1.8 cineole decreases gastric compliance in anesthetized rats

Abstract

PURPOSE: To study the effect of 1,8 cineoleee components of the essencial oil of Croton nepetaefolius - plant of North-East of Brasil, used in the popular medicine for riots of the gastrointestinal tract - on the motor behavior of the gut of Wistar rats. METHODS: Used 16 male animals under jejun of 24h weighing 300-350g. The effect of 1.8 cineoleee (1 or 3mg/Kg) on gastric compliance had been lead in anaesthetized rats. The variations of the gastric volume (GV), had been measured by plethysmography, while AP, HR and CVP had been monitored continuously by a digital system of data acquisition. RESULTS: Observe reduction of the GV, which was significant on 30, 40, 50 and 60min after treatment (2.0±0.1; 1.9±0.1; 1.8±0.1 and 1.7±0.1mL, versus 2.1±0.2mL). The AP presented significant fall after the administration of 1.8 cineoleee, remaining thus during 60min of monitorization (87.9±7.7; 87.6±7.1; 87.9±6.4; 87.8±5.7; 86.0±5.5 and 87.7±6.0mmHg, respectively versus 94.4±6.2 mmHg), as well as the HR (366.3±13.4; 361.7±11.5; 357.3±10.4; 353.0±10.4; 348.3±11.1 and 350.4±13.7bpm, respectively versus 395.2±11.1bpm). The CVP did not suffer significant variations after treatment. CONCLUSION: Observe the 1.8 cineoleee reduces the gastric compliance in anaesthetized rats besides presenting effect hipotensor and bradicardic; probably for direct action on the gastrointestinal and vascular smooth muscel and moduling the autonomic nervous system.

The Effect of 1,8-Cineole Inhalation on Preoperative Anxiety: A Randomized Clinical Trial

“…We found that inhalation of 1,8-cineole and eucalyptus significantly decreased SBP due to the anxiolytic effect of 1,8-cineole, but the differences between groups were not significant. 1,8-Cineole administration has also been shown to reduce gastric compliance, arterial pressure, and cardiac frequency in anesthetized rats [27]. Furthermore, a high dose (10 mg/kg) of 1,8-cineole was associated with hypotension and bradycardia in both anesthetized and conscious rats [20].…”

Characterization of Inhibitory Effectiveness in Hyperpolarization-Activated Cation Currents by a Group of ent-Kaurane-Type Diterpenoids from Croton tonkinensis

“…Previous studies have demonstrated that intravenous injection with the essential oil of C. zehntneri or nepetaefolius could induce rapid and dose-dependent hypotension and bradycardia [2][3][4].…”

Anthelmintic activity in vitro of Citrus sinensis and Melaleuca quinquenervia essential oil from Cuba on Haemonchus contortus

“…It is considered an unwanted invasive species in Zapata Swamp, Matanzas-Cuba, causing losses to plant biodiversity. Its essential oils have been evaluated and interesting effects were found, such as anti-inflammatory (Neves et al, 2007), antimalarial (Fernández-Calienes et al, 2008), bactericidal and fungicidal (Pino et al, 2011), larvicidal and repellent (Amer and Mehlhorn, 2006;Leyva et al, 2012). Nevertheless, only a few studies have reported the efficacy of this plant against nematodes.…”