Estudo histológico e computadorizado das áreas com células parietais e principais no estômago de ratos Wistar tratados com pantoprazol e "N-Nitroso-N-Methylurea"(NMU)

Souza, Iure Kalinine Ferraz de; Silva, Alcino Lázaro da; Misumi, Atsunobu; Savi, Daniela; Custódio, Denílson Santos; Maia, Frederico Fernandes Ribeiro; Canela, Giovanne Guilherme Coutinho; Oliveira, Carlos Henrique Cardoso de

doi:10.1590/s0102-86502002000400009

Cited by 2 publications

(7 citation statements)

References 12 publications

(16 reference statements)

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“…Twelve articles were selected from clinical (9) and experimental (3) studies, for qualitative analysis of the results. Souza et al (2002) studied, for 15 weeks, 40 male Wistar rats divided into four groups: G1 (control), G2 (N-Nitroso-N-Methylurea + pantoprazole ®), G3 (pantoprazole ®) and G4 (N-Nitroso-N-Methylurea). Pantoprazole ® was administered 2x/week (14 mg/ kg body weight, intraperitoneal injection) and NMU offered ad libitum, diluted in drinking water (100 μg/ ml).…”

Section: Methodsmentioning

confidence: 99%

“…In the Hp negative patients there was no alteration on the oxyntic exocrine mucosa. Chronic gastritis/metaplasia atrophy Souza et al (2002), studying the effects of a prolonged use of pantoprazol®, demonstrated a significant reduction in the area of the oxyntic gastric mucosa (with both main and parietal cells), and significant growth of the non-oxyntic gastric mucosa area in the stomach of Wistar rats. Bardhan et al (2005) showed that chronic gastritis decreased in the pylorus region and increased in the body, which also presented atrophic variations.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Clinical and experimental studies suggested that these alterations are related to the development of gastric tumors. 19,21,29 .…”

Section: Introductionmentioning

confidence: 99%

“…The main bacteria involved would be Escherichia coli and Pseudomonas, which proliferation would be stimulated by the state of prolonged hypochloridria. Furthermore, these nitrous compounds and their metabolites are inhibited by vitamin C and other antioxidants agents that protect the DNA 4,21,23,27,29 . According to Muller et al (2007) the chronic atrophic gastritis, a potential late state of gastric infection by Helicobacter pylori (Hp), raises the risk of gastric cancer development up to six times 24 .…”

Section: Introductionmentioning

confidence: 99%

“…Recently some clinical studies have related the prolonged use of PPI with the progressive worsening of gastritis in patients infected by Hp. 10,19,26,29 . The aim of this study is to present a qualitative analysis of the anatomopathological changes in the gastric mucosa resulting from the long-term use of PPI, highlighting the important controversy that still exists on this subject.…”

Section: Introductionmentioning

confidence: 99%

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Análise qualitativa das alterações anatomopatológicas na mucosa gástrica decorrentes da terapêutica prolongada com inibidores da bomba de prótons: estudos experimentais x estudos clínicos

Souza

Silva

Araújo

et al. 2013

ABCD, arq. bras. cir. dig.

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-Introduction: For a few decades the long-term use of proton pump inhibitors has had wide application in the treatment of several gastrointestinal diseases. Since then, however, several studies have called attention to the possible development of anatomical and pathological changes of gastric mucosa, resulting from the long term use of this therapeutic modality. Recent experimental and clinical studies suggest that these changes have connection not only to the development of precancerous lesions, but also of gastric tumors. Objective: To present a qualitative analysis of anatomical and pathological changes of gastric mucosa resulting from the long-term use of proton pump inhibitors. Method: The headings used were: proton pump inhibitors, precancerous lesions and gastric neoplasms for a non systematic review of the literature, based on Medline, Lillacs and Scielo. Twelve articles were selected from clinical (9) and experimental (3) studies, for qualitative analysis of the results. Results: The gastric acid suppression by high doses of proton pump inhibitors induces hypergastrinemia and the consequent emergence of neuroendocrine tumors in animal models. Morphological changes most often found in these experimental studies were: enterochromaffin-like cell hyperplasia, neuroendocrine tumor, atrophy, metaplasia and adenocarcinoma. In the studies in humans, however, despite enterochromaffin-like cell hyperplasia, the other effects, neuroendocrine tumor and gastric atrophy, gastric metaplasia and or adenocarcinoma, were not identified. Conclusion: Although it is not possible to say that the long-term treatment with proton pump inhibitors induces the appearance or accelerates the development of gastric cancer in humans, several authors have suggested that prolonged administration of this drug could provoke the development of gastric cancer. Thus, the evidence demonstrated in the animal model as well as the large number of patients who do or will do a long-term treatment with proton pump inhibitors, justifies the maintenance of this important line of research. RESUMO -Introdução:Há algumas décadas o uso prolongado de inibidores de bomba de prótons tem tido ampla aplicação no tratamento de doenças gastrointestinais. Desde então, entretanto, vários estudos têm alertado para o possível desenvolvimento de alterações anatomopatológicas da mucosa gástrica, decorrentes do uso prolongado desta modalidade terapêutica. Estudos clínicos e experimentais recentes sugerem que estas alterações teriam relação com o desenvolvimento não só de lesões pré-neoplásicas mas, também, de tumores gástricos. Objetivo: Apresentar uma análise qualitativa das alterações antomopatológicas da mucosa gástrica decorrentes do uso prolongado dos inibidores da bomba de prótons. Métodos -Foram utilizados os descritores inibidores da bomba de prótons, lesões pré-neoplásicas e neoplasias gástricas para revisão não sistemática narrativa da literatura, com base nas plataformas Medline, Lillacs e Scielo. Foram selecionados 12 artigos, dentre estudos clíni...

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Section: Methodsmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

“…Clinical and experimental studies suggested that these alterations are related to the development of gastric tumors. 19,21,29 .…”

Section: Introductionmentioning

confidence: 99%