Deleterious effects of prepubertal corticosterone treatment on rat prostate

Pinto, Flávia Cristina Morone; Silva, Dı́lson; Silva, Pamella Campos; Pereira, Luiza Morone; Morone, Arlene Regina; Costa, Waldemar S.; Cortez, Célia Martins; Sampaio, Francisco J.B.

doi:10.1590/s0102-865020150060000002

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Normally, these hormones help in the general body growth and formation and maturation of organs, functioning together with GH (growth hormone), thyroid hormones, adrenal androgens and sexual hormones [52] [53]. However, GC excess can exert negative effects on body growth, inhibiting spontaneous secretion of the cited hormones and influencing negatively on cell proliferation [10] [54]- [59].…”

Section: Definitions Of Stress In Living Systemsmentioning

confidence: 99%

Biological Stress as a Principle of Nature: A Review of Literature

Cortez¹,

Silva²

2020

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This review paper attempts to approximate the concept of biological stress to the stress concept in Physics using the phenomenological view of physics to discuss the source of generator forces of biological stress state. Based on the literature, parallels are drawn between the two concepts and a discussion on the steady state in open systems and homeostatic state in biological systems is developed. Using the concepts of thermodynamic entropy and informational entropy, and comparing stress in living systems and nonliving, we attempt to build a basis for a view of stress as a principle of nature linked to the adaptability property of matter, opposing entropy. It is known that the increasing number of microstates possible in a complex system increases the entropy. In that way, entropy is related to the amount of additional information needed to specify the exact physical state of a system, given its macroscopic specification. By controlling the metabolic processes (catabolism-anabolism) to decrease the entropy, stress reduces the number of possible states for which the living system could evolve, avoiding the loss of "life information", preserving its characteristics and preventing its extinction. The loss of function of a species within an ecosystem or of cells within an organ can be showing that the limits of the stress principle were "transgressed". That is, the intensity and/or duration of stress exceeded the capacity of living organism to process of information extracted from stressor and reprogram its physiological mechanisms, activating its adaptability process, while its internal balance is preserved.

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Section: Definitions Of Stress In Living Systemsmentioning

confidence: 99%

Biological Stress as a Principle of Nature: A Review of Literature

Cortez¹,

Silva²

2020

OJBIPHY

View full text Add to dashboard Cite

show abstract

The Growth of Healthy and Cancerous Tissues

Szigeti¹,

Szász²,

Szász³

2020

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The structure of the tissues is formed in a self-similar manner, forming fractal structures in their transport networks. The structure exhibits allometric forming and so-called scaling behavior. This is a basic growth model fine-tuned by various connections of the cells (junctions and adherent connections), intended to direct material and energy transports between them. This secondary control of cell metabolism decreases primary metabolic transport through the free surfaces of the cells. The cellular network is formed by triggering the endogenous electric fields, which are dominantly governed by cell membrane potential. Proliferation exhibits a different electric pattern due to the low cell-membrane potential and resulting negativity relative to its environment. This potential change characterizes cells in normal proliferation and a cluster of cells (a tumor) in the case of cancerous development. This latter has certain similarities to the leakage transport of liquid in porous media, substituting the pressure with endogenous tumor potential. The average survival of a tumor depends on the kind of available metabolic transport and the fractal dimensions of the newly built angiogenic network.

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Deleterious effects of prepubertal corticosterone treatment on rat prostate

Cited by 2 publications

References 23 publications

Biological Stress as a Principle of Nature: A Review of Literature

Biological Stress as a Principle of Nature: A Review of Literature

The Growth of Healthy and Cancerous Tissues

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