Whole-body vibration improves fracture healing and bone quality in rats with ovariectomy-induced osteoporosis

Butezloff, Mariana Maloste; Zamarioli, Ariane; Leoni, Graziela Bianchi; Sousa‐Neto, Manoel Damião; Volpon, José Batista

doi:10.1590/s0102-865020150110000002

Cited by 22 publications

(18 citation statements)

References 31 publications

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“…For the femoral fracture procedure, animals were anesthetized with a combination (1:1) of xylazine and ketamine (0.1 mg/100 g) injected intramuscularly, and the right pelvic limb was shaved. Next, the right thigh was restrained by two metallic supports [7]. The blunted blade of a guillotine apparatus was lowered onto the middle part of the thigh, and a vertical force was applied until an abrupt decrease in resistance occurred, indicating femur failure (fracture).…”

Section: Surgical Proceduresmentioning

confidence: 99%

“…The analysis was done using DXA with a Lunar DPX-IQ densitometer (Lunar Version 4.7e; GE Healthcare, Little Chalfont, UK) [7,17,19]. The entire fractured femur was scanned and the bone mineral density ([BMD] in g/cm 2 ), bone mineral content ([BMC] in g), and area (in cm 2 ) were assessed over the full extent of the callus.…”

Section: Assessment Of Bone Mineral Density Bone Mineral Content Anmentioning

confidence: 99%

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Exposure to Secondhand Smoke Impairs Fracture Healing in Rats

Santiago

Zamarioli

Sousa‐Neto

et al. 2017

Clinical Orthopaedics &Amp; Related Research

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Section: Surgical Proceduresmentioning

confidence: 99%

Section: Assessment Of Bone Mineral Density Bone Mineral Content Anmentioning

confidence: 99%

Exposure to Secondhand Smoke Impairs Fracture Healing in Rats

Santiago

Zamarioli

Sousa‐Neto

et al. 2017

Clinical Orthopaedics &Amp; Related Research

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“…Vibration has been demonstrated to have beneficial effects in the therapeutic field, such as in the increase in bone mass with 4 weeks of application 22 . However, it was observed that this stimulus could be harmful with an increase in exposure time by 8 weeks 15 .…”

Section: Discussionmentioning

confidence: 99%

“…One of the resources employed in the treatment of postmenopausal osteoporosis is vibration applied by a vibrating platform 7 , which can achieve anabolic responses following daily application for 5 to 20 minutes, 2 to 5 times a week 7,22 . Despite that stimulus being invoked as a form of treatment, exposure to vibration may cause tissue damage 8 .…”

Section: Introductionmentioning

confidence: 99%

Morphological and nociceptive effects of mechanical vibration on the sciatic nerve of oophorectomized Wistar rats

Kakihata

Peretti

Wutzke

et al. 2019

Motriz: rev. educ. fis.

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Aim: To evaluate the effects of whole-body vibration in the sciatic nerve of oophorectomized Wistar rats, on nociceptive and morphological parameters, such as fiber, axon, and myelin sheath diameters, G ratio, number of nerve fiber and nuclei of Schwann cells, and percentage of connective tissue. Method: Sixty-four rats were used in the groups sham-operate and oophorectomy (n = 32/group); after surgical procedures, each group was subdivided into four: euthanized in the 12 th week, untreated and treated for four weeks; and euthanized in the 16 th week, untreated and treated for eight weeks. The treatment with vibration was performed with a 60 Hz frequencies, for 10 minutes, three days a week, with duration of 4 or 8 weeks. Nociception was evaluated later, in the right paw, by means of a digital analgesimeter, prior to surgery, at the beginning and at the end of the protocol. After the trial period, the sciatic nerve was dissected for examination of the general morphology of the tissue and morphometric analysis; later, the animals were euthanized. Results: Regarding nociception and the morphometry of the sciatic nerve, independent of oophorectomy and treatment time, there was no statistically significant difference within and between groups. Also, the general morphology of the tissue in all groups had characteristics that were preserved. Conclusion: The mechanical vibration did not alter the nociceptive threshold and the morphological aspects of nerve fibers in oophorectomized Wistar rats.

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“…For this purpose, the rats were placed on a vibratory table in a custom-designed cage measuring 20 × 25 × 10 cm. This acrylic cage had two chambers, allowing the treatment of two rats at a time while they were physically separated from each other [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

Histological and Radiological Evaluation of Low-Intensity Pulsed Ultrasound Versus Whole Body Vibration on Healing of Mandibular Bone Defects in Rats

Hsieh

Mohammadi

et al. 2020

Medicina

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Background and Objectives: Mechanical stimulation can improve the structural properties of the fracture site and induce the differentiation of different cell types for bone regeneration. This study aimed to compare the effect of low-intensity pulsed ultrasound stimulation (LIPUS) versus whole body vibration (WBV) on healing of mandibular bone defects. Materials and Methods: A mandibular defect was created in 66 rats. The rats were randomly divided into two groups of rats. Each group was subdivided randomly by three groups (n = 11) as follows: (I) control group, (II) treatment with LIPUS, and (III) treatment with WBV. The radiographic changes in bone density, the ratio of lamellar bone to the entire bone volume, the ratio of the newly formed bone to the connective tissue and inflammation grade were evaluated after 1 and 2 months. Results: LIPUS significantly increased the radiographic bone density change compared to the control group at the first and second month postoperatively (p < 0.01). WBV only significantly increased the bone density compared to the control group at the second month after the surgery (p < 0.01). Conclusions: Application of LIPUS and WBV may enhance the regeneration of mandibular bone defects in rats. Although LIPUS and WBV are effective in mandibular bone healing, the effects of LIPUS are faster and greater than WBV.

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Whole-body vibration improves fracture healing and bone quality in rats with ovariectomy-induced osteoporosis

Abstract: Vibration therapy improved bone quality and the quality of the fracture bone callus in ovariectomized rats.

Cited by 22 publications

References 31 publications

Exposure to Secondhand Smoke Impairs Fracture Healing in Rats

Exposure to Secondhand Smoke Impairs Fracture Healing in Rats

Morphological and nociceptive effects of mechanical vibration on the sciatic nerve of oophorectomized Wistar rats

Histological and Radiological Evaluation of Low-Intensity Pulsed Ultrasound Versus Whole Body Vibration on Healing of Mandibular Bone Defects in Rats

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