Antibacterial properties and healing effects of Melipona scutellaris honey in MRSA-infected wounds of rats

Medeiros, Vanessa de Fátima Lima Paiva; Azevedo, Ítalo Medeiros; Rêgo, Amália Cínthia Meneses; Egito, Eryvaldo Sócrates Tabosa do; Araújo‐Filho, Irami; Medeiros, Aldo Cunha

doi:10.1590/s0102-865020160050000006

Cited by 15 publications

(13 citation statements)

References 22 publications

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“…Moreover, a study done by Kimoto-Nira and Amano (2008) proved that stingless bee honey able to protect against gastrointestinal infection in humans. Due to the emerging of the antibiotic resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA), the potential of the honey to become an antibacterial agent to against this problem were proved by studies done by and Medeiros et al (2016).…”

Section: Trigona Incisa Trigona Apicalis T Fuscobalteata T Fuscimentioning

confidence: 99%

“…The inhibition zones generated by the honey samples ranged from 20mm to 27 mm and MIC values ranged from 0.62 to 1 2.5%. Medeiros et al (2016) MRSA-infected wounds of rats (n= 24)…”

Section: Conflict Of Interestmentioning

confidence: 99%

“…Previous study showed that stingless bee honey can act as anti-inflammatory (Borsato et al, 2014), anticancer (Kustiawan et al, 2014;Yazan et al, 2016), antimicrobial (Miorin et al, 2003;Demera et al, 2004;Garedew et al, 2004;Temaru et al, 2007;Kimoto-Nira and Amano, 2008;Chanchao et al, 2009;Boorn et al, 2010;Rodríguez et al, 2012;Ilechie et al, 2012;Andualem, 2013;Ewnetu et al, 2013;Mercês et al, 2013;Queiroz et al, 2013;Zainol et al, 2013;Nobre da Cruz et al, 2014;Massaro et al, 2014;Zamora et al, 2014;Medeiros et al, 2016;De Sousa et al, 2016; and possessed antioxidant properties (Duarte et al, 2012;Almeida da Silva et al, 2013;De Sousa et al, 2016). However, the beneficial of stingless bee honey has been abandoned in modern medicine due to the paucity of systematic scientific studies for supporting its medical properties (Pe´rez et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…The color of the honey is usually clearer, liquid and has a sweet and sour taste (Roowi et al, 2012). The recent studies showed that the stingless bee honey has the potential to treat colorectal cancer (Yazan et al, 2016), anti-inflammatory (Borsato et al, 2014), antimicrobial (Zainol et al, 2013;Nobre da Cruz et al, 2014;Massaro et al, 2014;Medeiros et al, 2016;De Sousa et al, 2016; and has an antioxidant property (Almeida Da Silva et al, 2013;Duarte et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Stingless bee honey and its potential value: a systematic review

Yaacob

Rajab²,

Shahar³

et al. 2017

Food Res.

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Modern science has found that most traditional practice of using stingless bee honey has great potential as an added value in modern medicine and considered to have a higher medicinal value than other bee species. However, due to the relatively low output of honey compared to other honey so, focus on this honey is limited. Hence, this systematic review provides the updated result on the potential value of stingless bee honey as an antioxidant, anti-inflammatory, cytotoxicity and antimicrobial. The search strategy was developed in four databases (Scopus, Medline and Ovid, EMBASE and PubMed) with the search terms "("honey" and "Kelulut", "honey" and "stingless bee", "honey" and "Trigona", "honey" and "pot honey", and "honey" and "Melipon")". The merged data was assessed using PRISMA guidelines and after the duplicates were removed, 1271 articles were segregated. Afterwards, 1232 articles were eliminated because they do not meet the inclusion criteria and 39 articles were reevaluated again for eligibility. Finally, after the evaluation process, only 26 of the articles were chosen for this review. The data of 26 articles of stingless bee honey were deliberated based on antioxidant properties, anti-inflammatory, cytotoxicity and analysis of antimicrobial activity. Three articles reported on antioxidant properties, one article on anti-inflammatory analysis, two articles on cytotoxicity analysis, and twenty articles on analysis of antimicrobial activity. Based on the feasible affirmation from the literature, stingless bee honey has an antioxidant capacity that able to decrease the ROS. ROS able to lead a variety of health problems thus stingless bee honey can be a dietary supplement to overcome this problem.

