Attenuation of copaiba oil in hepatic damage in rats

Brito, Marcus Vinicius Henriques; Costa, Felipe D’Almeida; Vasconcelos, Diego Matos de; Costa, Lauro Augusto Veloso; Yasojima, Edson Yuzur; Teixeira, Renan Kleber Costa; Yamaki, Vítor Nagai

doi:10.1590/s0102-86502014001900002

Cited by 6 publications

(5 citation statements)

References 16 publications

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“…11,12 Because of the benefits of applying copaiba oil as a topical use based on empirical evidence in the past, it is probable that the scientific community was influenced in researching the use of copaiba oil in the form most used by local Amazonian people, who used copaiba oil on the skin. According to Brito et al, 13 the practice of using medicinal plants is common in developing countries. The Amazon is a nursery of medicinal plants, and many studies have been made with copaiba oil as an alternative for aiding in inflammatory processes, such as healing skin ulcers and infections, with very satisfactory results in the form of topical use.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

et al. 2018

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Recent studies demonstrated that one of the major components of the copaiba oil, β-caryophyllene, has an anti-inflammatory effect. 4 Copaiba oil is extracted from the copaifera, a Abstract Many medicinal plants are sought as alternative therapies for various conditions, as opposed to synthetic alternatives. The Brazilian Amazon provides a plethora of plants with various therapeutic and medicinal properties. One of them is copaiba oil, a natural product of the biodiversity of the Amazon. The anti-inflammatory and antimicrobial properties of copaiba oil have been drawing the attention of the scientific community as a great alternative in the treatment of illnesses associated with inflammatory and infectious processes. The purpose of the present study is to evaluate and analyze the latest publications on the use of copaiba oil in the PubMed/Medline database from 2014 to 2017. Forty-two articles were collected, verifying anti-inflammatory activity, antimicrobial activity, healing, and antitumor activity. The results found on researches with copaiba oil according to publication dates were 11.9% in 2014, 38.1% in 2015, 16.7% in 2016, and 33.3% in 2017. In the analyzed studies, the proposed administration of copaiba oil was 50% topical, 28.6% oral, 9.5% enteral, 4.8% subcutaneous, and 7.1% others. In the objectives of the presente study in relation to the administration of copaiba oil, the result was 31% antimicrobial, 28.6% anti-inflammatory, 9.5% antitumor, 9.5% healing, and 21% others. Regarding the types of research, we have found 50% in vitro, 40.4% in vivo animals, 2.4% in vivo human, 2.4% review and 4.8% others. Regarding the significance factor evaluation, the result was 100% positive in antitumor activity, 84% positive in infection and inflammation pathology, 62% positive in others, like dental processes, food technology application support and as a drug absorption vehicle, and 50% in healing. The results presented in the current meta-analysis show that copaiba oil is an effective alternative to treatments of illnesses such as chronic inflammation, infectious diseases, various types of cancer, autoimmune diseases, and as a vehicle for the absorption of other drugs. Thus, more studies regarding the benefits of copaiba oil could provide a great contribution to the medical community in the treatment of the aforementioned illnesses.

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Section: Resultsmentioning

confidence: 99%

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

et al. 2018

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“…The pharmacological data regarding this specific use are very scarce, but some investigations have been conducted with the 'copaiba' oleoresin, also popularly ingested due to its alleged beneficial health effects. [179] Brito et al [88] evaluated the oral effect of the oil on the attenuation of liver damage as a prophylactic (at doses of 0.63 or 3.8 mL/kg administered for 7 days before acetaminophen) and as a therapeutic (at a dose of 3.8 mL/kg administered 2 h after acetaminophen) in rats. Both treatments offered hepatoprotection in the rodents, compared to positive (N-acetylcysteine) and negative controls, reducing the levels of hepatic serum enzymes.…”

Section: Copaifera Langsdorffii Desfmentioning

confidence: 99%

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

Arbo

Konrath

2022

Chemistry & Biodiversity

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The native flora of Brazil covers a large biodiversity of plants, some of which have important pharmacological properties. Ethnobotanical studies have established that the folk use of plants for hepatobiliary disorders is very common in Brazil. This review aimed to compile, describe and discuss the main native Brazilian medicinal plants used as hepatoprotective agents listed on 25 books by authors from various regions in the country. Based on the 153 species found, a comprehensive analysis of the most relevant scientific studies is presented, including Piper umbellatum, Echinodorus macrophyllus, Fevillea trilobata and Achyrocline satureioides. Some medicinal plants share both a large number of citations and scientific evidence to corroborate their hepatoprotective effects, including Solanum paniculatum, Baccharis crispa and Phyllanthus niruri, which could be of interest to develop new phytomedicines. Additionally, some active ingredients are indicated as being responsible for the liver protective effects described, particularly phenolic compounds (flavonoids, coumestans and lignans).

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“…2 Copaiba oil is known for its antioxidant, antitumor, anti-inflammatory, and even bacteriostatic effects. [3][4][5] Copaiba oil has an unctuous character, so nanoemulsions of this oil could improve patient acceptability by converting it into a more pleasant hydrophilic formulation, in addition to improving the bioavailability of its active antioxidant molecules. Through nanoemulsions, it is possible to improve the chemical stability of substances, prolong the duration of activity, and delineate the site of action.…”

Section: Introductionmentioning

confidence: 99%

“…Copaiba oil has been used to treat stomach ulcers, as well as skin, hepatic, and intestinal disorders. 3,9,10 However, this alternative medicine has not been investigated yet in cardiovascular diseases, such as pulmonary arterial hypertension (PAH).…”

Section: Introductionmentioning

confidence: 99%

Effect of Free and Nanoencapsulated Copaiba Oil on Monocrotaline-induced Pulmonary Arterial Hypertension

Carraro

Castro²,

Tavares³

et al. 2017

Journal of Cardiovascular Pharmacology

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Copaiba oil comes from an Amazonian tree and has been used as an alternative medicine in Brazil. However, it has not been investigated yet in the treatment of cardiovascular diseases. This study was designed to test whether copaiba oil or nanocapsules containing this oil could modulate monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). Male Wistar rats (170 ± 20 g) received oil or nanocapsules containing this oil (400 mg/kg) by gavage daily for 1 week. At the end of this period, a single injection of MCT (60 mg/kg i.p.) was administered and measurements were performed after 3 weeks. The animals were divided into 6 groups: control, copaiba oil, nanocapsules with copaiba oil, MCT, oil + MCT, and nanocapsules + MCT. Afterward, echocardiographic assessments were performed, and rats were killed to collect hearts for morphometry and oxidative stress. MCT promoted a significant increase in pulmonary vascular resistance, right ventricle (RV) hypertrophy, and RV oxidative stress. Both oil and copaiba nanocapsules significantly reduced RV hypertrophy and oxidative stress. Pulmonary vascular resistance was reduced by copaiba oil in natura but not by nanocapsules. In conclusion, copaiba oil seems to offer protection against MCT-induced PAH. Our preliminary results suggest that copaiba oil may be an important adjuvant treatment for PAH.

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Attenuation of copaiba oil in hepatic damage in rats

Abstract: PURPOSE:To investigate the copaiba oil on the hepatic damage induced by acetaminophen, comparing against corn oil.

Cited by 6 publications

References 16 publications

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

Effect of Free and Nanoencapsulated Copaiba Oil on Monocrotaline-induced Pulmonary Arterial Hypertension

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