Testes in vitro e in vivo com o Coração Artificial Auxiliar (CAA): um novo modelo de coração artificial totalmente implantável e heterotópico

Estudo experimental da aplicação do ventrículo artificial eletromecânico pulsátil implantável

“…cardiac output of 5 L/min against a mean afterload of 100 mm Hg. At a fixed frequency (FF), especially for pre-loading above 2.5 mmHg, the output was not affected, due to the fact that it is necessary low pressure to achieve complete filling of the chamber for adjusted frequencies, it means that when the pre-loaded is higher than 2.5 mmHg and frequency between 80 to 130 bpm, the device operates completely filled [9] (Figure 7). Tables 1 and 2, in which whether the EC was used or not the device implantation, survival and the causes behind the occurrence In experiments that showed increased survival (7 to 31 days) the following laboratory data were determined: hemoglobin, hematocrit, leukocytes, platelets, glucose, fibrinogen, urea, creatinine, AST, Gamma GT, TCA (1st PO period), TCA, PT and INR, with the aim to analyze its traumatic impact to the blood crasis.…”

“…Given this reality, the Division of Bioengineering, in association with the Division of Cardiovascular Surgery at Dante Pazzanese Institute of Cardiology (IDPC) developed a prototype of electromechanical operation and pulsatile flow [8][9][10]. The resulting device is originated from ejection alternating two diaphragms situated in two pumping chambers and its movements performed by brushless motor, controlled by an electronic controller with rechargeable batteries and can be used as an auxiliary to the left ventricle (LV) for both ventricles, even as artificial heart entirely replacing the native organ.…”

Desempenho hemodinâmico e resposta inflamatória durante o uso do DAV-InCor como ponte para o transplante

“…In Brazil, the experience with the use of mechanical circulatory-assist devices in the treatment of cardiogenic shock is small and comprises only isolated case reports 12,13 or experiments related to the development of new devices [14][15][16] . In parallel, the life expectancy of the patients in this situation, particularly those of Chagasic etiology, is very limited 17 , requiring the implementation of regular programs of mechanical circulatory assistance, especially as a bridge to cardiac transplantation.…”

Sistema de controle para diagnóstico e tratamento de falhas em dispositivos de assistência ventricular.

“…Mesmo com a utilização de um DAV, o coração natural permanece em funcionamento, minimizando assim, consequentes problemas com o balanceamento e controle fisiológico das pressões e fluxos sanguíneos (ANDRADE et al, 1999;NOSÉ;OKUBO, 2003).…”

“…Thus, is possible to achieve an autonomous and safe control system that complies with the applicable technical standards, as well as the strict project requirements for this class of system. CONSIDERANDO Conflitos ......................................... 126 5.3.3 Validação dos modelos em rede de Petri obtidos ............................................................. 128 5.4 Cardiovascular e DAV adotado .......................................... 130 5.5 (GHISTA et al, 1972;SMEDIRA, 2005;ANDRADE et al, 1999;COOLEY, 2011).…”