Autogenous fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion: morbidity, mortality and microbiological response

Gadelha, Diego Nery Benevides; Melo, Márcio Camargo de; Oliveira, Thárcia Kiara Beserra de; Brandt, Carlos Teixeira

doi:10.1590/s0102-86502013000400010

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…In case of severe peritonitis the pathological process is fully realized, leading to a total exhaustion of the protective and compensatory mechanisms [5]. Such processes can be observed macroscopically, suppuration is formed between the bowel loops and omentum, numerous micro abscesses occur under the liver capsule [10,18]. Such pathological changes among rats with peritonitis are typical for this pathology.…”

Section: Larvae Survivalmentioning

confidence: 99%

Pathological anatomic changes among laboratory rats in case of experimental infection with the larvae of the nematode Eustrongylides excisus (Nematoda: Dioctophymatidae)

Honcharov¹

2020

Bìol. Tvarin

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The aim of the research was to model the experimental infection in laboratory rats with the larvae of the nematodes Eustrongylides excisus and documenting the macroscopic changes in organs and tissues of the animals. With a purpose of creating the best conditions for the nematodes larvae's survival the animals were divided into 4 groups. The first group included intact animals. The rats of groups II and III were orally given the 1 % chlorine hydride solution in the amount of 0.5 and 1 ml respectively. Group IV was a control. The rate of the larvae survival in groups I, II and III counted, respectively, 18, 38 and 52 % of the general amount of the larvae put into the organisms of the rats. Among the invaded rats next changes of the clinical conditions were noticed: general weakness, absence of appetite, pain and tension in the abdominal wall etc. After euthanasia and followed autopsy the symptoms of serofibrous (20 % of the invaded animals) and fibrinopurulent (66.6 %) peritonitis were noticed. It also showed the signs of the enteral failure syndrome (73.3 %) and the abdominal layers adhesion (86.6 %). Microabscesses under the liver capsule were noticed as well, in 26.6 % of the experimentally infected rats. Pathological changes in the thoracic cavity organs, in part in the heart (pericard and heart sac hemorrhages) and in the lungs (congestive hyperemia and pulmonary edema) have been found in 60 % cases, and in kidneys in 73.3 % cases. Symptoms of catarrhal and hemorrhagic gastritis were observed. The positive correlative connection between the parasitic survival percentage in the organisms of rats and the depth and difficulty of the pathological process was determined.

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Section: Larvae Survivalmentioning

confidence: 99%

Pathological anatomic changes among laboratory rats in case of experimental infection with the larvae of the nematode Eustrongylides excisus (Nematoda: Dioctophymatidae)

Honcharov¹

2020

Bìol. Tvarin

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Severe autogenously fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion. Response to intra peritoneal moxifloxacin combined with dexamethasone

Melo

Gadelha²,

Oliveira

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate the treatment outcome of severe peritonitis in rats submitted to permanent bilateral carotid occlusion (PBCO). METHODS:Sixteen Wistar rats (mean age of 8.5 months) with PBCO underwent autogenously fecal peritonitis, and were treated with moxifloxacin combined with dexamethasone, and followed-up for 45 days. Ten rats (mean age five months) without PBCO were used as a control group. The variables were expressed by their mean and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee. RESULTS:There was a significant increase (p=0.0002) in the mortality and morbidity in older rats that underwent PBCO (study group). However, even among the survival rats presenting with severe residual abscesses both in the abdomen and thorax cavities, they present an almost normal life. CONCLUSIONS:The treatment of severe autogenously fecal peritonitis with intraperitoneal moxifloxacin combined with dexamethasone was very effective in young rats without permanent bilateral carotid occlusion. The treatment reached reasonable results in older rats with PBCO, even considering residual abscesses on abdomen and thorax. Older age was the greater risk factor for the outcome of the treatment of severe peritonitis. Sepsis remains a challenging situation, especially in elderly.Key words: Peritonitis. Quinolones. Dexamethasone. Therapy. Rats. Severe autogenously fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion.Response to intra peritoneal moxifloxacin combined with dexamethasone

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Effect of cerium oxide nanoparticles on sepsis induced mortality and NF-κB signaling in cultured macrophages

et al. 2015

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Autogenous fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion: morbidity, mortality and microbiological response

Cited by 4 publications

References 24 publications

Pathological anatomic changes among laboratory rats in case of experimental infection with the larvae of the nematode Eustrongylides excisus (Nematoda: Dioctophymatidae)

Pathological anatomic changes among laboratory rats in case of experimental infection with the larvae of the nematode Eustrongylides excisus (Nematoda: Dioctophymatidae)

Severe autogenously fecal peritonitis in Wistar rats with permanent bilateral carotid occlusion. Response to intra peritoneal moxifloxacin combined with dexamethasone

Effect of cerium oxide nanoparticles on sepsis induced mortality and NF-κB signaling in cultured macrophages

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