Anticonvulsant and antioxidant activity of aqueous leaves extract of Desmodium triflorum in mice against pentylenetetrazole and maximal electroshock induced convulsion

Bhosle, Vaibhav

doi:10.1590/s0102-695x2013005000047

Cited by 27 publications

(22 citation statements)

References 19 publications

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“…After half an hour; the tubes were taken out and kept in ice-cold water for half an hour Keep test tube in cold water for half an hour. Then process homogenate was centrifuged at 3000 RPM for 15 min, the supernatant was separated out and absorbance was noted down at 535 nm against blank [21].…”

Section: Estimation Of Lipid Peroxidationmentioning

confidence: 99%

Pharmacological Evaluation of Triphala Churna Instreptozotocin (I. C. V.) Induced Dementia in Rats

Deka¹,

Kumar²

2018

Int J Pharm Pharm Sci

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Objective: The objective of the study was to investigate the memory improving activity of Triphala Churna hydro-methanolic fruit extract on learning and memory functions in Streptozotocin (I. C. V) induced dementia in rats by using morris water maze and elevated plus maze.Methods: A total of 42 albino wistar rats weighing 80-100 g were randomized into 7 equal groups as follows: Normal control group received normal saline (1 ml/kg p. o.) for 24 d, STZ treated group (3 mg/kg, i. c. v) were administered in two dosage regimen i.e. on first day and third day.), Standard group: Streptozotocin (3 mg/kg i. c. v)+Vitamin E (100 mg/kg/day p. o.) were administered for 21 d, Standard group: Streptozotocin (3 mg/kg i. c. v)+Rivastigmine (2 mg/kg/day p. o.) were administered for 21 d. The learning and memory-impaired rats were treated with Triphala Churna Formulation 1, Triphala Churna Formulation 2 and Triphala Churna Formulation 3 for 21 d (100 mg/kg p. o.). AchE activity, lipid peroxidation, superoxide dismutase, glutathione level of brain homogenate was estimated in Control/STZ (I. C. V)/Standard/Triphala Churna fruits extract treated rats.Results: Administration of Triphala Churna fruits extract significantly restored learning and memory impairment induced by STZ (I. C. V) in the elevated plus maze and morris water maze. Furthermore, in the TPLC F2 and TPLC F3 treated group brain AchE level was decreased (P≤0.01) as well as brain lipid peroxidation was also decreased (P≤0.001). Brain antioxidant enzymes such as glutathione level were increased (P≤0.001) in the TPLC1 and TPLC2 treated group when compared to the STZ treated group, TPLC F2 and TPLC F3 treated group showed significant (P≤0.001, P≤0.01) increase in superoxide dismutase level. Conclusion: Triphala Churna fruits extract has an improving effect on learning and memory impairment rats produced by Streptozotocin (I. C. V) and may have a useful effect in the treatment of dementia and Alzheimer's disease.

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Section: Estimation Of Lipid Peroxidationmentioning

confidence: 99%

Pharmacological Evaluation of Triphala Churna Instreptozotocin (I. C. V.) Induced Dementia in Rats

Deka¹,

Kumar²

2018

Int J Pharm Pharm Sci

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“…In Lombok, the Sasak tribe use D. triflorum leaves to treat wounds and diarrhea. The plant contains alkaloid, flavonoids, saponin, and tannins [63]. β-Phenethylamine, hypaphorine methyl ester (43), hypaphorine (45), trigonelline (46), betaine and choline were found to be the major alkaloids in the leaves and roots of D. triflorum [64].…”

Section: Desmodium Triflorummentioning

confidence: 99%

Leguminous Plants in the Indonesian Archipelago: Traditional Uses and Secondary Metabolites

Bahtiar

Vichitphan

Han

2017

Natural Product Communications

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Indonesia is one of the richest countries with respect to plants resources. People from various ethnic, language, and religious groups have used the plants as alternative medicines, health foods and beverages for hundreds of years. To establish modern application for these understudied plant resources, ethnopharmacological data from more than 40 leguminous plants in Indonesia, spanning the western to the eastern parts of the Indonesian archipelago, were reviewed. In particular, bioactive secondary metabolites, including flavonoids, were described in detail to promote research into these plants as functional foods, nutraceuticals, and medicines.

