Neovascularization after surgical exposure of rat external jugular vein endothelium

Nascimento, José Francimário Bezerra do; Pitta, Guilherme Brandão Benjamin; Miranda, Fausto

doi:10.1590/s0102-86502013001200003

Cited by 1 publication

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“…Finally, the head and neck structures remained in their normal anatomical position, throughout the experimental study itself. For otorhinolaryngology researchers in the future, the information from this study will allow better animal selection and surgical planning from what was possible in the past (16,17).…”

Section: Discussionmentioning

confidence: 99%

Comparing the Organs and Vasculature of the Head and Neck in Five Murine Species

Kim

Chao

et al. 2018

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Abstract. Background The murine species are often used as an in vivo model due to their relatively short developmental period and comparatively cheap price. To evaluate the pathologic mechanism or effect of a new treatment or medication, a large sized mammalian is the optimal. However, there are major limitations for their use in experimental studies. As a result, a murine animal is often chosen instead. But, in these smaller animals, there are challenges, including the relatively small size of the head and neck structures, challenges in identifying the vascular and neural anatomy and the unavailability of a surgical atlas of normal anatomy.Previous studies suffered from two major problems. First, dissection produced trauma to the microvascular system, resulting in staining of the entire dissection field. This problem was aggravated whenever major vessels had to be removed. Second, attempts to avoid this problem, by first using formaldehyde to fix the tissues, made delicate 861

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Section: Discussionmentioning

confidence: 99%

Comparing the Organs and Vasculature of the Head and Neck in Five Murine Species

Kim

Chao

et al. 2018

View full text Add to dashboard Cite

show abstract

Neovascularization after surgical exposure of rat external jugular vein endothelium

Cited by 1 publication

References 11 publications

Comparing the Organs and Vasculature of the Head and Neck in Five Murine Species

Comparing the Organs and Vasculature of the Head and Neck in Five Murine Species

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