Copaifera multijuga ethanolic extracts, oilresin, and its derivatives display larvicidal activity against Anopheles darlingi and Aedes aegypti (Diptera: Culicidae)

Trindade, Frances Tatiane Tavares; Stábeli, Rodrigo G.; Pereira, Antônio Almeida; Facundo, Valdir Alves; Silva, Alexandre de Almeida e

doi:10.1590/s0102-695x2013005000038

Cited by 29 publications

(1 citation statement)

References 17 publications

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“…The chemical composition of the copaiba oil (COP) as identified by GC-MS is shown in Table 1. The identification of these compounds was performed by comparison of their mass spectra with those of the Wiley 7 and NIST 08, spectral libraries, as well as by comparison of their retention indexes with those in the literature [12,13,14,15]. A total of 25 compounds were identified, namely twenty-three sesquiterpene hydrocarbons and two sesquiterpene alcohols.…”

Section: Resultsmentioning

confidence: 99%

Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)

et al. 2014

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Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis. We have investigated the immunomodulatory effects of copaiba oil (100, 50 and 25 µg/mL) on NO, H 2 O 2 , TNF-α, IFN-γ and IL-17 production in cultured cells from EAE-mice. Copaiba oil (100 µg/mL) inhibited H 2 O 2 , NO, IFN-γ TNF-α and IL-17 production spontaneously or after ConA and MOG stimulation. It is suggested that copaiba oil acts on the mechanism of development of EAE by IFN-γ, IL-17 and TNF-α inhibition, modulating the immune response on both Th1 and Th17 cells.

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Section: Resultsmentioning

confidence: 99%

Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)

et al. 2014

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Reliable Methods for Analyses of Volatile Compounds of Copaifera Oleoresins Combining Headspace and Gas Chromatography

Silva

Ribeiro

Lemos

et al. 2019

Chemistry & Biodiversity

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Two analytical methods were developed in this study for direct and fast chemical investigation of authentic Copaifera oleoresins (COR) and commercial products. Polydimethylsiloxane microfiber coupled to gas chromatography-mass spectrometry (HS-SPME-GC/MS) showed the best results for oleoresin qualitative analysis, setting the following extraction conditions: equilibrium time of 15 min, extraction time of 30 min, extraction temperature at 60°C and constant stirring of 400 rpm. Sesquiterpenes α-copaene, β-elemene, β-caryophyllene and trans-α-bergamotene were found in all investigated samples. Quantitative analysis by gas chromatography coupled with flame ionization detector (GC-FID) measured the content of the four sesquiterpenes in all samples. Qualitative and quantitative results showed important differences between COR of distinct species and commercial products. Data regarding the volatile composition of C. oblongifolia and C. trapezifolia oleoresins were first presented in this study and two new analytical methods were reported for direct and fast qualitative and quantitative analysis of COR.

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Larvicidal activity of natural and modified triterpenoids against Aedes aegypti (Diptera: Culicidae)

Silva

Trindade

Santos

et al. 2016

Pest Management Science

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Copaifera multijuga ethanolic extracts, oilresin, and its derivatives display larvicidal activity against Anopheles darlingi and Aedes aegypti (Diptera: Culicidae)

Cited by 29 publications

References 17 publications

Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)

Copaiba Oil Suppresses Inflammatory Cytokines in Splenocytes of C57Bl/6 Mice Induced with Experimental Autoimmune Encephalomyelitis (EAE)

Reliable Methods for Analyses of Volatile Compounds of Copaifera Oleoresins Combining Headspace and Gas Chromatography

Larvicidal activity of natural and modified triterpenoids against Aedes aegypti (Diptera: Culicidae)

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