Diferenças histomorfométricas entre as artérias torácicas internas esquerda e direita em humanos

Ribeiro, Maria Flavia de Lima; Kneubil, Maximiliano Cassilha; Aquino, Marcello Simão de; Gomes, Guiomar Nascimento; Mazzilli, Paulo; Buffolo, Ênio; Benatti, Camille D.; Gomes, Walter J.

doi:10.1590/s0102-76382008000100002

Cited by 7 publications

(2 citation statements)

References 23 publications

(32 reference statements)

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“…In this study, Verhoeff stain revealed that the ITA is an elastic artery, though anatomically, it is considered to be medium‐sized. Similar results have been reported by others 9,10,21,22. The ITA is considered as an elastic artery in the proximal and middle part, whereas only the distal part is considered as muscular artery.…”

Section: Discussionsupporting

confidence: 86%

Histomorphometric and sympathetic innervation of the human internal thoracic artery

Reddy

Kumar

Prasad

2011

Clinics

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INTRODUCTION:Internal thoracic artery (ITA) is an established arterial graft for the coronary artery by‐pass surgery. Special micro‐anatomical features of the ITA wall may protect it from age related pathological changes. One of the complications seen after coronary artery bypass grafting is vasospasm. Sympathetic nerves may be involved in vasospasm.OBJECTIVE:To ascertain the sympathetic innervation of the internal thoracic artery and to assess the effect of aging on this artery by histomorphometry.METHOD:Fifty‐four human internal thoracic artery samples were collected from 27 cadavers (19 male and 8 female) with ages of 19 to 83 years. Samples were divided into three age groups: G1, 19–40 years; G2, 41–60 years; G3, ≥61 years. Sections (thickness 5 µm) of each sample were taken and stained with hematoxylin–eosin and Verhoeff–Van Gieson stains. Five of fifty‐four samples were processed for tyrosine hydroxylase immunostaining.RESULTS:The thickness of the tunica intima was found to be constant in all age groups, whereas the thickness of the tunica media decreased in proportion to age. Verhoeff–Van Gieson staining showed numerous elastic laminae in the tunica media. Significant differences (p<0.0001) in the number of elastic laminae were found between G1 with G2 cadavers, between G2 and G3 cadavers and between G3 and G1 cadavers. Tyrosine hydroxylase immunostaining demonstrated sympathetic fibers, located mainly in the tunica adventitia and the adventitia–media border. The sympathetic nerve fiber area and sympathetic index were found to be 0.0016 mm2 and 0.012, respectively.DISCUSSION:Histology of the ITA showed features of the elastic artery. This may be associated with lower incidence of Atherosclerosis or intimal hyperplasia in ITA samples even in elderly cases. Low sympathetic index (0.012) of ITA may be associated with fewer incidences of sympathetic nervous systems problems (vasospasm) of the ITA.CONCLUSION:Sympathetic nerve fibers are present in the adventitia of the internal thoracic artery. This is an elastic artery, although anatomically it is considered to be medium‐sized. The sympathetic index may be used for analysis of sympathetic nerve fiber‐related problems of the internal thoracic artery.

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Section: Discussionsupporting

confidence: 86%

Histomorphometric and sympathetic innervation of the human internal thoracic artery

Reddy

Kumar

Prasad

2011

Clinics

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“…Study presented by Ribeiro et al. [ 24 ] shows very little difference from the histological point of view between left and right internal thoracic arteries. noting only that the distal segment of the elastic layer is more prominent.…”

Section: Discussionmentioning

confidence: 91%

Analysis of transit time flow of the right internal thoracic artery anastomosed to the left anterior descending artery compared to the left internal thoracic artery.

Milani¹,

Moraes²,

Sanches³

et al. 2014

Revista Brasileira De Cirurgia Cardiovascular

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IntroductionWe evaluated with transit time flow the performance of the right and left thoracic arteries when used as a graft for the left anterior descending artery.MethodsFifty patients undergoing surgery for myocardial revascularization without cardiopulmonary bypass were divided into two groups. In group A patients received graft of right internal mammary artery to the anterior interventricular branch. In group B patients received graft of left internal mammary artery to the same branch. At the end of the operation the flow was assessed by measuring transit time.ResultsIn group A, mean age was 60.6±9.49 years. The average height and weight of the group was 80.4±10.32 kg and 169.2±6.86 cm. The average number of grafts per patient in this group was 3.28±1.49. The mean flow and distal resistance obtained in right internal thoracic artery was 42.1±23.4 ml/min and 2.8±0.9 respectively. In group B, the mean age was 59.8±9.7 years. The average height and weight of this group was 77.7±14.22 kg and 166.0±8.2 cm. The average number of grafts per patient in this group was 3.08 ±0.82. The mean flow and distal resistance observed in this group was 34.2±19.1 ml/min and 2.0±0.7. There were no deaths in this series.ConclusionRight internal mammary artery presented a similar behavior to left internal mammary artery when anastomosed to the anterior interventricular branch of the left coronary artery. There was no statistical difference between the measured flow obtained between both arteries.

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Blood flow characteristics of the bilateral internal thoracic artery: implications of optimal graft configuration for coronary artery bypass grafting to maximize blood supply

Kunihara

Shingu

Wakasa

et al. 2023

Gen Thorac Cardiovasc Surg

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Diferenças histomorfométricas entre as artérias torácicas internas esquerda e direita em humanos

Abstract: Data analyses from this study suggest structural differences between the left and right internal thoracic arteries.

Cited by 7 publications

References 23 publications

Histomorphometric and sympathetic innervation of the human internal thoracic artery

Histomorphometric and sympathetic innervation of the human internal thoracic artery

Analysis of transit time flow of the right internal thoracic artery anastomosed to the left anterior descending artery compared to the left internal thoracic artery.

Blood flow characteristics of the bilateral internal thoracic artery: implications of optimal graft configuration for coronary artery bypass grafting to maximize blood supply

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