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“…6 In many patients, the presently available antiepileptic drugs (AED) such as phenobarbital, benzodiazepines, sodium valproate, carbamazepine, ethosuximide, trimethadione etc., are unable to control seizures efficiently and the problem of adverse effects has also not been circumvented completely and approximately 30% of the patients continue to have seizures with current antiepileptic drugs therapy. 7,8 Hence, search should continue to develop newer, more effective, and safer neuroprotective agents for treatment of epilepsy.…”

Section: Epilepsy In Indiamentioning

confidence: 99%

Anticonvulsant effect of nifedipine, dizepam and in combination on pentylenetetrazol induced experimental models of epilepsy on albino rats

Muralidhar

Prasad²,

Sridhar

2017

Int J Basic Clin Pharmacol

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Background: In many patients, the presently available antiepileptic drugs such as phenobarbital, phenytoin, benzodiazepines, sodium valproate, etc., are unable to control seizures efficiently and the problem of adverse effects has also not been circumvented completely and approximately 30% of the patients continue to have seizures with current antiepileptic drugs therapy. Hence, search should continue to develop newer, more effective, and safer neuro-protective agents for treatment of epilepsy. Aim of the study was to investigate the activity of nifedipine, the dihydropyridine calcium channel blocker, diazepam, the benzodiazepine anticonvulsant of established efficacy and their combinations against rat models of pentylenetetrazol (PTZ) induced convulsions. Method: Wister albino rats of either sex, weighing between 150-220gm were used. Rats were divided into 10 groups, in each group n=6 total N=60. Methods: PTZ was administration 30 min after test drug administration. Intraperitoneal injection of PTZ at the dose of 80mg/Kg body weight were administered to the rats to produce chemically-induced seizure. The effect of nifedipine and diazepam were assessed on such seizure model. The onset and duration of clonic convulsion were recorded. Results: The onset time of PTZ-induced clonic convulsion was significantly prolonged with the Nifedipine in the doses of 4mg and 8mg per Kg. in comparison to nifedipine in dose of 2mg per Kg. The interesting observation was that while Diazepam in 1mg/Kg. dose significantly (P<0.05) prolonged the onset time, there was significant decrease (P <0.001) in the onset time of PTZ-induced clonic convulsion with diazepam in doses of 2 and 4mg per Kg. in comparison to Diazepam 1mg per Kg. But the combination of diazepam 2.5 mg and Nifedipine 2.6mg and 5.3mg exhibited significant prolongation of the onset time. Diazepam 1 and 2mg per Kg was found to be equally effective in reduction of convulsion time, while 4mg dose showed more reduction of convulsion time. The combination of diazepam and nifedipine showed no better reduction in the convulsion time and also valproic acid in doses of 135mg. Kg. Conclusions: Nifedipine (3-5mg/Kg) and diazepam (2.5mg/Kg.) combination delayed the onset of convulsion. Diazepam 2mg / Kg. alone was effective in reduction of duration of convulsion. The combination dose having 2.6mg of nifedipine showed comparable protection with valproic acid 135mg per Kg. while the combination having 5.3mg of nifedipine showed significantly better protection.

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Anticonvulsant and antioxidant activity of aqueous leaves extract of Desmodium triflorum in mice against pentylenetetrazole and maximal electroshock induced convulsion

Cited by 27 publications

References 19 publications

Pharmacological Evaluation of Triphala Churna Instreptozotocin (I. C. V.) Induced Dementia in Rats

Pharmacological Evaluation of Triphala Churna Instreptozotocin (I. C. V.) Induced Dementia in Rats

Leguminous Plants in the Indonesian Archipelago: Traditional Uses and Secondary Metabolites

Anticonvulsant effect of nifedipine, dizepam and in combination on pentylenetetrazol induced experimental models of epilepsy on albino rats

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