“…The TOR inhibitors: Tacrolimus (also known as FK-506 or Fujimycin) has a similar action to cyclosporine and is used as a second option to cyclosporine, and Sirolimus, also known as rapamycin, has an inhibitory effect on activation and proliferation of T cells. So, these immunosupressive drugs reduce the infection risk, but may have some undesirable adverse effects (Bortolotto, 1997;Fiorelli, 1996), such as nephrotoxic effects, artery damage and narrowing, left ventricle hypertrophy, increased likelihood of bone fractures and infections. These entire side effects contribute to related health problems over time, so it makes professional responsible for their physical rehabilitation more attempted to effects during exercise as increased blood pressure, transient ischemic attack (TIA).…”