Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition

Abstract

PURPOSE:To evaluate the heart and the Tc-99m-sestamibi biodistribution after statin pretreatment in a rat model of abdominal sepsis. METHODS:Twenty-four Wistar rats were randomly distributed into four groups (n=6 per group): 1) sepsis with simvastatin treatment, 2) sepsis with vehicle, 3) sham control with simvastatin and 4) sham control with vehicle. 24 hours after cecal ligation and puncture rats received 1.0MBq of Tc-99m-sestamibi i.v. 30min after, animals were euthanized for ex-vivo tissue counting and myocardium histological analysis. RESULTS:Myocardial histologic alterations were not detected 24 hours post-sepsis. There was significantly increased cardiac Tc-99m-sestamibi activity in the sepsis group with simvastatin treatment (1.9±0.3%ID/g, p<0.001) in comparison to the sepsis group+vehicle (1.0±0.2%ID/g), control sham group+ simvastatin (1.2±0.3%ID/g) and control sham group (1.3±0.2%ID/g). Significant Tc-99m-sestamibi activity in liver, kidney and lungs was also detected in the sepsis group treated with simvastatinin comparison to the other groups. CONCLUSIONS:Statin treatment altered the biodistribution of Tc-99m-sestamibi with increased cardiac and solid organ activity in rats with abdominal sepsis, while no impact on controls. Increased myocardial tracer activity may be a result of a possible protection effect due to increased tissue perfusion mediated by statins.Key words: Simvastatin. Sepsis. Inflammation. Heart. Technetium Tc 99m Sestamibi. Rats.Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc 99m -sestamibi biodistribition Acta

Effects of statins on the development of sepsis and organ dysfunction in hospitalized older patients in China

“… 28 , 29 , 30 , 31 , 32 Statin treatment also altered biodistribution of Tc-99m-sestamibi in rats with abdominal sepsis, interpreted as a protective effect because of statin-mediated increased tissue perfusion. 33 The protective effect of statins is attributed to their effects on insulin sensitivity, improving insulin signaling in peripheral tissues, 28 preserving cardiac function and hemodynamic status, 29 , 31 reversing inflammatory cytokines levels, 15 , 16 , 17 and enhancing bacterial clearance. 17 Additionally, statins appear to decrease nitric oxide production and restore impaired vascular responsiveness in sepsis.…”

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