Evaluation of healing prosthetic materials polyester mesh resorbable film and collagen elastin matrix /polypropylene used in rabbits abdominal wall defects

Abstract

PURPOSE: To compare polyester with absorbable layer prosthesis with collagen-elastin/polypropylene prosthesis in the repair of abdominal wall defects. METHODS: The 16 studied rabbits were divided in groups A and B (euthanized on the 30th and 60th days, after the implant of the mesh). The animals underwent laparotomy and received a 2cm wall "defect" on each side of the Alba linea. The repair was made with the suture of a polyester mesh with absorbable film on the left side of the Alba Linea and with collagen-elastin/polypropylene mesh on the right side. Adherences were classified according to Nair Score and microscopic evaluation observing types I and III collagen formation and other immunohistochemical analyses. RESULTS: There were no significant differences in adhesion formation. The collagen type I showed higher deposition in polyester with absorbable layer. In group B, the difference between the meshes was significant, with higher collagen III deposition in polyester with absorbable layer (60º P.O.). About the metalloproteinases, the presence of MMP -1 and MMP-8 were about the same; the expression of MMP-13 increased near to the 60th day. CONCLUSIONS: There is no significant difference between the two meshes in adhesion formation and immunohystochemical evaluation. The polyester mesh resorbable film presented a higher deposition of collagen.

Assessment of adhesion formation after laparoscopic intraperitoneal implantation of Dynamesh IPOM mesh

“…The external layer of these meshes is often built of polypropylene or polyester, while the inner layer is made of collagen (Parietex), cellulose (Proceed), expanded polytetrafluoroethylene (ePTFE, dual-mesh) or polyglactin 910. Even though these materials were designed specifically to prevent adhesions, in actual practice they adhere to viscera on 18-57% of their surface [12–16]. …”

Comparative study between polypropylene and polypropylene/poliglecaprone meshes used in the correction of abdominal wall defect in rats

“…Several studies have evaluated the use of intraperitoneal mesh [5][6][7][8][9] . Baroncelli et al 7 comparing the healing process between the Parietex ® and Surgisis ® meshes in the correction of abdominal wall defects in rabbits, observed that the Parietex ® and Surgisis ® were effective in correcting the defects.…”

“…Araújo et al 8 assessed the intraperitoneal use of polyester with collagen and polypropylene with polyglycolic acid meshes and had the same repair results in the abdominal wall defects of rabbits. Shulz et al 9 , compared absorbable polyester with collagen/elastine/polypropylene meshes to repair injuries to the abdominal wall of rabbits, and had no significant differences on its use.…”

Polypropylene meshes and other alloplastic implants for soft tissue and cartilage nasal reconstructive surgery – a literature review

“…The presence of metalloproteinases was approximately the same, expression of MMP-1, MMP-8 and MMP-13 were studied, with low difference in MMP-13 at 60 days. The expression of MMP-13 increased in the polyester mesh with absorbable layer prosthesis group 43 .…”