Lack of difference between continuous versus intermittent heparin infusion on maintenance of intra-arterial catheter in postoperative pediatric surgery: a randomized controlled study

Witkowski, Maria Carolina; Moraes, Maria Antonieta; Firpo, Cora

doi:10.1590/s0103-05822013000400015

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Heparin is an anticoagulant drug used to prevent and treat thrombosis ( 5 ). Unfractionated heparin is a standard anticoagulant that affects multiple sites of internal and external coagulatory system and inhibits blood clotting ( 6 , 7 ). Heparin, even with low dose, can cause thrombocytopenia and bleeding ( 8 - 10 ).…”

Section: Introductionmentioning

confidence: 99%

Heparinized and Saline Solutions in the Maintenance of Arterial and Central Venous Catheters After Cardiac Surgery

et al. 2015

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Background:Heparinized saline solution is used to prevent occlusion in the arterial catheters and central venous pressure monitoring catheters. Even at low dose, heparin administration can be associated with serious complications. Normal saline solution can maintain patency of arterial catheters and central venous pressure monitoring catheters.Objectives:The current study aimed to compare the efficacy of normal saline with that of heparinized one to maintain patency of arterial and central venous catheters after cardiac surgery.Patients and Methods:In the current randomized controlled trial, 100 patients, with an age range of 18 - 65 years of valve and coronary artery surgery were studied in Rajaie heart center, Tehran, Iran. Patients were randomized to receive either heparinized saline (n = 50) or normal saline flush solutions (n = 50). In the study, arterial catheters and central venous pressure monitoring catheters were daily checked for any signs of occlusion in three postoperative days as primary end-point of the study.Results:According to the information obtained from the study, four (8%) arterial catheters in the saline group (P value: 0.135) and three (6%) arterial catheters in the heparin group (P value = 0.097) were obstructed. Statistical analysis showed that the incidence of obstruction and changes in all other parameters between the two groups during the three-day follow-up was not significant (all P values > 0.05).Conclusions:It seems that there is no difference in the use of heparinized and normal saline solutions to prevent catheter occlusion of arterial and central venous pressure.

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Section: Introductionmentioning

confidence: 99%

Heparinized and Saline Solutions in the Maintenance of Arterial and Central Venous Catheters After Cardiac Surgery

et al. 2015

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“…Heparin is an anticoagulant drug used to prevent and treat thrombosis [4]. Unfractionated heparin is a standard anticoagulant that affects multiple sites of internal and external coagulatory system and inhibits blood clotting [5]. Heparin administration can be associated with serious complications.…”

Section: Original Research Articlementioning

confidence: 99%

To Evaluate the Effect between Normal Saline and Heparin Solution in Arterial Line Flushing on Platelet Count – A Cross Sectional Study

Hossain¹,

Reza²,

Hossain³

et al. 2022

Glob Acad J Med Sci

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Introduction: Arterial catheters are widely used in intensive care units for continuous blood pressure monitoring and blood sampling. The patency of these lines is maintained by continuous flushing, usually with the addition of the anticoagulant heparin to the flushing solution. Normal saline solution can maintain patency of arterial and central venous pressure monitoring catheters. Aim of the Study: The aim of this study was to evaluate the effect between normal saline and heparin solution in arterial line flushing on platelet count. Methods: This was a prospective cross- sectional study conducted in the Department of Cardiac surgery of National Institute of Cardiovascular Disease (NICVD), Sher-E-Bangla Nagar, Dhaka, Bangladesh during the period from July 2016 to June 2017. This study included sixty patients who underwent single valve replacement surgery and shifted to the ICU with arterial line catheter. The patients who fulfilled the inclusion criteria were divided into two groups- Group A (with heparin solution) and Group B (with normal saline). Result: In total 60 patients from both the groups completed the study. In our study we found the mean ± SD of age among group A & B was (36.3±6.7) & (35.7±10.3) respectively. We found the mean± SD of platelet count at 1st POD was (206530±64441) & (212543±48768); at 3rd POD was (226517±60185) & (245957±52826); at 7th POD was (240517±57379) & (257713±53655); at 14th POD was (245850±52680) & (244337±56796) in Group A & B respectively. Conclusion: In our study we didn’t find any statistically significant difference regarding the patients’ demographic characteristics and there were no statistically significant difference of platelet counts between Group A and Group B at preoperative period, post pump, 1st POD, 2nd POD, 3rd POD, 4th POD, 7th POD and 14th POD.

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“…4 Unfractionated heparin is a standard anticoagulant that affects multiple sites of internal and external coagulatory system and inhibits blood clotting. 5 Heparin administration can be associated with serious complications. It has a number of drug interactions, as well as potentially serious side effects.…”

mentioning

confidence: 99%

Role of Heparin in Arterial Line Flushing Solution on Platelet Count and Indwelling Arterial Catheter Patency after Cardiac Valvular Surgery

et al. 2018

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Background: Heparin can cause thrombocytopenia but what is it's effect on platelet when used in solution forflushing indwelling arterial catheter is not clear. This study was designed to find out any effect of heparin on platelet count and to see the efficacy of normal solution as flushing solution. Method:Thiswas a prospective randomized comparative clinical trial in the Bangladesh during the period from july 2016 to june 2017. Total sixty patients who underwent single valve replacement surgery were divided into two groups and were evaluated for heparin effect and compared for arterial catheter patency rate. Results: Platelet count on third postoperative day is 226517+-60185/ml and 245957+-52826/ml in heparinized flush solution and normal saline flush solution group respectively. The difference of mean is not significant with p value 0.188. Arterial catheter patency rate was 50.0% in heparinized flush solution group and 43.3% in normal saline flush solution group on third postoperative day which signifies no difference between the groups with p value 0.607. Conclusion: The use of heparin in normal saline in continuous flushing devices for an arterial catheter does not significantly reduce platelet counts in cardiac valve surgery patients in comparison to normal saline. It seems that there is no difference in the use of heparinized and normal saline solutions to maintain indwelling arterial catheter patent.

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Lack of difference between continuous versus intermittent heparin infusion on maintenance of intra-arterial catheter in postoperative pediatric surgery: a randomized controlled study

Cited by 3 publications

References 21 publications

Heparinized and Saline Solutions in the Maintenance of Arterial and Central Venous Catheters After Cardiac Surgery

Heparinized and Saline Solutions in the Maintenance of Arterial and Central Venous Catheters After Cardiac Surgery

To Evaluate the Effect between Normal Saline and Heparin Solution in Arterial Line Flushing on Platelet Count – A Cross Sectional Study

Role of Heparin in Arterial Line Flushing Solution on Platelet Count and Indwelling Arterial Catheter Patency after Cardiac Valvular Surgery

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