Metabolismo de glicose em gêmeos monozigóticos discordantes para aptidão cardiorrespiratória

Queiróga, Marcos Roberto; Barbieri, Ricardo Augusto; Ferreira, Sandra Aires; Luchessi, André Ducati; Silbiger, Vivian Nogueira; Hirata, Rosário Dominguez Crespo; Hirata, Mário Hiroyuki; Kokubun, Eduardo

doi:10.1590/s0103-05822013000100013

Cited by 3 publications

(5 citation statements)

References 29 publications

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“…Fifty-four twin pairs (35 girls and 19 boys) attended clinical and evaluation sessions. Parental testing by microsatellite analysis was performed as previously described [ 23 ] and revealed that the sample evaluated had 38 MZ twin pairs and 16 dizygotic (DZ) twin pairs. In the study, only MZ twin pairs were included (24 girls and 14 boys, 14.3 ± 2.1 years old; 51.4 ± 12.9 kg; 158.2 ± 10.6 cm).…”

Section: Methodsmentioning

confidence: 99%

“…Microsatellite analysis was carried out by PCR using the Identifiler commercial kit, according to the manufacturer's instructions (Applied Biosystems, Foster City, EUA). This assay allows the genotyping of 15 multiple informative genetic markers (CSF1PO, D2S1338, D3S1358, D7S820, D8S1179, D13S317, D16S539, D18S51, D19S433, D21S11, D5S51, FGA, TH01, TPOX, VWF, and AMELXloci), which allows for the identification of monozygotic and dizygotic twins [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

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Influence of Cardiorespiratory Fitness onPPARGmRNA Expression Using Monozygotic Twin Case Control

Queiróga

Barbieri

Ferreira

et al. 2015

Journal of Diabetes Research

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The influence of cardiorespiratory fitness (VO2max) on anthropometric variables and PPARG mRNA expression was investigated. Monozygotic twin pairs aged 11–18 years were grouped into discordant (D) and concordant (C) high and low VO2max groups. VO2max was determined by progressive maximal exercise test on treadmill with gas exchange analysis. Body mass (BM), BMI, waist circumference (WC), triceps (TR), and subscapular (SB) skinfold thicknesses were measured. Twins from the discordant group had differences in VO2max values (D-high = 45.9 ± 10.0 versus D-low = 32.4 ± 10.6 mL·kg−1·min−1, P = 0.025), while no differences were found in the concordant group (C-high = 42.4 ± 9.2 versus C-low = 38.8 ± 9.8 mL·kg−1·min−1, P = 0.952). In discordant group, VO2max was negatively correlated with TR + SB (r = −0.540, P = 0.021) and positively correlated with PPARG expression in leukocytes (r = 0.952, P = 0.001). Moreover, PPARG expression was directly correlated with BM (r = 0.714, P = 0.047) and height (r = 0.762, P = 0.028). In concordant twins, VO2max was inversely correlated with BM (r = −0.290, P = 0.027), BMI (r = −0.472, P = 0.001), WC (r = −0.426, P = 0.001), and TR + SB (r = −0.739, P = 0.001). Twins D-high had 1.78-fold greater PPARG expression when compared with twins D-low (P = 0.048). In conclusion, the cardiorespiratory fitness may modulate PPARG expression in childhood and adolescence, independently of the genetic background.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Influence of Cardiorespiratory Fitness onPPARGmRNA Expression Using Monozygotic Twin Case Control

Queiróga

Barbieri

Ferreira

et al. 2015

Journal of Diabetes Research

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“…There is evidence that the best cardiorespiratory fitness caused by physical exercise exhibits a dose-response relationship, implying improvements in the lipid and glycemic profiles and body composition, as well as generating general health benefits (Dias et al, 2011;McKinney et al, 2016;Oliveira et al, 2014). Queiroga et al (2013) demonstrated that MZ twins discordant for cardiorespiratory fitness presented differences in glycemic metabolism, regardless of genetic factors. However, despite the significant number of studies that have analyzed these factors, few studies have used twins discordant for physical exercise and evaluated the effects on metabolic risk factors (Queiroga et al, 2013).…”

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confidence: 98%

“…Queiroga et al (2013) demonstrated that MZ twins discordant for cardiorespiratory fitness presented differences in glycemic metabolism, regardless of genetic factors. However, despite the significant number of studies that have analyzed these factors, few studies have used twins discordant for physical exercise and evaluated the effects on metabolic risk factors (Queiroga et al, 2013).…”

