active substances (EAS) for ecotoxicological hazard and risk assessment

Marty

Blankinship

Chambers

et al. 2017

Integr Environ Assess Manag

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For ecotoxicological risk assessment, endocrine disruptors require the establishment of an endocrine mode of action (MoA) with a plausible link to a population‐relevant adverse effect. Current ecotoxicity test methods incorporate mostly apical endpoints although some also include mechanistic endpoints, subcellular‐through‐organ level, which can help establish an endocrine MoA. However, the link between these endpoints and adverse population‐level effects is often unclear. The case studies of endocrine‐active substances (EAS) (tributyltin, ethinylestradiol, perchlorate, trenbolone, propiconazole, and vinclozolin) evaluated from the Society of Environmental Toxicology and Chemistry (SETAC) Pellston Workshop® “Ecotoxicological Hazard and Risk Assessment Approaches for Endocrine‐Active Substances (EHRA)” were used to evaluate the population relevance of toxicity endpoints in various taxa according to regulatory endocrine‐disruptor frameworks such as the Organisation for Economic Co‐operation and Development (OECD) Conceptual Framework for Testing and Assessment of Endocrine Disruptors. A wide variety of potentially endocrine‐relevant endpoints were identified for mollusks, fish, amphibians, birds, and mammals, although the strength of the relationship between test endpoints and population‐level effects was often uncertain. Furthermore, testing alone is insufficient for assessing potential adaptation and recovery processes in exposed populations. For this purpose, models that link effects observed in laboratory tests to the dynamics of wildlife populations appear to be necessary, and their development requires reliable and robust data. As our understanding of endocrine perturbations and key event relationships improves, adverse population‐level effects will be more easily and accurately predicted. Integr Environ Assess Manag 2017;13:317–330. © 2017 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC)

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Population-relevant endpoints in the evaluation of endocrine-active substances (EAS) for ecotoxicological hazard and risk assessment

Marty

Blankinship

Chambers

et al. 2017

Integr Environ Assess Manag

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Review and analysis of the potential for glyphosate to interact with the estrogen, androgen and thyroid pathways

Levine

Webb

Saltmiras

2020

Pest Management Science

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Glyphosate was recently evaluated for its potential to interact with the estrogen, androgen and thyroid (EAT) hormone pathways, including steroidogenesis, under the United States Environmental Protection Agency's (USEPA) Endocrine Disruptor Screening Program (EDSP), then by Germany, the rapporteur Member State who led the European Annex 1 renewal for glyphosate, and then by the European Food Protection Agency (EFSA) also as part of the Annex 1 renewal for glyphosate. Under the EDSP, 11 Tier 1 assays were run following the USEPA's validated 890‐series test guidelines and included five in vitro and six in vivo assays to evaluate the EAT pathways. Steroidogenesis was evaluated as part of the estrogen and androgen pathways. An up‐to‐date critical review has been conducted that considered results from the EDSP Tier 1 battery, guideline regulatory studies and an in‐depth analysis of the literature studies that informed an endocrine assessment. A strength of this evaluation was that it included data across multiple levels of biological organization, and mammalian and nonmammalian test systems. There was strong agreement across the in vitro and in vivo Tier 1 battery, guideline studies and relevant literature studies, demonstrating that glyphosate does not interact with EAT pathways including steroidogenesis. Based on an analysis of the comprehensive toxicology database for glyphosate and the literature, this review has concluded that glyphosate does not have endocrine‐disrupting properties through estrogen, androgen, thyroid and steroidogenic modes of action. © 2020 Society of Chemical Industry

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Study of nanomechanical properties of (1- y )BST- y MgO thin films

Czekaja

Lisińska-Czekaj

Plewab

2017

Ciência & Tecnologia dos Materiais

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Editorial

Cited by 8 publications

References 0 publications

Population-relevant endpoints in the evaluation of endocrine-active substances (EAS) for ecotoxicological hazard and risk assessment

Population-relevant endpoints in the evaluation of endocrine-active substances (EAS) for ecotoxicological hazard and risk assessment

Review and analysis of the potential for glyphosate to interact with the estrogen, androgen and thyroid pathways

Study of nanomechanical properties of (1- y )BST- y MgO thin films

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