A study of the effects of pinealectomy on intestinal cell proliferation in infant newborn rats

Dalio, Marcelo Belini; Júnior, Luis Fernando Haikel; Dalio, Renato Belini; Pinto, André Péra Marques; Silva, Julio César Fernandes da; Vespúcio, Marcelo Vinícius Oliveira; Guimarães, Marco Aurélio; Garcia, Sérgio Britto

doi:10.1590/s0102-86502006000100005

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…In an experiment, the activation of the pineal gland function or the exogenous administration of melatonin led to a lower tumor occurrence rate, while pinealectomy had a stimulating effect on tumor growth. 14 Like all other hormones, melatonin produces its effect through special receptors of 2 types: melatonin receptors 1A (MelR1A) and melatonin receptors 1B (MelR1B). MelR1A and MelR1B have been found and fully characterized in the retina, suprachiasmatic nucleus, myometrium, placenta, granulosa and corpus luteum cells, immune cells, gastrointestinal tract, and skin.…”

Section: Discussionmentioning

confidence: 99%

Signaling Molecules of Human Skin Cells as the Targets for Injection Cosmetology

Gazitaeva¹,

Дробинцева²,

Prokopov³

et al. 2021

CCID

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Introduction: Skin aging is a natural process that cannot be stopped. However, there are many ways to help attenuate premature aging of the skin and reduce the signs that have already appeared. One of them is the subcutaneous administration of preparations containing a combination of hyaluronic acid, active amino acids, and peptides providing an anti-aging clinical effect. The purpose of this research is to study in vitro new signaling molecules with the anti-aging effects and influence of hyaluronic acid fillers on its expression. Methods: The study was conducted using cell cultures of human facial skin: 1) mixed culture of human facial skin keratinocytes and fibroblasts, and 2) culture of human facial skin keratinocytes enriched with Merkel cells. Immunocytochemistry, confocal microscopy and Western blot were used to identify markers of aging. Results: HA-Y and HA-S activated the expression of Klotho in the case of aging mixed culture of human skin keratinocytes and Merkel cells. The increase in expression of MTH-1 with aging of cultures provides evidence of activating defense mechanisms against reactive oxygen species that are accumulating with aging, under the action of HA-S and HA-Y. There was a statistically valid increase in the area of expression of melatonin receptor 1A and 1B markers when adding both HA-S and HA-Y to cultured cells. Conclusion: This investigation showed that the studied fillers have biological effects, testifying the stimulation of reparative processes in the skin under their control.

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Section: Discussionmentioning

confidence: 99%

Signaling Molecules of Human Skin Cells as the Targets for Injection Cosmetology

Gazitaeva¹,

Дробинцева²,

Prokopov³

et al. 2021

CCID

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“…However, the effects of melatonin on the cell proliferation of the small intestine in adult rats were investigated after pinealectomy by Callanghan (1995) and in infant rats by Dalio et al (2006). These studies demonstrated that without melatonin there is a hyperplasia of the intestinal epithelium caused by an increase in cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

Effects of Fasting at Different Stages of Lighting Regimen on the Proliferation of Jejunal Epithelial Cells During Rat Pup Weaning

Soares

Okada

Ayub

et al. 2009

The Anatomical Record

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The lifespan of intestinal epithelial cells is predetermined by the process of cell proliferation that occurs constantly in the crypt. The control of this process involves some endogenous factors, such as hormones, as well as exogenous factors, like food and natural light variations. These last two exogenous factors seem to be the major modulators of the cell proliferation process. Fasting treatment was conducted to assess the role of food and its effect on the metaphase index (MI) of the intestinal epithelium at different times and periods (light and dark) of the day. The effects of short-(5 hr) and long-term (25 hr) fasting on the MI in the jejunal epithelium of young rats were investigated at 09:00 h, 15:00 hr, 21:00 hr, and 02:00 hr using the arrested metaphases method. The present study demonstrates that 5 hr and 25 hr of fasting treatment decrease the MI at 09:00 hr. It was observed from MI analysis that there is an interaction between the fed/fasted status of the animal and the different times of the day. This result suggests that during the transition from youth to adulthood, the control of MI by the light/dark cycle seems to be more pronounced as compared with control by food intake at some periods of the day, although at other times food had a greater impact on the MI. Anat Rec, 292:955-959, 2009. V V C 2009 Wiley-Liss, Inc.

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Ultrastructural aspects of melatonin cytotoxicity on Caco-2 cells in vitro

Batista

Silva

Teixeira

et al. 2014

Micron

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A study of the effects of pinealectomy on intestinal cell proliferation in infant newborn rats

Abstract: As the increase of intestinal crypts epithelial cells in chronic group is a carcinogenesis predetermining factor, the understanding of the interaction between pineal gland and this event has great importance.

Cited by 4 publications

References 16 publications

Signaling Molecules of Human Skin Cells as the Targets for Injection Cosmetology

Signaling Molecules of Human Skin Cells as the Targets for Injection Cosmetology

Effects of Fasting at Different Stages of Lighting Regimen on the Proliferation of Jejunal Epithelial Cells During Rat Pup Weaning

Ultrastructural aspects of melatonin cytotoxicity on Caco-2 cells in vitro

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