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confidence: 98%

“…Cardiorespiratory fitness is seen as a variable with significant genetic effects (50%−67%; Bouchard et al, 1999;Miyamoto-Mikami et al, 2018); however, it is also influenced by factors such as age, sex and level of physical activity (Queiroga et al, 2013). There is evidence that the best cardiorespiratory fitness caused by physical exercise exhibits a dose-response relationship, implying improvements in the lipid and glycemic profiles and body composition, as well as generating general health benefits (Dias et al, 2011;McKinney et al, 2016;Oliveira et al, 2014).…”

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confidence: 99%

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Metabolic Profile and Body Composition in Twins Concordant and Discordant for Physical Exercise

et al. 2020

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The aim of this study was to evaluate the differences in the metabolic profile and body composition of monozygotic (MZ) twins concordant and discordant for the practice of physical exercise. The sample consisted of 92 MZ twins (72.5% female and 27.5% male, mean age 25.4 ± 5.69 years), registered with the Brazilian Registry of Twins, residing in Natal, Brazil. Data collection was carried out between the years 2016 and 2018. On day 1, subjects underwent a whole-body fitness evaluation, including measures of weight, height, body composition by Dual-Energy X-ray Absorptiometry and the Cardiorespiratory Exercise Test. On day 2, 10 ml blood samples were collected (overnight fasting) to determine the lipid profile and fasting glucose. The sample was separated into three groups: Active Concordant twins (Concordant A, n = 44 subjects), Inactive Concordant twins (Concordant I, n = 22 subjects) and Discordant pairs for Physical Exercise (Discordant PE, n = 26 subjects). The results demonstrated a difference between the discordant twins for exercise and also between the active versus sedentary groups, indicating a causal effect of exercise on the fat percentage, maximum oxygen consumption (VO2max) and second ventilatory threshold variables. Between groups, a difference was also observed between the groups in ventilatory threshold, very low-density lipoprotein and triglycerides. We concluded that, regardless of genetics, the practice of physical exercise was sufficient to generate alterations in body composition and VO2max in MZ twins, but not in the lipid profile or fasting glucose.

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Validity of Physical Activity Measures in Individuals After Total Knee Arthroplasty

Almeida

Wert

Brower

et al. 2015

Archives of Physical Medicine and Rehabilitation

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OBJECTIVE To determine the concurrent criterion-related validity of two activity monitors in comparison to the criterion method of indirect calorimetry in older adults after total knee arthroplasty (TKA). DESIGN Validation study. SETTING Subjects completed 9 increasingly demanding daily activities in a research laboratory; each activity was performed for 7 minutes, for a total of 80-minutes while the activity monitors and criterion method were used concurrently. PARTICIPANTS Twenty-one subjects, 67% female, mean age 68±7 years old, and BMI 29±4. INTERVENTIONS not applicable. MAIN OUTCOME MEASURE Energy expenditure (EE) in kcal/min measured by accelerometer-based and multisensor-based monitors, and the criterion method. Validity was assessed by paired t-test, intra-class correlation coefficient (ICC), and Bland-Altman plots comparing the measurements from the activity monitors to the criterion method. RESULTS Measurements from the accelerometer-based monitor were significantly lower than those of the criterion method across all walking and non-walking activities. The underestimations ranged from 40% to 100%. The accelerometer-based monitor demonstrated small to moderate agreement compared to the criterion method (ICCs from 0 to 0.38). Measurements from the multisensor-based monitor were significantly lower than the criterion method during several non-walking activities; yet, the differences were minor (2% to 19%). Measurements from the multisensor-based monitor during walking activities were not different compared to the criterion method. The multisensor-based monitor demonstrated moderate to excellent agreement with the criterion method (ICCs from 0.48 to 0.81). CONCLUSION The multisensor-based monitor showed better criterion-related validity than the accelerometer-based monitor, and should be considered as a tool to measure physical activity in individuals after TKA.

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Metabolismo de glicose em gêmeos monozigóticos discordantes para aptidão cardiorrespiratória

Abstract: In this case-control study (discordant monozygotic twins), the less active co-twins were characterized by higher fasting plasma glucose levels. This implies that poor cardiorespiratory fitness can be associated with defective glucose metabolism regardless of genetic factors.

Cited by 3 publications

References 29 publications

Influence of Cardiorespiratory Fitness onPPARGmRNA Expression Using Monozygotic Twin Case Control

Influence of Cardiorespiratory Fitness onPPARGmRNA Expression Using Monozygotic Twin Case Control

Metabolic Profile and Body Composition in Twins Concordant and Discordant for Physical Exercise

Validity of Physical Activity Measures in Individuals After Total Knee Arthroplasty

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