Outcome of superficial squamous cell carcinoma of the esophagus: a clinicopathological study

Henry, Maria Aparecida Coelho de Arruda; Lerco, Mauro Masson; Naresse, Luiz Eduardo; Crema, Eduardo; Rodrigues, Maria Aparecida Marchesan

doi:10.1590/s0102-86502013000500009

Cited by 4 publications

(7 citation statements)

References 22 publications

(32 reference statements)

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“…7 Well-known carcinogens for the development of both ESCC and MPTs, especially in the head and neck region and lungs, are tobacco and alcohol. 8,9 In retrospective studies, up to 19.3% of patients with primary ESCC develop MPTs in the UADT. 3,[10][11][12][13] Most studies consider the head and neck region, lungs and oesophagus as the UADT, the stomach is another important region to be at risk for MPT development.…”

Section: Introductionmentioning

confidence: 99%

Increased risk of second primary tumours in patients with oesophageal squamous cell carcinoma: a nationwide study in a Western population

et al. 2021

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Background Patients with primary oesophageal squamous cell carcinoma are at risk of developing multiple primary tumours in the upper aero digestive tract. To date, most studies are performed in the Asian population. We aimed to evaluate the risk of multiple primary tumours in the upper aero digestive tract and stomach in patients with oesophageal squamous cell carcinoma in a Western population. Methods We performed a nationwide, retrospective cohort study in collaboration with the Netherlands Cancer Registry. Patients with primary oesophageal squamous cell carcinoma, diagnosed between 2000–2016, were included. Primary endpoints were synchronous and metachronous multiple primary tumour risk. Results The cohort consisted of 9058 patients, diagnosed with oesophageal squamous cell carcinoma (male: 57.3%, median age 67 years). In 476 patients (5.3%), 545 multiple primary tumours have been diagnosed. Most of them were located in the head and neck region (49.5%). Among all multiple primary tumours, 329 (60.4%) were diagnosed synchronously (<6 months after oesophageal squamous cell carcinoma diagnosis) and 216 (39.6%) metachronously (≥6 months). Patients with oesophageal squamous cell carcinoma had a significantly increased risk of both synchronous (standardised incidence ratio 10.95, 99% confidence interval 9.40–12.53) and metachronous multiple primary tumours (standardised incidence ratio 4.36, 99% confidence interval 3.56–5.10), compared to the general population. The median interval to metachronous second primary tumour diagnosis was 3.0 years (interquartile range 1.8–5.9). Conclusion Approximately one in 20 patients with primary oesophageal squamous cell carcinoma have a second primary tumour in the upper aero digestive tract or stomach, either at the time of oesophageal squamous cell carcinoma diagnosis or at a later stage. As second primary tumours occur at an increased risk compared to the general population, prospective studies are necessary to investigate the yield and survival benefit of screening for second primary tumours in patients with oesophageal squamous cell carcinoma.

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Section: Introductionmentioning

confidence: 99%

Increased risk of second primary tumours in patients with oesophageal squamous cell carcinoma: a nationwide study in a Western population

et al. 2021

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“…6 An important risk factor in Western countries for the development both of ESCC and SPTs is alcohol. 7,8 Head and neck second primary tumors (HNSPTs) in patients with primary ESCC are reported to be up to 7% in retrospective studies. 4,5 The prognosis and survival of patients with esophageal cancer (EC) is poor because most ECs are diagnosed in advanced stages, when definitive cure is most often not achievable.…”

Section: Introductionmentioning

confidence: 99%

“…The presence of SPTs can be explained by the “field cancerization” theory: Premalignant epithelial changes can occur because of chronic local exposure to common carcinogens, such as alcohol and tobacco, which contributes to the development of syn‐ and metachronous SPTs 6 . An important risk factor in Western countries for the development both of ESCC and SPTs is alcohol 7 , 8 …”

