Influence of the peritoneal lavage with bupivacaine on the survival and resistance of colonic anastomoses performed under fecal peritonitis in rats

Camargo, Michel Gardere; Fagundes, João José; Leal, Raquel Franco; Ayrizono, Maria de Lourdes Setsuko; Rossi, Débora Helena dos Gonçalves; Oliveira, Priscilla de Sene Portel; Chung, Wu Feng; Lee, Huei; Coy, Cláudio Saddy Rodrigues

doi:10.1590/s0102-86502013001100007

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…[30][31][32] To the authors' knowledge, pharmacokinetic studies after IP administration of bupivacaine to dogs have not been reported. However, the dose of bupivacaine (2 mg/ kg) used in the present study resulted in serious nonfatal acute toxic effects after IV infusion to conscious sheep 33 and corresponded with a peak arterial blood concentration of 8 µg/mL.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

Benito¹,

Monteiro²,

Beaudry³

et al. 2016

ajvr

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OBJECTIVE To evaluate pharmacokinetics of bupivacaine after IP administration to cats undergoing ovariohysterectomy. ANIMALS 8 healthy cats. PROCEDURES Anesthesia was induced with propofol and maintained with isoflurane. Buprenorphine (0.02 mg/kg, IV) and meloxicam (0.2 mg/kg, SC) were administered. A 20-gauge catheter was inserted into a jugular vein for blood sample collection. A ventral midline incision was made, and a solution of 0.5% bupivacaine (2 mg/kg) diluted with an equal volume of saline (0.9% NaCl) solution (final concentration, 0.25% bupivacaine) was injected into the peritoneal space over the right and left ovarian pedicles and caudal aspect of the uterus before ovariohysterectomy. Cats were monitored for signs of bupivacaine toxicosis. Venous blood samples (2 mL) were collected before (time 0) and 2, 5, 10, 15, 20, 30, 60, 120, and 240 minutes after bupivacaine administration. Plasma bupivacaine concentrations were determined with a liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters were determined by data plotting followed by analysis with a noncompartmental model. RESULTS No signs of bupivacaine toxicosis were observed. Maximum bupivacaine plasma concentration was 1,030 ± 497.5 ng/mL at a mean ± SD value of 30 ± 24 minutes after administration. Mean elimination half-life was 4.79 ± 2.7 hours. Mean clearance indexed by bioavailability and volume of distribution indexed by bioavailability were 0.35 ± 0.18 L•h/kg and 2.10 ± 0.84 L/kg, respectively. CONCLUSIONS AND CLINICAL RELEVANCE Intraperitoneal administration of bupivacaine resulted in concentrations that did not cause observable toxicosis. Studies to investigate analgesic effects for this technique in cats are warranted.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

Benito¹,

Monteiro²,

Beaudry³

et al. 2016

ajvr

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“…In the study groups, mortality was lower than in controls (drainage alone, not washed or washed with saline) (51,52).…”

Section: Anti-inflammatory Antimicrobial and Immunomodulatory Effectmentioning

confidence: 75%

Neuraxial Regional Anaesthesia in Patients with Active Infection and Sepsis: A Clinical Narrative Review

Gimeno

Errando

2018

Turk J Anaesth Reanim

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“…During the last decade of the twentieth century (and in some more recent literature [25][26][27][28][29][30][31][32]) animal and other experimental studies began addressing the question of which fluid and how much [8,[25][26][27][33][34][35][36][37][38][39][40]. It was during this period that the potential adverse effects of the use of abdominal washouts were described: upregulation of pro-inflammatory mediators, damage to peritoneal mesothelial cells and polymorphonuclear neutrophil membranes, promotion of postoperative adhesions, documented instances of bacterial translocation, failure to effectively decrease peritoneal bacterial counts, and potential adverse effects on final hemostasis (through technical or chemical issues) [7,33].…”

Section: Discussionmentioning

confidence: 99%

A Randomized Controlled Trial on Intra-Abdominal Irrigation during Emergency Trauma Laparotomy; Time for Yet Another Paradigm Shift

Mashbari

Hemdi

Chow

et al. 2018

BEAT

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Objective: To determine the optimal volume of abdominal irrigation that will prevent surgical site infections (both deep and superficial), eviscerations and fistula formations; and improve 30-day mortality in trauma patients. Methods:We conducted a three-arm parallel clinical superiority randomized controlled trial comparing different volumes of effluent (5, 10 and 20 liters) used in trauma patients (both blunt and penetrating) age 14 and above undergoing an emergency laparotomy between April 2002 and July 2004 in a busy urban Level 1 trauma center. Results: After randomization, a total of 204 patients were analyzed. All patient groups were comparable with respect to age, gender distribution, admission injury severity score, and mechanism of injury, estimated blood loss and degree of contamination. The mortality rate overall was 1.96% (4/204).No differences were noted with respect to contamination, wound infection, fistula formation, and evisceration. The twenty liter group (Group III) showed a trend toward an increased incidence of deep surgical site infections when compared to the five liter (Group I) (p=0.051) and ten liter (Group II) (p=0.057) groups. This did not however reach statistical significance. Conclusion: The old surgical adage "the solution to pollution is dilution" is not applicable to trauma patients. Our results suggest that using more irrigation, even when large amounts of contamination have occurred, does not reduce post-operative complications or affect mortality; and it may predispose patients to increased incidence of abscess formation. (Trial registration number: ISRCTN66454589)

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Influence of the peritoneal lavage with bupivacaine on the survival and resistance of colonic anastomoses performed under fecal peritonitis in rats

Cited by 6 publications

References 15 publications

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

Neuraxial Regional Anaesthesia in Patients with Active Infection and Sepsis: A Clinical Narrative Review

A Randomized Controlled Trial on Intra-Abdominal Irrigation during Emergency Trauma Laparotomy; Time for Yet Another Paradigm Shift

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