Efeitos iniciais da reposição volêmica com solução salina hipertônica a 7,5% na perfusão e oxigenação esplâncnica após choque hemorrágico

Cruz, Ruy J.; Yada-Langui, M. M.; Garrido, Alejandra G.; Figueiredo, Luiz Francisco Poli de; Silva, Maurício Rocha e

doi:10.1590/s0102-86502006000200010

Cited by 3 publications

References 18 publications

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Early Restoration of Cocaine-Induced Splanchnic Hypoperfusion in Anesthetized Dogs

Reis

Garrido

Cruz

et al. 2007

Journal of Investigative Surgery

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Although cardiovascular effects of cocaine have been well studied, little is known about its effects on splanchnic perfusion. We studied systemic and regional hemodynamic effects of acute cocaine intoxication in dogs under volatile anesthesia. Mechanically ventilated beagle dogs, randomized at 1.5% halothane (n = 7) or 2.25% sevoflurane (n = 7) anesthesia, received an intravenous bolus of cocaine (12 mg/kg over 5 min) followed by 0.22 mg/kg/min infusion over 30 min. They were observed for 60 min thereafter. Cardiac index (CI), heart rate (HR), mean arterial pressure (MAP), portal blood flow (PBF), gastric PCO(2) (gas tonometry), blood gases, and lactate and cocaine levels were assessed. Cocaine bolus promoted significant reductions in CI (~50%), HR (~20%), MAP (~20%), and PBF (~50%), accompanied by increase in systemic and splanchnic oxygen extractions and in gastric mucosal-arterial PCO(2) gradient. Those changes were maintained during cocaine infusion and returned to baseline values parallel to plasmatic cocaine clearance. Unlike other shock states, regional parameters, including gastric mucosal-arterial PCO(2) gradient, were restored before systemic variables. A possible local vasodilatory effect of volatile agents could play a role in this phenomenon. Cocaine infusion in anesthetized animals promoted marked systemic and regional hemodynamic derangement, which was rapidly reversible with decay of cocaine plasmatic concentration.

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Early Restoration of Cocaine-Induced Splanchnic Hypoperfusion in Anesthetized Dogs

Reis

Garrido

Cruz

et al. 2007

Journal of Investigative Surgery

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Efeitos da reposição volêmica com solução salina hipertônica a 3% na resposta inflamatória e na lesão orgânica após choque hemorrágico

Vincenzi¹

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Nota 1: CT (n=5), grupo-controle, sem indução de choque ou tratamento; RL (n=7), tratamento com 33 mL/Kg de Ringer lactato; SH 7,5% (n=7), tratamento com 4 mL/Kg de NaCl 7,5%; SH 3% (n=7), tratamento com 10 mL/Kg de NaCl 3%. Nota 2: BL, momento antes da indução do choque hemorrágico; H60, término do período de choque hemorrágico; T30, 30 minutos após o início da reposição volêmica. Nota 3: valores apresentados como media ± erro padrão da média. * p < 0,05 vs BL; † p < 0,05 vs H60; ‡ p < 0,05 vs CT; ¶ p < 0,05 vs RL.

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Blood Loss and Transcapillary Refill in Uncontrolled Treated Hemorrhage in Dogs

Sallum

Sinozaki

Calil

et al. 2010

Clinics

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OBJETIVE:This study evaluated retroperitoneal hematomas produced by bilateral injury of iliac arteries (uncontrolled hemorrhage), blood volume loss, transcapillary refill, the effects of volume replacement on retroperitoneal bleeding and the hemodynamic changes with and without treatment.METHODS:Initial blood volume was determined with Tc99m-labelled red cells, and bleeding was evaluated by means of a portable scintillation camera positioned over the abdomen. Previously splenectomized mongrel dogs (16.8 ± 2.2 kg) were submitted to hemorrhage for 30 minutes and randomized into three groups: I - no treatment (n=7); II - treatment with 32 mL/kg of Lactated Ringer’s for three to five minutes (n=7); and III - treatment with 4 mL/kg of 7.5% NaCl plus 6.0% dextran 70 for three to five minutes (n=7). They were studied for an additional 45 minutes.RESULTS:Volume replacement produced transitory recovery in hemodynamic variables, including mean pulmonary artery pressure, pulmonary capillary wedge pressure and cardiac index, with significant increase in dogs treated with 32 mL/kg of Lactated Ringer’s and 7.5% NaCl plus 6.0% dextran 70 (p<0.001, against no treatment), along with a decrease (p<0.001) in the systemic vascular resistance index. Groups II and III had significant initial decreases in hematocrit and hemoglobin. The treated dogs (groups II and III) presented rebleeding, which was greater during treatment with 32 mL/kg of Lactated Ringer’s (group II).CONCLUSIONS:Despite the rebleeding observed in treated groups, the utilization of hypertonic saline solution with dextran proved to be effective in the initial reanimation, producing evident transcapillary refill, while the Lactated Ringer’s solution produced capillary extravasation and was ineffective in the initial volume replacement in this model of uncontrolled hemorrhage.

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Efeitos iniciais da reposição volêmica com solução salina hipertônica a 7,5% na perfusão e oxigenação esplâncnica após choque hemorrágico

Cited by 3 publications

References 18 publications

Early Restoration of Cocaine-Induced Splanchnic Hypoperfusion in Anesthetized Dogs

Early Restoration of Cocaine-Induced Splanchnic Hypoperfusion in Anesthetized Dogs

Efeitos da reposição volêmica com solução salina hipertônica a 3% na resposta inflamatória e na lesão orgânica após choque hemorrágico

Blood Loss and Transcapillary Refill in Uncontrolled Treated Hemorrhage in Dogs

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