Extracts from the leaves of Campomanesia velutina inhibits production of LPS/INF-γ induced inflammatory mediators in J774A.1 cells and exerts anti-inflammatory and antinociceptive effects in vivo

Michel, Marcela Carolina de Paula; Grabe‐Guimarães, Andrea; Paula, Carmem Aparecida de; Rezende, Simone Aparecida; Sobral, Marcos; Guimarães, Dênia Antunes Saúde

doi:10.1590/s0102-695x2013000600010

Cited by 20 publications

(9 citation statements)

References 22 publications

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“…The present study shows that extracts of C. xanthocarpa exhibit anti-inflammatory properties. Other species of Campomanesia have shown similar results [3][4][5].…”

Section: Discussionmentioning

confidence: 54%

“…Plants of the genus Campomanesia are used in folk medicine against inflammatory diseases and urinary disturbances. Some studies showed the anti-inflammatory properties of extracts of Campomanesia velutina and Campomanesia adamantium leaves [3,4]. The extracts of C. adamantium fruit bark also exhibited antihyperalgesic, antidepressant, and anti-inflammatory effects in experimental models in rodents [5].…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

et al. 2016

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Campomanesia xanthocarpa (Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2',6'-dihydroxy-3'-methyl-4'-metoxychalcone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone were identified for the first time in leaves of the C. xanthocarpa. These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test.

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“…The present study shows that extracts of C. xanthocarpa exhibit anti-inflammatory properties. Other species of Campomanesia have shown similar results [3][4][5].…”

Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

et al. 2016

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“…This is the first report on the anti-TNF- α activity of C. lineatifolia , although other species of Campomanesia have been described to have anti-inflammatory properties, like Campomanesia velutina , whose ethanolic extract from leaves decreased the paw edema induced by carrageenan in mice [37]. In a previous publication, we described the anti-TNF- α activity of Terminalia glabrescens on LPS-stimulated THP-1 cells [8].…”

Section: Resultsmentioning

confidence: 98%

In VitroTNF-αInhibitory Activity of Brazilian Plants and Anti-Inflammatory Effect ofStryphnodendron adstringensin an Acute Arthritis Model

Henriques

Corrêa

Azevedo

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Stryphnodendron species, popularly named “barbatimão,” are traditionally used in Brazil as anti-inflammatory agents. This study aimed to investigate the effect of barbatimão and 11 other species on the production of tumor necrosis factor-alpha (TNF-α) in lipopolysaccharide- (LPS-) stimulated THP-1 cells, as well as their anti-arthritis activity. The extracts of Stryphnodendron adstringens, Stryphnodendron obovatum, Campomanesia lineatifolia, and Terminalia glabrescens promoted a concentration-dependent inhibition of TNF-α. Mice injected with LPS in the knee joint were treated per os with fractions from the selected extracts. Both the organic (SAO) and the aqueous (SAA) fractions of S. adstringens promoted a dose-dependent reduction of leukocyte migration and neutrophil accumulation into the joint, but none of them reduced CXCL1 concentration in the periarticular tissue. In contrast, treatment with C. lineatifolia and T. glabrescens fractions did not ameliorate the inflammatory parameters. Analyses of SAO by Ultra Performance Liquid Chromatography (UPLC) coupled to electrospray ionization mass spectrometry (ESI-MS) led to the identification of gallic acid along with 11 prodelphinidins, characterized as monomers and dimers of the B-type. Our findings contribute to some extent to corroborating the traditional use of S. adstringens as an anti-inflammatory agent. This activity is probably related to a decrease of leukocyte migration into the inflammatory site. Polyphenols like gallic acid and prodelphinidins, identified in the active fraction, may contribute to the observed activity.

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“…The results of the present study demonstrated that C. velutina has anti-inflammatory and antinociceptive. However, the complete mechanisms of these actions remain to be elucidated [15].…”

Section: Introductionmentioning

confidence: 99%

Investigation of Campomanesia Components: A Fruit of Brazilian Cerrado

Lima¹,

Arakaki²,

SaldanhaTschinkel³

et al. 2017

Active Ingredients From Aromatic and Medicinal Plants

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A survey of chemical composition of the fruit of Campomanesia adamantium used by rural and urban inhabitants of the cities of the Campo Grande, Mato Grosso do Sul State, Brazil, was carried out by inductively coupled plasma-optical emission spectroscopy (ICP-OES) aiming at the detection of minerals. Fifteen minerals were detected in the peel, pulp, and seeds of plant. The concentrations of elements K, Ca, Na, and P are found to be present at the major level in peel, pulp, and seeds of fruit. The zinc concentration is very low compared to other detected elements. The levels of some chemical elements in the fruit do not exceed the limits established by international legislation. Animal studies should be performed. The knowledge of the chemical elements in plants has economic interest, and involves global health problem.

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Extracts from the leaves of Campomanesia velutina inhibits production of LPS/INF-γ induced inflammatory mediators in J774A.1 cells and exerts anti-inflammatory and antinociceptive effects in vivo

Cited by 20 publications

References 22 publications

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

In VitroTNF-αInhibitory Activity of Brazilian Plants and Anti-Inflammatory Effect ofStryphnodendron adstringensin an Acute Arthritis Model

Investigation of Campomanesia Components: A Fruit of Brazilian Cerrado

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