Effects of dorsal root ganglion destruction by adriamycin in patients with postherpetic neuralgia

He, Chuan; yi-ran, Luo; hao-xiong, Nie

doi:10.1590/s0102-86502012000600008

Cited by 8 publications

(5 citation statements)

References 20 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[ 4 ] Reports indicated that dorsal root ganglion destructed by 0.25% Adriamycin injection in paravertebral intervertebral foramen could effectively relieve pain of patients with PHN. [ 7 ] In this case, we found that injection of Adriamycin to Gasserian ganglion successfully relieved the trigeminal nerve PHN as well. We used CT guidance to make sure that the needle arrives at the foramen ovale and Adriamycin injected to the ideal area.…”

Section: Discussionmentioning

confidence: 71%

Gasserian ganglion injected with Adriamycin successfully relieves intractable trigeminal nerve postherpetic neuralgia for an elderly patient

Zheng

Song²,

Liu³

2018

Medicine

View full text Add to dashboard Cite

RationaleEffective treatments for trigeminal nerve postherpetic neuralgia (PHN) are limited. Adriamycin (doxorubicin) has been applied to the treatment of neuropathic pain. This study reports a new treatment: Adriamycin injected to Gasserian ganglion for an elderly patient with the intractable trigeminal nerve PHN.Patient concernsA 75-year-old man complained of lancing, burning pain in the right mandibular branch of the trigeminal nerve (V3) for 3 months after rash eruption.DiagnosesTrigeminal nerve PHN.InterventionsApproximately 0.5 mL of 0.25% Adriamycin and 20 mg methylprednisolone injected to Gasserian ganglion through the foramen ovale with computer tomography guidance.OutcomesThe visual analog scale was 10 of 100 throughout the 1-month follow-up, and oxcarbazepine had also been tapered. The patient remained free of pain at the 12-month follow-up.LessonsThe treatment of Adriamycin injection to Gasserian ganglion is effective and safe, and may be considered as an alternative treatment for trigeminal nerve PHN. However, more research is needed to verify the validity.

show abstract

Section: Discussionmentioning

confidence: 71%

Gasserian ganglion injected with Adriamycin successfully relieves intractable trigeminal nerve postherpetic neuralgia for an elderly patient

Zheng

Song²,

Liu³

2018

Medicine

View full text Add to dashboard Cite

show abstract

“…The agents currently used for chemical neurolysis are alcohol, phenol, adriamycin, and methylene blue. Adriamycin mainly acts on the dorsal root ganglia and has a slow onset [ 22 ], while methylene blue has a short acting time. Alcohol acts by denaturing proteins, extracting fatty substances, and precipitating lipoproteins and mucoproteins, damaging both Schwann and nerve cells, and resulting in Wallerian degeneration.…”

Section: Discussionmentioning

confidence: 99%

Splanchnic nerve neurolysis via the transdiscal approach under fluoroscopic guidance: a retrospective study

et al. 2022

View full text Add to dashboard Cite

Background Neurolytic celiac plexus block (NCPB) is a typical treatment for severe epigastric cancer pain, but the therapeutic effect is often affected by the variation of local anatomical structures induced by the tumor. Greater and lesser splanchnic nerve neurolysis (SNN) had similar effects to the NCPB, and was recently performed with a paravertebral approach under the image guidance, or with the transdiscal approach under the guidance of computed tomography. This study observed the feasibility and safety of SNN via a transdiscal approach under fluoroscopic guidance. Methods The follow-up records of 34 patients with epigastric cancer pain who underwent the splanchnic nerve block via the T11-12 transdiscal approach under fluoroscopic guidance were investigated retrospectively. The numerical rating scale (NRS), the patient satisfaction scale (PSS) and quality of life (QOL) of the patient, the dose of morphine consumed, and the occurrence and severity of adverse events were recorded preoperatively and 1 day, 1 week, 1 month, and 2 months after surgery. Results Compared with the preoperative scores, the NRS scores and daily morphine consumption decreased and the QOL and PSS scores increased at each postoperative time point ( P < 0.001). No patients experienced serious complications. Conclusions SNN via the transdiscal approach under flouroscopic guidance was an effective, safe, and easy operation for epigastric cancer pain, with fewer complications.

show abstract

“…Seldom trials take this measure to treat PHN and only one is found. [22] Besides, the effectiveness and safety of nerve destruction have not been confirmed. PRF is the improvement of radiofrequency thermocoagulation.…”

Section: Discussionmentioning

confidence: 99%

The effect of interventional pain management on treating postherpetic neuralgia

et al. 2019

View full text Add to dashboard Cite

Background: Herpes zoster (HZ) is identified to induce postherpetic neuralgia (PHN) which is difficult to cure. PHN-related pain brings patients not only physical discomfort but also mental depression and anxiety. Currently, the main purpose of PHN treatment is to reduce patients’ pain. Now treatment combining some international pain management and drug therapy has come up. Aims and Objective: This study aims to evaluate the effect of interventional management through meta-analysis. Materials and Methods: Interventional pain management was defined as a direct strategy on nerve through physical or chemical method. Drug therapy was always regarded as control. Potentially relevant articles were searched in PubMed, EMBASE, and the Cochrane Library through key words by consensus. Pain severity was evaluated by a validated visual analog scale (VAS). Moreover, the weighted mean difference was used to calculate pain intensity. Some trails recorded the efficiency rate and odds ratio was used to calculate the effectiveness. Statistical heterogeneity was measured by the value of I 2 , and when statistical I 2 > 50%, subgroup analysis was used to seek for the source of heterogeneity. Results: Pulsed radiofrequency (PRF) combined with medication reduced the VAS scores at 1, 2, 4, and 8 weeks after treatment. The nerve block combined with medication reduced VAS scores at 8 weeks after treatment, but there is no difference between the results of medication alone at 1, 2, and 4 weeks after treatment. Conclusion: The interventional mean of PRF combined with medication has a good effect on PHN. The effect of nerve block combined with medication on PHN seems to be the same as that of medication alone. Besides, a long period with high-quality randomized controlled trial should be done to verify the results.

show abstract

Effects of dorsal root ganglion destruction by adriamycin in patients with postherpetic neuralgia

Cited by 8 publications

References 20 publications

Gasserian ganglion injected with Adriamycin successfully relieves intractable trigeminal nerve postherpetic neuralgia for an elderly patient

Gasserian ganglion injected with Adriamycin successfully relieves intractable trigeminal nerve postherpetic neuralgia for an elderly patient

Splanchnic nerve neurolysis via the transdiscal approach under fluoroscopic guidance: a retrospective study

The effect of interventional pain management on treating postherpetic neuralgia

Contact Info

Product

Resources

About