Nefrotoxicidade dos aminoglicosídeos

Oliveira, João Fernando Picollo; Cipullo, José Paulo; Burdmann, Emmanuel A.

doi:10.1590/s0102-76382006000400015

Cited by 52 publications

(27 citation statements)

References 57 publications

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“…Cell death occurs due to drug interference with protein synthesis and misreading of messenger RNA, which leads to changes in membrane function, causing the release of constituents essential for cell viability. 57 In the drug-modifying assays with amikacin ( Figure 2), there was an interaction of OEOg and Eugenol with the antibiotic, resulting in synergism in both S. aureus and E. coli. That is, when amikacin was combined with the test substances, there was an statistically significant increase in the inhibition halo.…”

Section: Resultsmentioning

confidence: 99%

Chemical Profile of Essential oil of Ocimum gratissimum L. and Evaluation of Antibacterial and Drug Resistance-modifying Activity by Gaseous Contact Method

Silva¹,

Carvalho²,

Matias³

2015

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Introduction: Plant products with antimicrobial potential and ability to modulate the action of drugs have become the target of several studies. Many studies of the species Ocimum gratissimum Lamiaceae have reportedbiological activities in the essential oil and extracts of various parts of the plant. Objective: Evaluate the antibacterial and resistance-modifying activity of the essential oil of O. gratissimum (OEOg) and its major compound, Eugenol. Materials and Methods: OEOg was extracted by hydrodistillation and Eugenol was obtained commercially. Multiresistant strains of Escherichia coli and Staphylococos aureus were used to test for drug activity. Antibacterial and resistance-modifying activity of OEOg and Eugenol was evaluated by gaseous contact. Results: Chemical analysis of OEOg demonstrated the presence of Eugenol and other compounds such as 1, 8-cineole and β-selinene as well. In the evaluation of the antibacterial activity, both OEOg and Eugenol were unable to form a bacterial growth inhibition zone at any of the concentrations tested. However, the modulation tests with amikacin and erythromycin identified synergism with OEOg and eugenol against E. coli and S. aureus. Gentamicin combined with OEOg showed antagonism against S. aureus but synergism against E.coli. When gentamicin was combined with Eugenol, there was also synergism against S. aureus, whereas no effect was seen against E. coli. Conclusion: Given the results obtained in this study, it is concluded that OEOg and Eugenol may eventually represent a new therapeutic tool against antibiotic-resistant bacteria.

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Section: Resultsmentioning

confidence: 99%

Chemical Profile of Essential oil of Ocimum gratissimum L. and Evaluation of Antibacterial and Drug Resistance-modifying Activity by Gaseous Contact Method

Silva¹,

Carvalho²,

Matias³

2015

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“…Nephrotoxicity, ototoxicity and neuromuscular blockade are the most important toxic effects of aminoglycosides (Oliveira, 2006;Vallejo et al, 2001). The adverse effects of clindamycin consist mainly of gastrointestinal disorders that can manifest as severe diarrhea and pseudomembranous colitis (Katzung, 2005).…”

Section: Metabolitesmentioning

confidence: 99%

Chemical composition and evaluation of modulatory of the antibiotic activity from extract and essential oil of Myracrodruon urundeuva

