Efeito do azul de metileno na resposta inflamatória e hemodinâmica em pacientes submetidos à cirurgia de revascularização miocárdica com circulação extracorpórea

Ribeiro, Nilzo; Stolf, Noedir Antônio Groppo; Silva, Augusto; Viana, Valcellos José da Cruz; Carvalho, Eduardo Novaes de; Athanazio, Rodrigo Abensur; Reis, Mitermayer Galvão dos; Oliveira, Sérgio Almeida de

doi:10.1590/s0102-76382004000100005

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Among the 60 papers that appear in the bibliography of this text, through a laborious and error subjected evaluation, the existence of varied types of publications is evidenced: 1) a first series (1.67%) of six non-randomized patients [5]; 2) a series (1.67%) of 60 patients submitted the CPB and randomized to study the inflammatory reaction [12]; 3) a series (1.67%) of 54 non-randomized patients [6,7]; 4) a series (1.67%) of 56 randomized patients in which 28 had received MB to treat VS in cardiac surgery´s postoperative [8][9][10] and; 5) a series (1.67%) of 100 patients with VS risk factors that had been randomized and 50 patients that received MB before the CPB [11]. Observing the other 55 studies we can find: 1) one study (1.67%) based on evidences through metanalysis of literature [13]; 2) seven review articles (11.67%) [4,14,23].…”

Section: Resultsmentioning

confidence: 99%

Methylene blue for vasoplegic syndrome treatment in heart surgery: fifteen years of questions, answers, doubts and certainties

Évora¹,

Ribeiro

Vicente³

et al. 2009

Rev Bras Cir Cardiovasc

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Azul de metileno no tratamento da síndrome vasoplégica em cirurgia cardíaca. Quinze anos de perguntas, respostas, dúvidas e certezasMethylene blue for vasoplegic syndrome treatment in heart surgery. Fifteen years of questions, answers, doubts and certainties AbstractObjective: There is strong evidence that methylene blue (MB), an inhibitor of guanylate cyclase, is an excellent therapeutic option for vasoplegic syndrome (VS) treatment in heart surgery. The aim of this article is to review the MB's therapeutic function in the vasoplegic syndrome treatment.Methods: Fifteen years of literature review.Results: 1) Heparin and ACE inhibitors are risk factors; 2) In the recommended doses it is safe (the lethal dose is 40 mg/ kg); 3) The use of MB does not cause endothelial dysfunction; 4) The MB effect appears in cases of nitric oxide (NO) upregulation; 5) MB is not a vasoconstrictor, by blocking of the GMPc system it releases the AMPc system, facilitating the norepinephrine vasoconstrictor effect; 6) The most used dosage is 2 mg/kg as IV bolus followed by the same continuous infusion because plasmatic concentrations strongly decays in the first 40 minutes; 7) There is a possible "window of opportunity" for the MB's effectiveness.Conclusions: Although there are no definitive multicentric studies, the MB used to treat heart surgery VS, at the present time, is the best, safest and cheapest option, being a Brazilian contribution for the heart surgery.

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Section: Resultsmentioning

confidence: 99%

Methylene blue for vasoplegic syndrome treatment in heart surgery: fifteen years of questions, answers, doubts and certainties

Évora¹,

Ribeiro

Vicente³

et al. 2009

Rev Bras Cir Cardiovasc

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“…Ohri et al [16] have shown that changes in thyroid hormone levels are likely to detect the immediate postoperative period, since at this stage, there is an active state of catabolism associated with high rates of oxygen consumption [17][18][19][20]. Some authors have postulated that the decrease in thyroid hormones in the post-CPB favors the occurrence of global myocardial dysfunction and arrhythmias, especially atrial fibrillation [21][22][23][24][25].…”

Section: Fig 3 -Comparison Between Two Moments For Total T3 Free T3mentioning

confidence: 99%

Revascularização miocárdica com circulação extracorpórea; aspectos bioquímicos, hormonais e celulares

Gabriel¹,

Locali²,

Matsuoka³

et al. 2011

Rev Bras Cir Cardiovasc

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Revascularização miocárdica com circulação extracorpórea; aspectos bioquímicos, hormonais e celularesOn-pump coronary artery bypass graft surgery: biochemical, hormonal and cellular features This study was carried out at Federal University of São Paulo, Discipline of Cardiovascular Surgery, São Paulo, SP, Brazil. Methods: Eighteen patients underwent on-pump CABG surgery. Mean time of CPB was 80.3 minutes. Hormonal, biochemical and cellular measurements were taken in some time points -preoperatively, immediately after coming off CPB, 24 and 48 hours postoperatively. Friedman and Wilcoxon tests were applied based on significance level of 5%.Results: There was activation and significant elevation of total leukocytes and neutrophils count over CPB, remaining this way up to 48 hours postoperatively. Total platelets count, in turn, was marked by relevant reduction immediately after coming off CPB as well as in two postoperative time points. Serum levels of total proteins and albumin, immediately after coming off CPB and also in two postoperative time points, were significantly decreased comparing with preoperative status. There was remarkable reduction of total T3, free T3 and total T4 particularly up to first 24 hours postoperatively.Conclusion: In on-pump CABG surgery, inflammatory effects encompass activation of total leukocytes, neutrophils and platelets, reduction of serum level of total proteins and albumin and decreased thyroid hormones levels, especially within first postoperative 24 hours.

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Effect of On-Pump CABG (Roller Versus Centrifugal Systems) on MCP-1, TNFsR and IL6 Behaviour

Braulio¹,

Sanches²,

Teixeira³

et al. 2015

J Cardiovasc Dis Diagn

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Efeito do azul de metileno na resposta inflamatória e hemodinâmica em pacientes submetidos à cirurgia de revascularização miocárdica com circulação extracorpórea

Cited by 3 publications

References 23 publications

Methylene blue for vasoplegic syndrome treatment in heart surgery: fifteen years of questions, answers, doubts and certainties

Methylene blue for vasoplegic syndrome treatment in heart surgery: fifteen years of questions, answers, doubts and certainties

Revascularização miocárdica com circulação extracorpórea; aspectos bioquímicos, hormonais e celulares

Effect of On-Pump CABG (Roller Versus Centrifugal Systems) on MCP-1, TNFsR and IL6 Behaviour

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