Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents

Barreto, Rosana S.S.; Albuquerque-Junior, Ricardo L. C. de; Pereira-Filho, Rose Nely; Quintans, Jullyana S.S.; Barreto, André S.; DeSantana, Josimari Melo; Filho, Valter Joviniano de Santana; Santos, Márcio Roberto Viana dos; Bonjardim, Leonardo Rigoldi; Araújo, Adriano A. S.; Quintans‐Júnior, Lucindo J.

doi:10.1590/s0102-695x2013005000010

Cited by 22 publications

(20 citation statements)

References 36 publications

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“…In the current studym the quantitative analysis of the immunohistochemical expression of type I collagen, over the time-course of wound healing showed progressive collagenization occurring from three to 21 days, but even at the end of the experimental period, it remained lower in comparison with the non-injured dermal tissues. In accordance with our data, several studies have also reported the same collagenization profile in wound healing experimental models 3,18 . At earlier phases, type I collagen fibers are scanty, thin, delicate and parallel-arranged, but as long as the healing process evolutes, the fibers become gross, thick, and display an interlaced arrangement.…”

Section: Resultssupporting

confidence: 93%

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Immunohistochemical Profile of Stromal Constituents and Lymphoid Cells Over the Course of Wound Healing in Murine Model

Filho

Moda

Nascimento

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Section: Resultssupporting

confidence: 93%

“…Several studies have been performed in order to search for new therapeutic approaches to improve wound healing 3,5 . Such studies have used histochemical and/or immunohistochemical methods to investigate the morphological changes that occur during the healing process of injured dermal tissues.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Profile of Stromal Constituents and Lymphoid Cells Over the Course of Wound Healing in Murine Model

Filho

Moda

Nascimento

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…20 It was found to inhibit leukotriene B4 synthesis in leukocytes, which might affect inflammatory processes 21 and modulates the wound healing process. 22…”

Section: Resultsmentioning

confidence: 99%

A Triterpene and a Depside from Parmotrema austrocetratum Elix and J. Johnst.

Ragasa¹,

Tan²,

Linis³

et al. 2018

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A Triterpene and a Depside from Parmotrema austrocetratum Elix and J. Johnst. ABSTRACT Introduction: Parmotrema austrocetratum Elix and J. Johnst. (syn. Rimelia austrocetrata Elix and J. Johnst.) which belongs to a large genus of lichenized fungi, Parmotrema Massalongo under family Parmeliaceae was investigated for its chemical constituents. Methods: The compounds were isolated by silica gel chromatography and their chemical structures were elucidated by NMR spectroscopy. Results: Chemical investigation of the dichloromethane extract of Parmotrema austrocetratum Elix and J. Johnst. has led to the isolation of zeorin (1) and atranorin (2). Conclusion: P. austrocetratum shares similar chemical characteristic with other Parmotrema species which afforded atranorin. This work highlights the first reported isolation of 1 from P. austrocetratum and the genus Parmotrema. ABSTRACT SUMMARY • Chemical investigation of the dichloromethane extract of P. austrocetratum has led to the isolation of zeorin (1) and atranorin (2). This is the first report on the isolation of 1 from P. austrocetratum and the genus Parmotema.Consolacion Y. Ragasa: Full Professor 10

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“…It has been reported that partial thickness wounds are supposed to heal by mere epithelialization, whereas the healing of full thickness wound involves more complex wellregulated biological events, including the inflammatory response, granulation tissue formation, myofibroblastic differentiation and collagenization 2,3 . This process is directly or indirectly responsible or eliminating the bacterial load, removing necrotic debris, inducing wound contraction and stimulating the scar formation.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical profile of stromal constituents and lymphoid cells over the course of wound healing in murine model

et al. 2014

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Evaluation of wound healing activity of atranorin, a lichen secondary metabolite, on rodents

Cited by 22 publications

References 36 publications

Immunohistochemical Profile of Stromal Constituents and Lymphoid Cells Over the Course of Wound Healing in Murine Model

Immunohistochemical Profile of Stromal Constituents and Lymphoid Cells Over the Course of Wound Healing in Murine Model

A Triterpene and a Depside from Parmotrema austrocetratum Elix and J. Johnst.

Immunohistochemical profile of stromal constituents and lymphoid cells over the course of wound healing in murine model

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