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Section: Trigona Incisa Trigona Apicalis T Fuscobalteata T Fuscimentioning

confidence: 99%

“…The inhibition zones generated by the honey samples ranged from 20mm to 27 mm and MIC values ranged from 0.62 to 1 2.5%. Medeiros et al (2016) MRSA-infected wounds of rats (n= 24)…”

Section: Conflict Of Interestmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stingless bee honey and its potential value: a systematic review

Yaacob

Rajab²,

Shahar³

et al. 2017

Food Res.

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“…Efective inhibition of growth of MRSA isolates has been revealed in the case of mentioned above Chilean honey obtained from Ulmo tree [32], Malaysian melaleuca honey [35], some Thai honeys, especially from longan lower [36], Finland [37] and also many other geographical regions. Moreover, some authors revealed high activity of honey in eradication MRSA infections using in vivo models [38]. Considering honey as a therapeutic, antimicrobial agent the honey produced from the manuka bush (Leptospermum scoparium) indigenous to New Zealand and Australia deserves special atention.…”

Section: Honey As a Potential Antistaphylococcal Agentmentioning

confidence: 99%

Bee Products and Essential Oils as Alternative Agents for Treatment of Infections Caused by S. aureus

Szweda¹,

Kot²

2017

Frontiers in Staphylococcus Aureus

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Bacteria of the genus Staphylococcus are important human and veterinary pathogens. A crucial characteristic for this group of bacteria is that they can easily acquire mechanisms of antibiotic resistance for a plethora of antibiotics currently in use for human and animal therapies. Therefore, there is a great need to ind novel, non-antibiotic chemotherapeutics with marked antistaphylococcal activity. Promising but still underestimated group of potential antistaphylococcal chemotherapeutics constitute bee products: honey, pollen, royal jelly, fermented pollen and especially propolis. Another group of natural products that exhibit promising antibacterial activity is essential oils. Usefulness of bee products and essential oils in the treatment of infections caused by S. aureus has been conirmed by results of many investigations carried out by researches in diferent regions of the world. In this chapter, we have presented the review of publication in this area as well as perspectives and limitations of future applications of these two groups of natural products.

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The effects of honey on pro‐ and anti‐inflammatory cytokines: A narrative review

Navaei-Alipour

Mastali

Ferns

et al. 2021

Phytotherapy Research

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Honey contains flavonoids and phenolic acids, and because of their antioxidant and anti-inflammatory properties, they may play an important role in human health. The purpose of this review was to synthesize the effects of natural honey on pro-and anti-inflammatory cytokines. The effects of honey on wound healing and immunity appear to be inconsistent. The available databases )PubMed and Scopus) were searched and 42 studies were assessed. In patients with cancer, honey has been reported to inhibit the effects of pro-inflammatory factors such as TNF-α and IL-6. In patients with neuro-inflammatory disorders honey has been shown to inhibit the expression of pro-inflammatory markers. It has also been reported that honey can reduce TNF-α expression in conditions associated with liver injury, by suppressing TNF-α converting enzyme activity. Honey inhibits APAP-induced hepatocellular necrosis by modulating the expression of IL-10 and IL-1ß. Animal studies have shown that honey can reduce serum IL-1ß, IL-6 and TNF-α concentration and increase IL-10 concentrations in a model of gastric ulcer. Some studies in diabetics have shown that honey can reduce serum TNF-α, IL-6, IL-1ß and TGF-ß by inhibiting NF-Kß. The source and type of honey and its component have not been indicated in various clinical and practical studies, which are a limitation of these studies, in relation to reproducing them. Sigma, Manuka, Gelam and Tulang honey have been used in most of the in vitro and animal studies. The animal studies have demonstrated similar effects on pro-inflammatory factors, which include reducing serum TNF-α, IL-6 and IL-1β as well as increasing IL-10. There are few human RCTs investigating the effects of honey on inflammatory cytokines. Only one RCT has reported the type of honey that they have used. Tulang honey has been reported to increase serum TNF-α and decrease hs-CRP, which is therefore controversial. Further high-quality studies are needed to firmly establish the clinical efficacy of honey. Because most studies had used different duration, type of honey and dosage, which make them difficult to contextualize, as the phytochemical content of a honey may depend on its source.

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Antibacterial properties and healing effects of Melipona scutellaris honey in MRSA-infected wounds of rats

Cited by 15 publications

References 22 publications

Stingless bee honey and its potential value: a systematic review

Stingless bee honey and its potential value: a systematic review

Bee Products and Essential Oils as Alternative Agents for Treatment of Infections Caused by S. aureus

The effects of honey on pro‐ and anti‐inflammatory cytokines: A narrative review

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