Effect of cyclosporine on liver regeneration in partial hepatectomized rats

Abstract

PURPOSE:To evaluate the influence of the cyclosporine in liver regeneration in rats submitted to an experimental model of 70% hepatectomy. METHODS:Forty male rats were randomly divided in four subgroups (C.24h, C.7d, E.24h, E.7d), according to the drug used and the day of sacrifice (24 hours and 7 days). Cyclosporine (10mg/Kg/day) was given to the study subgroup and 1 ml of 0.9% sodium chloride was to the control subgroup. Resection of left lateral lobe and median lobe performing 70% of liver mass. During the animals' death, KWON formula was applied. Counting of mitotic figures and percentage of positive nucleus with PCNA and Ki-67 were evaluated. RESULTS:In the 2 nd , 4 th PO and death days, E.7d lose more weight than C.7d. Regarding to the KWON formula, the C.7d regenerated more than the C.24h and the same with the E.7d. Comparing between the groups, only E7d subgroup was statistically significant compared with C.7d, showing the stimulating effect of cyclosporine in liver regeneration. Immunohistochemestry had significant results between the study subgroups. The mitotic index revealed statistical differences in the control subgroups. CONCLUSION:Cyclosporine, in spite of being an immunosuppressive drug, has a positive effect in liver regeneration, although reduce the animal's body weight.

Aminodihydrophthalazinedione Sodium Transdermal Therapeutic System Specific Activity on an ExperimentalModel of Extensive Liver Resection

“…The scientific literature describes studies of the positive effect of various immunosuppressants on liver regeneration. In particular, Giorgio Alfredo Pedroso Baretta et al describe the positive effect of cyclosporine on liver regeneration in rats undergoing 70% hepatectomy in an experimental model [ 19 ]. The positive effect of tacrolimus-based immunosuppressive therapy in adult Wistar rats on a similar experimental model is also described.…”

The comparative analysis of the effectiveness of stimulation of liver regeneration by bone marrow cells and total RNA of these cells

“…Для предотвращения пострезекционной ОПН в раннем послеоперационном периоде разработаны новые хирургические приемы щадящего выполнения этих операций [7][8][9]. Была также предложена тактика расширенного применения экстракорпоральных систем детоксикации организма [10] и медикаментозных препаратов, способных повысить в сохранившихся клетках печени митотическую и пролиферативную активность, требуемую для восстановления исходных размеров этого органа [11][12][13][14][15][16].…”

Μελέτη της επιδράσεως του αντιαγγειογενετικού παράγοντα sorafenib στην ηπατική αναγέννηση

“…ε απηέο αλαθέξεηαη φηη νη κεηαβνιέο κεηαμχ πξψηνπ θαη ηξίηνπ κήλα είλαη κηθξέο θαη νδεγνχλ ζην ζπκπέξαζκα πσο ε επαηηθή αλαγέλλεζε νινθιεξψλεηαη σο επί ην πιείζηνλ θαηά ηνλ πξψην κήλα.Τπάξρνπλ θαη άιινη εξεπλεηέο πνπ ππνζηεξίδνπλ φηη ε επαηηθή αλαγέλλεζε νινθιεξψλεηαη ηελ πξψηε εβδνκάδα κεηά ηελ επέκβαζε(28,67,383,384). ε κειέηεο πνπ σο παξάκεηξνο εθηίκεζεο ηεο επαηηθήο αλαγέλλεζεο ρξεζηκνπνηείηαη ν αλαγελλεηηθφο δέηθηεο παξαηεξείηαη ζηαδηαθή αχμεζή ηνπ θαηά ηηο πξψηεο εκέξεο κεηά ηελ επαηεθηνκή, μεθηλψληαο απφ ηηο πξψηεο 24 ψξεο θαη θηάλνληαο ζε κέγηζηε ηηκή (83,6±11,46) ζηηο 168 ψξεο κεηά ηε κεξηθή επαηεθηνκή(367,385). Σα επξήκαηα ηεο παξνχζαο κειέηεο ζπκθσλνχλ κε ηα παξαπάλσ, θαζψο ν κέζνο φξνο ηνπ αλαγελλεηηθνχ δείθηε ζηελ νκάδα ειέγρνπ (Οκάδα 1) ήηαλ67,25±2,024 ζηηο 48ψξεο, 80,88±1,39 ζηηο 96 ψξεο θαη 88,88±1,62 ζηηο 168 ψξεο κεηά ηελ επέκβαζε.…”