Combination hyperbaric oxygen and temozolomide therapy in c6 rat glioma model

Dağıstan, Yaşar; Karaca, Ismail; Bozkurt, Erol Rüştü; Ozar, Engin; Yağmurlu, Kaan; Toklu, Akın Savaş; Bılır, Ayhan

doi:10.1590/s0102-86502012000600005

Cited by 20 publications

(19 citation statements)

References 16 publications

(14 reference statements)

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“…Actually, this phenomenon has been proved by our team recently, in this study we found cancer stem cells, including glioma, hepatom and lung cancer, can be induced through dedifferentiation in hypoxia 30 , 31 . In contrast, as an effective way to alleviate a hypoxic environment, hyperoxia promotes the sensitivity of glioma cells to TMZ by decreasing the expression of MGMT, ABCG2 and Ki67 and inducing a higher cell apoptosis rate, resulting in an extended survival time for glioma patients 15 , 16 , 18 , 19 , 32 . However, the detailed mechanism requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

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HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels

Wang

Wan

Xiong

et al. 2017

Sci Rep

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Chemotherapy plays a significant role in glioma treatment; however, it has limited effectiveness in extending the life expectancies of glioma patients. Traditional studies have attributed this lack of efficacy to glioma stem cells (GSCs) and their high resistance to chemotherapy, and hypoxia worsens this issue. In contrast, hyperoxia effectively alleviates hypoxia in glioma and sensitizes glioma cells to chemotherapy. In a summary of traditional studies, the majority of researchers overlooked the influence of hypoxia on differentiated cells because they only focused on the maintenance of GSCs stemness, which thus resulted in chemoresistance. Because of this background, we hypothesized that GSCs may be induced through dedifferentiation under hypoxic conditions, and hypoxia maintains GSCs stemness, which thus leads to resistance to chemotherapy. In contrast, hyperoxia inhibits the dedifferentiation process and promotes GSCs differentiation, which increases the sensitization of glioma cells to chemotherapy. Hypoxia-inducible factor-1α (HIF1α) contributes substantially to the stemness maintenance of GSCs and resistance of glioma to chemotherapy; thus, we investigated whether HIF1α regulates the resistance or sensitization of glioma cells to chemotherapy in different oxygen levels. It highlights a novel viewpoint on glioma chemosensitivity from the transformation between dedifferentiation and differentiation in different oxygen levels.

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Section: Discussionmentioning

confidence: 99%

“…These findings were in accordance with a recent study conducted by Dagistan et al . 19 , in which the combination of TMZ and HBO significantly decreased the levels of Ki67 in tumor tissue. However, the detailed mechanism requires further investigation.…”

Section: Introductionmentioning

confidence: 96%

HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels

Wang

Wan

Xiong

et al. 2017

Sci Rep

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“…In recent years, many studies have been performed in order to elucidate possible mechanisms through which non-steroidal antiinflammatory drugs (NSAID) are able to reduce tumors, since there are reports which indicate that chronic inflammation may contribute to the cancer progress [1,2]. Recently, some studies have suggested that an inflammatory microenvironment may facilitate carcinogenesis and tumor angiogenesis, furthermore, scientific literature describes a higher expression of cyclooxygenase (COX) in tumor tissues [3] which leads to the hypothesis that the use of NSAIDs may contribute to control tumor progression, thus, increasing the efficacy of cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Ketoprofen-loaded pomegranate seed oil nanoemulsion stabilized by pullulan: Selective antiglioma formulation for intravenous administration

Ferreira

Cervi

Gehrcke

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…However, the effects observed in patients were diverse (from complete recovery or reduction of tumour mass to progression of disease) and also difficult to interpret, due to the small number of patients in each of the treatment groups. To assess the impact of HBOT on the therapeutic effect of temozolomide (TMZ), Dagistan et al [ 94 ] conducted an experimental study on rats that had been injected with C6 glioma cells. The results of this study suggested that the combination of TMZ and HBO significantly diminishes cell proliferation and angiogenesis and that it also stimulates apoptosis of glioma cells, in comparison with the control group and the group treated with TMZ alone.…”

Section: Hyperbaric Oxygen Therapy In Malignant Glioma Treatmentmentioning

confidence: 99%

Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours

2016

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Hyperbaric oxygen (HBO) therapy is widely used as an adjunctive treatment for various pathological states, predominantly related to hypoxic and/or ischaemic conditions. It also holds promise as an approach to overcoming the problem of oxygen deficiency in the poorly oxygenated regions of the neoplastic tissue. Occurrence of local hypoxia within the central areas of solid tumours is one of the major issues contributing to ineffective medical treatment. However, in anti-cancer therapy, HBO alone gives a limited curative effect and is typically not applied by itself. More often, HBO is used as an adjuvant treatment along with other therapeutic modalities, such as radio- and chemotherapy. This review outlines the existing data regarding the medical use of HBO in cancer treatment, with a particular focus on the use of HBO in the treatment of brain tumours. We conclude that the administration of HBO can provide many clinical benefits in the treatment of tumours, including management of highly malignant gliomas. Applied immediately before irradiation, it is safe and well tolerated by patients, causing rare and limited side effects. The results obtained with a combination of HBO/radiotherapy protocol proved to be especially favourable compared to radiation treatment alone. HBO can also increase the cytostatic effect of certain drugs, which may render standard chemotherapy more effective. The currently available data support the legitimacy of conducting further research on the use of HBO in the treatment of malignancies.

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Combination hyperbaric oxygen and temozolomide therapy in c6 rat glioma model

Abstract: The combination of hyperbaric oxygen with temozolomide produced an important reduction in glioma growth and effective approach to the treatment of glioblastoma.

Cited by 20 publications

References 16 publications

HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels

HIF1α regulates glioma chemosensitivity through the transformation between differentiation and dedifferentiation in various oxygen levels

Ketoprofen-loaded pomegranate seed oil nanoemulsion stabilized by pullulan: Selective antiglioma formulation for intravenous administration

Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours

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