Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats

Rêgo, Amália Cínthia Meneses; Araújo‐Filho, Irami; Azevedo, Ítalo Medeiros; Jácome, Daniel Tôrres; Ramalho, Rachel de Alcântara Oliveira; Medeiros, Aldo Cunha

doi:10.1590/s0102-86502010000100004

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…RYGB is a restrictive and malabsorptive bariatric procedure. In RYGB, a portion of the stomach is used to create a small gastric pouch, allowing the digestive system to bypass the larger portion of the stomach and a portion of the small intestine ( Rêgo et al, 2010 ). These portions are no longer used in the storage or processing of food, leading to decreased caloric consumption and absorption ( Rao et al, 2010 ).…”

Section: Resultsmentioning

confidence: 99%

“…Other studies have also shown that bariatric surgery resulted in calcium and vitamin D malabsorption, which has led to bone loss and high serum hyperparathyroidism ( Rêgo et al, 2010 ; Tessier et al, 2019 ). Data suggested the possibility of the suppression of bone formation, which indicates that future preventions of bone loss are a potential target for patients undergoing bariatric surgery.…”

Section: Resultsmentioning

confidence: 99%

“…In Rego et al, the article interestingly iterated that the reuptake of technetium-99 m pertechnetate by the liver was significantly lowered in RYGB rats compared to the controlled rats ( Rêgo et al, 2010 ). There are significantly more 99 mTcO4− in the stomach and small intestine in colectomy rats compared to sham and control groups.…”

Section: Resultsmentioning

confidence: 99%

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Effects of bariatric surgery on drug pharmacokinetics—Preclinical studies

Mercado

Pham²,

Wang³

et al. 2023

Front. Pharmacol.

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With the rising worldwide obesity rates, bariatric surgeries are increasing. Although the surgery offers an effective treatment option for weight loss, the procedure causes dramatic physiological and metabolic changes. Animal models in rodents provide a valuable tool for studying the systemic effects of the surgery. Since the surgery may significantly influence the pharmacokinetic properties of medications, animal studies should provide essential insight into mechanisms underlying changes in how the body handles the drug. This review summarizes research work in rodents regarding the impact of standard bariatric procedures on pharmacokinetics. A qualitative literature search was conducted via PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE. Studies that examined bariatric surgery’s effects on drug pharmacokinetics in rodent models were included. Clinical studies and studies not involving drug interventions were excluded. A total of 15 studies were identified and assessed in this review. These studies demonstrate the possible impact of bariatric surgery on drug absorption, distribution, metabolism, excretion, and potential mechanisms. Pharmacokinetic changes exhibited in the limited pre-clinical studies highlight a need for further investigation to fully understand the impact and mechanism of bariatric surgery on drug responses.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effects of bariatric surgery on drug pharmacokinetics—Preclinical studies

Mercado

Pham²,

Wang³

et al. 2023

Front. Pharmacol.

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“…The biodistribution of Na 99m TcO 4 has an important clinical significance in scintigraphic examinations, in which tissues capture the radiopharmaceutical to produce images. Several physiological, pathological and therapeutic conditions have been associated with changes in the activity Na 99m TcO 4 such as bariatric surgery, regular administration of herbal medicines, intestinal resection, inflammation, etc 11,18,19 . The mastruz was not able to alter the biodistribution in organs studied.…”

Section: Discussionmentioning

confidence: 99%

Biodistribution of sodium pertechnetate and biochemical parameters in experimental osteoporosis in rats treated with extract of Chenopodium ambrosioides L (mastruz)

Soares

Trindade²,

Sampaio³

et al. 2014

J Surg Clin Res

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The aim of this study was to evaluate the effect of treatment with Chenopodium ambrosioides L (mastruz) hydroalcoholic extract in rats with osteoporosis on the biodistribution of sodium pertechnetate (Na99mTcO4) and biochemical parameters. Methods: Ten rats underwent ovariectomy to induce osteoporosis. The first group (n = 5) received no treatment, the second group (n = 5) received 50mg HaME for thirty days. After finishing the treatment the animals had been anesthetized and injected 0.1 mL (0.66 MBq) of Na 99 mTcO4 the femural vein. After 30 minutes, blood was collected for dosages, and then the animals were killed by an overdose of anesthetic (thiopental 100mg/kg) and removed the heart, lungs, stomach, femur, kidneys, liver, intestine and thyroid to calculate the percentage of radioactivity per gram of tissue (% ATI/ g) of each organ. Results: There was no significant difference in any of the organs analyzed, but in all of them, except in the intestine, the uptake of Na 99 mTcO4 was higher in the group treated with mastruz. Biochemical parameters showed a significant increase in lactate dehydrogenase, total cholesterol, and aspartate aminotransferase. These results allow us to state that mastruz may have hepatotoxic effect. Conclusion: Treatment with mastruz in rats with osteoporosis does not alter the biodistribution of the radiopharmaceutical Na 99m TcO 4 and showed some hepatotoxicity

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Challenges and Pitfalls of Experimental Bariatric Procedures in Rats

Fischer¹,

Clemens²,

Gehrig³

et al. 2012

Obes Facts

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Introduction: The impact of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on obesity and obesity-related diseases is unquestionable. Up to now, the technical descriptions of these techniques in animals/rats have not been very comprehensive. Methods: For SG and RYGB, operating time, learning curve, and intraoperative mortality in relation to weight of the rat and type of anesthesia were recorded. Furthermore, a review of the literature on experimental approaches towards SG and RYGB in rats was carried out, merging in a detailed technical description for both procedures. Results: The data presented here revealed that the mean operating time for SG (69.4 ± 22.2 min (SD)) was shorter than for RYGB (123.0 ± 20.7 min). There is a learning curve for both procedures, resulting in a reduced operating time of up to 60% in SG and 35% in RYGB (p < 0.05; t-test). However, with increased weight, operating time increases to about 80 min for SG and about 120 min for RYGB. Obese rats have an increased intraoperative mortality rate of up to 50%. After gaseous anesthesia the mortality can be even higher. The literature search revealed 40 papers dealing with SG and RYGB in rats. 18 articles (45%) contained neither photographs nor illustrations; 14 articles (35%) did not mention the applied type of anesthesia. The mortality rate was described in 15 papers (37.5%). Conclusion: Experimental obesity surgery in rats is challenging. Because of the high mortality in obese rats operated under gaseous anesthesia, exercises to establish the techniques should be performed in small rats using intraperitoneal anesthesia.

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Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats

Cited by 4 publications

References 22 publications

Effects of bariatric surgery on drug pharmacokinetics—Preclinical studies

Effects of bariatric surgery on drug pharmacokinetics—Preclinical studies

Biodistribution of sodium pertechnetate and biochemical parameters in experimental osteoporosis in rats treated with extract of Chenopodium ambrosioides L (mastruz)

Challenges and Pitfalls of Experimental Bariatric Procedures in Rats

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