Effects of prepubertal corticosterone treatment on urinary bladder

Abstract

PURPOSE:The aim of this work was to analyze the bladder wall modifications after a chronic treatment with high doses of corticosterone in prepubertal rats. METHODS:This study included 26 male rats assigned into four groups: T30 was treated with corticosterone until 29 days of age and killed at day 30, while T65 group received the same treatment but was killed at day 65. Each group had its own control group (C30 and C65). For treated animals, daily intraperitoneal injections of corticosterone (20 mg/Kg) were administered between 7 th and 29 th day of life. Bladders were removed and collagen, smooth muscle, elastic fibers system, vascular density and epithelium were analyzed by morphometrical methods, immunofluorescence, and biochemistry. RESULTS:Vascular density in lamina propria was reduced by 40% (p<0.05) in group T65. Collagen organization was altered in T30and T65, although total collagen concentration was unchanged. The T65 group had an increase in elastic system fibers. There was no difference in epithelial height and cell density between the groups. Concerning the smooth muscle fibers density we observed a 19% increase (p<0.05) in the T65 group.CONCLUSION: Prepubertal administration of corticosterone induces structural modifications in the bladder of rats in a medium term analysis.

Nontraumatic bladder rupture: The images before and after

“…Pathological bladder‐wall fragility and increased intrabladder pressure are recognized as risk factors for nontraumatic bladder rupture. In our case, sequential CT images suggested that distended bladder caused by acute cystitis provoked bladder rupture on the background of bladder‐wall fragility due to long‐term steroid use 1 and/or diverticulum 2 …”

Spontaneous bladder rupture: the images before and after

“…Pathological bladder wall fragility and increased intra-bladder pressure are recognized as risk factors for nontraumatic bladder rupture. In our case, sequential CT images suggested excessive bladder retention caused by acute cystitis provoked bladder rupture on the background of bladder-wall fragility due to longterm steroid use [1] and/or diverticulum. [2]…”