Comparação das anastomoses esôfago-gástricas término-terminais em plano único e por invaginação de submucosa e mucosa, em ratos

JÚNIOR, D IANDOLI; NIGRO, AJT; JULIANO, Y; NOVO, NF; SEMENTILLI, A

doi:10.1590/s0102-86502000000500015

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“…Some authors confirmed a correspondence of 30 days of the man's life to one day of life of the Wistar rat [15][16][17][18] . Therefore, the gastrectomized rat is an excellent experimental model for studies of the metabolism of iron, as only 2 (two) months after the surgery were enough to modify statistically the haematocrit and the haemoglobin among the groups, being smaller in the animals of the GXT group 4,5,6,19,20 .…”

Section: Resultsmentioning

confidence: 72%

Effects of the partial gastrectomy associated to anterior truncal vagotomy in the metabolism of the iron in rats

et al. 2008

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Purpose:To evaluate the effects of the partial gastrectomy associated to anterior truncal vagotomy in the absorption and metabolism of iron. Methods: Eighteen adults male Wistar rats were submitted to the partial gastrectomy associated to anterior truncal vagotomy (eight animals) and the sham operation (10 animals, control group). The diet consumption and the weight gains of the animals were monitored three times during the week. The animals received supplements of vitamin B12, for the prevention of the megaloblastic anemia, and a formulated experimental diet orally and denominated AIN-93M by 8 weeks. The fecal iron, apparent absorption of the iron, haematocrit, haemoglobin and serum iron were measured after 60 days. Results: The animals undergoing sham operation presented larger statistical averages (p<0.05) for the diet consumption, weight gains, apparent absorption of iron, haematocrit, haemoglobin and serum iron compared to the gastrectomized group. However, the excretion of iron in feces was larger in the gastrectomized group (+14.3%) (p<0.05) when compared to the control group. Conclusion: Partial gastrectomy associated to anterior truncal vagotomy showed to be a good experimental model the study of iron metabolism, decreasing the haematocrit, the haemoglobin and the iron absorption, consequently causing anemia. Key words: Gastrectomy. Iron. Anemia. Rats, Wistar. RESUMO Objetivo: Avaliar os efeitos da gastrectomia parcial associada a vagotomia troncular anterior na absorção e metabolismo do ferro. Métodos: Dezoito ratos Wistar machos e adultos foram submetidos a gastrectomia parcial e vagotomia troncular anterior (oito animais) e à laparotomia simples como grupo controle (10 animais). O consumo de dieta e o peso dos animais foram monitorados três vezes por semana. Os animais receberam suplementos de vitamina B12 para prevenção de anemia megaloblástica, além de dieta oral formulada experimentalmente e denominada AIN-93M, durante 8 semanas. O ferro fecal, a absorção aparente de ferro, o hematócrito a hemoglobina e o ferro sérico foram mensurados, após 60 dias de observação. Resultados: Os animais controles apresentaram médias estatísticas maiores (p <0.05) para o consumo de dieta, ganho de peso, absorção aparente de ferro, hematócrito, hemoglobina e ferro sérico comparados aos animais gastrectomizados. Entretanto, a excreção de ferro nas fezes foi superior no grupo de animais gastrectomizados (+14.3%) (p<0.05) quando comparado com o grupo controle. Conclusão: A gastrectomia parcial associada a vagotomia troncular anterior mostrou ser um bom modelo experimental para o estudo do metabolismo do ferro, ocasionando diminuição do hematócrito, da hemoglobina e absorção de ferro, e conseqüentemente causando anemia.

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