Comparação entre os efeitos da mistura gelatina-resorcina-formaldeído e do N-butil-cianoacrilato em angiorrafias de veia jugular externa de coelhos (Oryctolagus cuniculus)

Abstract

OBJETIVO: Estudar comparativamente os efeitos de dois adesivos cirúrgicos adjutórios à técnica clássica de venorrafia, Colagel® e Histoacryl® no reforço da linha de sutura. MÉTODOS: Os procedimentos, conduzidos em 18 leporinos da raça Nova Zelândia, buscaram investigar a cicatrização de venorrafias pela evolução clínica dos animais, bem como a evolução da cicatrização das feridas cirúrgicas, macroscópica e microscopicamente. RESULTADOS: Os resultados obtidos mostraram, clínica e macroscopicamente, alterações de maior significado e, microscopicamente, predomínio de maior reação inflamatória nas suturas recobertas pelo Colagel®, comparativamente às mantidas como controle e às "protegidas'' pelo Histoacryl®. CONCLUSÕES: Houve retardo na cicatrização das feridas que receberam o Colagel® e similitude de resultados entre o grupo controle e as suturas recobertas pelo Histoacryl®.

Experimental comparative study in rabbits of three different ways of cartilage graft fixation: suture, gelatin-resorcin-formaldehyde and butyl-2-cyanoacrylate

“…There was a difference in the degree of inflammation among the three fixation types, GRF being less reactive. This result contradicts studies that observed a stronger tissue reaction with GRF, attributed to irritation caused by the formaldehyde [4,11,22]. The suture tended to provoke more reaction, but without statistical significance.…”

“…The inflammatory reaction to cyanoacrylate is caused by dependent reactions of the tissue oxygen [20]. Cyanoacrylate is an efficient adhesive for blood vessels [21,22], cornea [9], skin [23], and cartilage Ábone [24].…”

Estudo experimental comparativo entre o butil-2-cianoacrilato, a mistura gelatina-resorcina-formaldeído e sutura na estabilização de enxertos de cartilagem em coelhos

“…Cyanoacrylate inherent inflammatory reaction is caused by tissue oxygen-dependent reactions, instead of through the previous theory of polymerization exothermic reaction, explained by hidroperoxide lipid cell membranes polyunsaturated fatty acid transformation, which increase local arachidonic acid metabolism, triggering thromboxane and prostaglandin synthesis 15 . Cyanoacrylate proved to be an efficient adhesive for blood vessels 16,17 , corneas 10 , skin 18 , cartilage-bone 4 and other organs. Analyzing cartilage shifting in relation to the skull bone, we observed a concentric migration pattern.…”

“…One interesting aspect was the GRF pattern change in 12 weeks, with a considerable increase in the number of detached cartilage (from 1/5 in 2 to 6 weeks to 4/5 in 12 weeks), and even then not worse than cyanoacrylate. Ferrigno (2003) 17 observed GRF adhesiveness for 30 days in rabbit venoraphe, but we still lack longer studies. The number of deformed cartilage was directly proportional to the number detached ones (no suture-fixed cartilage was deformed).…”

“…posing a formaldehyde-caused irritation 5,12,17 . Apparently, suturing caused the greater reaction (around the wire) and cyanoacrylate the least (without statistical significance).…”