Section: Introductionmentioning

confidence: 99%

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Screening for head and neck second primary tumors in patients with esophageal squamous cell cancer: A systematic review and meta‐analysis

et al. 2019

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Background Esophageal squamous cell carcinomas (ESCCs) are often accompanied by head and neck second primary tumors (HNSPTs). The prognosis of patients with an additional HNSPT is worse compared with patients with only ESCC. Therefore, early detection of HNSPTs may improve the overall outcome of patients with ESCC. The purpose of this study was to investigate the yield of endoscopic screening for HNSPTs in patients with primary ESCC. Methods We conducted a systematic literature search of all available databases. Studies were included if ESCC patients were endoscopically screened for HNSPT. The primary outcome was the pooled prevalence of HNSPTs. Results Twelve studies, all performed in Japan, were included in this systematic review with a total of 6483 patients. The pooled prevalence of HNSPTs was 6.7% (95% confidence interval: 4.9–8.4). The overall heterogeneity was high across the studies ( I2 = 89.0%, p < 0.001). Most HNSPTs were low stage (85.3%) and located in the hypopharynx (60.3%). The proportion of synchronous (48.2%) and metachronous (51.8%) HNSPTs was comparable. Conclusion Based on our results, HNSPT screening could be considered in patients with primary ESCC. All studies were performed in Japan; it is therefore not clear whether this consideration applies to the Western world.

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“…6,7 Interestingly, in the southeast region of Brazil, the high prevalence of megaesophagus and achalasia due to Chagas disease has been also described as another predisposition factor for ESCC development. [8][9][10] Achalasia is an esophageal motility disorder characterized by aperistalsis of the esophageal body and failure of lower esophageal sphincter relaxation, which lead to esophageal dilatation or megaesophagus and progressive dysphagia in affected patients. 11 The pathogenesis of achalasia is poorly understood and Chagas disease is the only proven etiological factor for achalasia.…”

Section: Introductionmentioning

confidence: 99%

Mutational profile of TP53 in esophageal squamous cell carcinoma associated with chagasic megaesophagus

Lacerda¹,

Cruvinel-Carloni²,

Oliveira³

et al. 2017

Diseases of the Esophagus

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Chaga's disease is an important communicable neglected disease that is gaining wider attention due to its increasing incidence worldwide. Achalasia due to chagasic megaesophagus (CM), a complication of this disease, is a known-yet, poorly understood-etiological factor for esophageal squamous cell carcinoma (ESCC) development. In this study, we aimed to perform the analysis of TP53 mutations in a series of Brazilian patients with ESCC that developed in the context CM (ESCC/CM), and to compare with the TP53 mutation profile of patients with benign CM and patients with nonchagasic ESCC. Additionally, we intended to correlate the TP53 mutation results with patient's clinical pathological features. By polymerase chain reaction (PCR) followed by direct sequencing of the hotspot regions of TP53 (exon 5 to 8), we found that TP53 mutations were present in 40.6% (13/32) of the ESCC/CM group, 45% (18/40) of the nonchagasic ESCC group, and in only 3% (1/33) of the benign CM group. Missense mutations were the most common in the three groups, yet, the type and mutated exon mutation varied significantly among the groups. Clinically, the groups exhibited distinct features, with both cancer groups (ESCC and ESCC/CM) been significantly associated higher consumption of alcohol and tobacco, older age, worse Karnofsky performance status, poor outcome than the patients with benign CM. No significant association was found between TP53 mutation profile and clinical-pathological features in any of the three groups. We describe first the time the analysis of TP53 mutations in ESCC that developed in the context of CM, and the observed high frequency of mutations, suggest that TP53 also plays an important role in the tumorigenic process of this unexplored etiological condition.

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Outcome of superficial squamous cell carcinoma of the esophagus: a clinicopathological study

Cited by 4 publications

References 22 publications

Increased risk of second primary tumours in patients with oesophageal squamous cell carcinoma: a nationwide study in a Western population

Increased risk of second primary tumours in patients with oesophageal squamous cell carcinoma: a nationwide study in a Western population

Screening for head and neck second primary tumors in patients with esophageal squamous cell cancer: A systematic review and meta‐analysis

Mutational profile of TP53 in esophageal squamous cell carcinoma associated with chagasic megaesophagus

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