Lipoprotein (a) and cardiovascular risk factors in children and adolescents

Palmeira, Ástrid Camêlo; Leal, Adriana Amorim de Farias; Ramos, Nathaly de Medeiros N.; Neto, José de Alencar F.; Simões, Mônica Oliveira da Silva; Medeiros, Carla Campos Muniz

doi:10.1590/s0103-05822013000400017

Cited by 10 publications

(7 citation statements)

References 18 publications

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“…Additional and independent risk factor for CHD is represented by high lipoprotein (a) [Lp(a)] levels, studied in several patient groups [159][160][161]. The association between its plasma levels and the condition of childhood obesity is unclear [162]. Glowinska et al [163] studied lipid profiles in obese, hypertensive and diabetic young patients showing significant changes in lipid metabolism, including Lp(a), apolipoprotein A (Apo A) and Apo B levels.…”

Section: Cardiovascular Riskmentioning

confidence: 99%

Childhood obesity: an overview of laboratory medicine, exercise and microbiome

Scudiero

Pero

Ranieri

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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In the last few years, a significant increase of childhood obesity incidence unequally distributed within countries and population groups has been observed, thus representing an important public health problem associated with several health and social consequences. Obese children have more than a 50% probability of becoming obese adults, and to develop pathologies typical of obese adults, that include type 2-diabetes, dyslipidemia and hypertension. Also environmental factors, such as reduced physical activity and increased sedentary activities, may also result in increased caloric intake and/or decreased caloric expenditure. In the present review, we aimed to identify and describe a specific panel of parameters in order to evaluate and characterize the childhood obesity status useful in setting up a preventive diagnostic approach directed at improving health-related behaviors and identifying predisposing risk factors. An early identification of risk factors for childhood obesity could definitely help in setting up adequate and specific clinical treatments.

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Section: Cardiovascular Riskmentioning

confidence: 99%

Childhood obesity: an overview of laboratory medicine, exercise and microbiome

Scudiero

Pero

Ranieri

et al. 2019

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…34 Recent evidence indicates that children and adolescents with high ApoB and low ApoA1 concentrations may show signs of atherosclerosis at earlier ages than those of the same age with normal concentrations of these biochemical parameters. 35 Scientific evidence highlights that exposure to these risk factors in the first cycles of life can contribute to the development of cardiovascular changes in later periods of life. 31,36…”

Section: Discussionmentioning

confidence: 99%

Adiposidade Corporal e Apolipoproteínas em Crianças e Adolescentes: Metanálise de Estudos Prospectivos

Jesus¹,

Costa²,

Oliveira³

et al. 2020

Arquivos Brasileiros De Cardiologia

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Background: Excess Weight and Cardiovascular Diseases are health problems with increasing prevalence among children and adolescents, hence the need to investigate the issues related to them to better deal with the problem. Objective: To investigate the influence of excess adiposity on the levels of apolipoprotein B and A1 in children and adolescents. Methods: A systematic search was conducted in the PubMed, Embase, Lilacs, Web of Science, Ovid and Science direct databases, searching for cohort eligible studies and evaluating their results, methodological quality and risk of bias; combinable studies with good quality and low risk of bias were evaluated by meta-analysis. The summary measure used was the weighted mean difference (WMD) with its respective 95% confidence interval. Results: 8 articles attended the eligibility criteria including individuals with age mean varying from 9 to 15.7 years of age. The meta-analysis included 4 articles with a total of 7,974 children and adolescents. It was observed a mean increase of 4,94mg/dL (95%CI: 4,22 to 5,67) in the ApoB levels in individuals with excess of body adiposity. For the ApoA1, we identified a mean reduction of-8,13mg/dL (95%CI:-9,09 to-7,17 mg/dL) in its levels in children and adolescents with higher body adiposity. Beside this, the influence of excess adiposity on the ApoB and ApoA1 levels was higher between adolescents than children. Conclusions: The excess of body adiposity influenced both the reduction of ApoA1 values and the increase of ApoB levels, being these changes more relevant among adolescents.

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“…Aquí, se observó que los individuos con concentraciones altas de estradiol mostraban concentraciones bajas de triglicéridos y c-VLDL. Evidencia científica muestra que los estrógenos tienen una amplia variedad de efectos sobre el perfil de lípidos en hombres y mujeres (19,21), y se describen cambios significativos en los niveles de lípidos en suero y de lipoproteínas durante la pubertad (38)(39)(40)(41).…”

Section: Discussionunclassified

Niveles de estradiol en niños y jóvenes y su relación con género, edad, presión arterial, lípidos plasmáticos y polimorfismo XbaI del receptor de estrógenos.

et al. 2018

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La identificación de factores de riesgo para las enfermedades cardiovasculares (ECV) puede ayudar a prevenir su desarrollo. Las hormonas esteroides a través de sus receptores y las variaciones genéticas influyen sobre el metabolismo de los lípidos y la presión arterial, entre otras funciones. Métodos: Estudio descriptivo realizado en niños y adolescentes entre 8 y 18 años de edad. Objetivo: Determinar los niveles de estradiol y su relación con género, edad, presión arterial, lípidos plasmáticos y polimorfismo XbaI del receptor de estrógenos. Resultados: No se encontró relación estadística entre el polimorfismo XbaI y las concentraciones de estradiol, pero sí entre el polimorfismo y el perfil lipídico, de igual manera entre las concentraciones de esta hormona con triglicéridos y c-VLDL. Conclusión: Este trabajo evidencia la relación entre niveles de estrógenos, edad, presión sanguínea y lípidos plasmáticos, de igual forma demuestra una relación entre polimorfismo XbaI del ESR1 y los niveles de lípidos.

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Lipoprotein (a) and cardiovascular risk factors in children and adolescents

Cited by 10 publications

References 18 publications

Childhood obesity: an overview of laboratory medicine, exercise and microbiome

Childhood obesity: an overview of laboratory medicine, exercise and microbiome

Adiposidade Corporal e Apolipoproteínas em Crianças e Adolescentes: Metanálise de Estudos Prospectivos

Niveles de estradiol en niños y jóvenes y su relación con género, edad, presión arterial, lípidos plasmáticos y polimorfismo XbaI del receptor de estrógenos.

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