Histological and histomorphometric evaluation of the retina of mice infected with Schistosoma mansoni in its hepatosplenic form

Remígio, Maria Cecília de Aguiar; Brandt, Carlos Teixeira; Filho, Nicodemos Teles de Pontes; Albuquerque, Mônica Camelo Pessôa de Azevedo

doi:10.1590/s0102-86502009000600014

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…However, this is not the case in our study, where hamsters were systemically infected in a trial to imitate the natural route of infection that occurs in humans. A similar study (Remígio et al , 2009) detected a retinal granuloma in only one case with otherwise normal architecture and thickness of the retina. They suggested that this may be due to a low level of parasite infection.…”

Section: Discussionmentioning

confidence: 59%

Ocular pathological changes in hamsters experimentally infected withSchistosoma mansoni

Ismail¹,

Ashour²,

Rayia³

et al. 2016

J. Helminthol.

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Ocular lesions have been reported in patients with schistosomiasis; however, the problem with studying schistosomal infection of the human eye is that biopsies are almost impossible to take, and histopathological examination of suspicious lesions can only be undertaken post-mortem or after enucleation. This work aimed to study the possible effects and pathogenesis of schistosomiasis on the eye. This study involved 55 hamsters; five hamsters remained non-infected and the remaining 50 hamsters were infected with Schistosoma mansoni cercariae. Infected hamsters were sacrificed on weeks 8, 12, 16 and 20 post-infection (pi). Eye sections were prepared and stained for histopathological and immunohistochemical studies. Histopathological changes detected in hamsters infected after 16 and 20 weeks included looseness and oedema of the innermost retinal layers together with hyperplastic polypoid growth. Neither eggs nor granulomata were detected in eye sections throughout the experimental period. Deposition of S. mansoni antigen was revealed in 35% of infected hamsters. Later, on weeks 16 and 20 pi, moderate subepithelial conjuctival deposits and marked subchoroidal and scleral deposition were detected. In conclusion, the deposition of schistosomal antigen and immune complexes may play a pivotal role in the ocular changes that occur in schistosomiasis, even in the absence of detectable Schistosoma eggs. Schistosomiasis should be suspected in cases with unexplained ophthalmological findings, especially in endemic areas.

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Section: Discussionmentioning

confidence: 59%

Ocular pathological changes in hamsters experimentally infected withSchistosoma mansoni

Ismail¹,

Ashour²,

Rayia³

et al. 2016

J. Helminthol.

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show abstract

“… 2 , 4 Interestingly, these could not be demonstrated on prior MRI scans, probably because of their small size. Remigio et al 5 have previously reported a presumed retinal granuloma in one out of 25 (4%) Swiss mice infected with S. mansoni (exposing the tails to a suspension of 40 cercariae). Ismail et al 6 found deposition of S. mansoni antigen in the eyes of 17 of 50 (35%) hamsters infected by S. mansoni cercarie.…”

mentioning

confidence: 99%

Characterisation of ocular involvement in an experimental model of neuroschistosomiasis mansoni

Fidelis

Brasileiro-Filho

Santos

et al. 2019

Mem. Inst. Oswaldo Cruz

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The Global Burden of Disease Study 2010 listed schistosomiasis among the leading 100 causes of death in Brazil, responsible for 3.6% of the estimated total of deaths globally. Eye and adnexa are very rarely affected by schistosomiasis mansoni, with limited documentation of ocular pathology in this setting. This short communication reports ocular histolopathological findings in a murine model of neuroschistosomiasis mansoni. Lesions were found in the bulbar conjunctiva, lacrimal gland, choroid and corneoscleral limbus.

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Effect of memantine: A NMDA receptor blocker, on ethambutol-induced retinal injury

Abdel-Hamid

Firgany

Ali

2016

Annals of Anatomy - Anatomischer Anzeiger

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Histological and histomorphometric evaluation of the retina of mice infected with Schistosoma mansoni in its hepatosplenic form

Abstract: The absence of findings in this study does not exclude that hemodynamic and autoregulation changes associated with hepatosplenic schistosomiasis could be correlated to retinal manifestations. It is necessary that other methods with a high parasite infection should be performed.

Cited by 3 publications

References 12 publications

Ocular pathological changes in hamsters experimentally infected withSchistosoma mansoni

Ocular pathological changes in hamsters experimentally infected withSchistosoma mansoni

Characterisation of ocular involvement in an experimental model of neuroschistosomiasis mansoni

Effect of memantine: A NMDA receptor blocker, on ethambutol-induced retinal injury

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