Peculiaridades da terapia trombolítica na síndrome nefrótica pediátrica: monitorização do fator anti-Xa

Meirelles, Patrícia Zambi; Watanabe, Andréia; Carneiro, Jorge David Aivazoglou; Koch, Vera H.

doi:10.1590/s0103-05822008000200015

Cited by 2 publications

(1 citation statement)

References 16 publications

(7 reference statements)

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“…No published INS-specific optimal AT target levels exist, although a small case series shows the effective use of recombinant AT in adults with congenital AT during the peri-operative period [ 119 ]. In children with INS, titrating LMWH therapy to anti-Xa levels can result in more effective anticoagulation [ 120 ]. As yet no data regarding the use of new oral anticoagulants exist specifically for children with INS, although this is a promising possibility for future management [ 121 ].…”

Section: Thromboembolic Diseasementioning

confidence: 99%

The non-immunosuppressive management of childhood nephrotic syndrome

2015

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Idiopathic nephrotic syndrome (INS) is one of the most common renal diseases found in the paediatric population and is associated with significant complications, including infection and thrombosis. A high proportion of children enter sustained remission before adulthood, and therapy must therefore mitigate the childhood complications, while minimising the long-term risk to health. Here we address the main complications of INS and summarise the available evidence and guidance to aid the clinician in determining the appropriate treatment for children with INS under their care. Additionally, we highlight areas where no consensus regarding appropriate management has been reached. In this review, we detail the reasons why routine prophylactic antimicrobial and antithrombotic therapy are not warranted in INS and emphasise the conservative management of oedema. When pharmacological intervention is required for the treatment of oedema, we provide guidance to aid the clinician in determining the appropriate therapy. Additionally, we discuss obesity and growth, fracture risk, dyslipidaemia and thyroid dysfunction associated with INS. Where appropriate, we describe how recent developments in research have identified potential novel therapeutic targets.

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Section: Thromboembolic Diseasementioning

confidence: 99%

The non-immunosuppressive management of childhood nephrotic syndrome

2015

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Carotid intima media thickness in children with nephrotic syndrome: an observational case control study

et al. 2019

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Carotid intima media thickness (cIMT) is considered as a surrogate marker for the various cardiovascular events that complicate nephrotic syndrome (NS). The present work was conducted to study cIMT in children with NS and to find out its correlation with dyslipidemia and other risk factors. This was a case control study conducted at a tertiary care hospital in children with NS who were more than 2 years with normal serum complement, being on therapy for NS for at least 1 year, glomerular filtration rate more than 90 ml/minute/1.73 m 2 and absence of acute infection in previous 3 months. Sixty six children with NS constituted the case material and 128 age and sex matched children were taken as control. The mean age in case and control cohort was 6.71 ± 3.3 and 7.89 ± 3.95 years, respectively. The mean age of onset of illness was 4.32 ± 2.25 years. The mean duration of illness was 2.39 ± 1.44 years. Thickness of cIMT was higher in NS children as compared to control group in all the ages, but this difference was statistically significant only after 4 years of age. There was statistically significant, but weak positive correlation between cIMT and age of NS children, duration of disease and number of relapses. There was no correlation of cIMT with hypertension, body mass index, serum creatinine, and dyslipidemia. A negative, but statistically insignificant correlation of cIMT was found with serum albumin and serum cholesterol.

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Peculiaridades da terapia trombolítica na síndrome nefrótica pediátrica: monitorização do fator anti-Xa

Cited by 2 publications

References 16 publications

The non-immunosuppressive management of childhood nephrotic syndrome

The non-immunosuppressive management of childhood nephrotic syndrome

Carotid intima media thickness in children with nephrotic syndrome: an observational case control study

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