Bilioduodenal anastomosis in rats with extra-hepatic biliary obstruction is followed by lesions ischemia and reperfusion-induced

Abstract

The results demonstrated that surgical biliary decompression in obstructive jaundice is followed by alterations related to hepatic ischemia- reperfusion.

Influence of biliary anastomosis on recovery from secondary biliary cirrhosis

“…The animals that died after a bile shunt were subjected to autopsies, which did not indicate any mechanical or infectious causes, dehiscence of the anastomoses, or abdominal bleeding that would justify death. On the basis of this information and on the data of other studies, we deduce that the high mortality rate found in the present study might have been related to the different degrees of the hepatocellular lesion resulting from the BO [34,35], metabolic, anesthetic, and hemodynamic effects [6,36] and the hepatic injury of ischemia and reperfusion [37,38].…”

Influence of Biliary Drainage on the Repair of Hepatic Lesions in Biliary Fibrosis

“…Some of the recorded adverse effects of biliodigestive anastomosis include the occurrence of enterobiliary reflux, contamination of the biliary duct, and increased inflammation in the portal spaces, especially after BD [8,[29][30][31]. The few studies assessing hepatobiliointestinal flow by scintigraphy with radioactive isotopes show stasis in the excluded Roux-en-Y loop and a higher incidence of cholangitis [7,10,32].…”

“…The postoperative mortality was high (BD: 30.7%, BJ: 63%, and BJD: 75%) and was associated with the duration of surgery and the levels of cholestasis, as the surviving animals had levels of total and direct bilirubin that were lower than those of the CBO group. The elevated and varied coefficients of mortality, especially in the early postoperative period, may have been related to different degrees of hepatocellular lesions caused by biliary obstruction [8], the anesthetic agents utilized, and the phenomena of ischemia and reperfusion of the liver after biliary decompression [30,33].…”

Nitrotyrosine Density of Rabbit Urinary Bladder Muscle and Mucosa Measured via Western Blotting and 96-Well Plate Analysis

“…Ischemic damage causes the mitochondrial damage and the sarcoplasmic reticulum to release calcium from their binding sites [16–21]. This leads to an increase in cytosolic calcium levels and ultimately an increase in oxidative stress.…”