Figueredo¹,

Lucena²,

Tintino³

et al. 2013

Pharmaceutical Biology

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Context: The combination of antibiotics with natural products has demonstrated promising synergistic effects in several therapeutic studies. Objective: The aim of this study was to determine the effect of a combination of an ethanol extract of Myracrodruon urundeuva Fr. All. (Anacardiaceae) (aroeira plant) and its essential oil with six antimicrobial drugs against multiresistant strains of Staphylococcus aureus and Escherichia coli from clinical isolates. Materials and methods: After identification of the chemical components by GC-MS, the antibacterial activity of the natural products and antibiotics was assessed by determining the minimal inhibitory concentration (MIC) using the microdilution method and concentrations ranging 8-512 mg/mL and 0.0012-2.5 mg/mL, respectively. Assays were performed to test for a possible synergistic action between the plant products and the antimicrobials, using the extract and the oil at a sub-inhibitory concentration (128 mg/mL) and antibiotic at concentrations varying between 8 and 512 mg/mL. Results: The GC-MS analysis identified the main compound as d-carene (80.41%). The MIC of the natural products was 41024 mg/mL, except against S. aureus ATCC25923. Only the combinations of the natural products with gentamicin, amikacin and clindamycin were effective against S. aureus 358, enhancing the antibiotic activity by reducing the MIC. Conclusions: The extract from aroeira showed a higher antibacterial activity and the oil was more effective in potentiating the activity of conventional antibiotics.

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“…In contrast, the strain was sensitive to the antibiotic nitrofurantoin [28,32]. It seems interesting that the strain is sensitive to the drug present in use since 1952 (Nitrofurantoin) [33] while it shows resistance to the above-mentioned antibiotics later introduced into medical use (Table 3).…”

Section: Quality and Antibiotic Resistance Of Bacterial Aerosol (Ba) mentioning

confidence: 99%

“…However, unlike many of these organisms, it cannot reduce nitrate [34]. Neomycin [33] 1952 Erythromycin [35] 1952 Nitrofurantoin [36] 1956…”

Section: Quality and Antibiotic Resistance Of Bacterial Aerosol (Ba) mentioning

confidence: 99%

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Microbiological Air Quality and Drug Resistance in Airborne Bacteria Isolated from a Waste Sorting Plant Located in Poland―A Case Study

2020

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International interests in biological air pollutants have increased rapidly to broaden the pool of knowledge on their identification and health impacts (e.g., infectious, respiratory diseases and allergies). Antibiotic resistance and its wider implications present us with a growing healthcare crisis, and an increased understanding of antibiotic-resistant bacteria populations should enable better interpretation of bioaerosol exposure found in the air. Waste sorting plant (WSP) activities are a source of occupational bacterial exposures that are associated with many health disorders. The objectives of this study were (a) to assess bacterial air quality (BAQ) in two cabins of a WSP: preliminary manual sorting cabin (PSP) and purification manual sorting cabin (quality control) (QCSP), (b) determine the particle size distribution (PSD) of bacterial aerosol (BA) in PSP, QCSP, and in the outdoor air (OUT), and (c) determine the antibiotic resistance of isolated strains of bacteria. Bacterial strains were identified on a Biolog GEN III (Biolog, Hayward, CA, USA), and disc diffusion method for antimicrobial susceptibility testing was carried out according to the Kirby–Bauer Disk Diffusion Susceptibility Test Protocol. A large share of fecal bacteria, Enterococcus faecalis and Alcaligenes faecalis spp. feacalis, was found in the tested indoor air, which is a potential health hazard to the workers of the monitored WSP. Our results demonstrate the necessity to take into account fecal air pollution levels to avoid making erroneous assumptions regarding the environmental selection of antibiotic resistance. Total elimination of many anthropogenic sources is not possible, but important findings of this study can be used to develop realistic management policies methods to improve BAQ.

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Nefrotoxicidade dos aminoglicosídeos

Cited by 52 publications

References 57 publications

Chemical Profile of Essential oil of Ocimum gratissimum L. and Evaluation of Antibacterial and Drug Resistance-modifying Activity by Gaseous Contact Method

Chemical Profile of Essential oil of Ocimum gratissimum L. and Evaluation of Antibacterial and Drug Resistance-modifying Activity by Gaseous Contact Method

Chemical composition and evaluation of modulatory of the antibiotic activity from extract and essential oil of Myracrodruon urundeuva

Microbiological Air Quality and Drug Resistance in Airborne Bacteria Isolated from a Waste Sorting Plant Located in Poland―A Case Study

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