Evaluation of antidiabetic antihyperlipidemic and pancreatic regeneration, potential of aerial parts of Clitoria ternatea

Verma, Prashant; Itankar, Prakash R.; Arora, Sumit K.

doi:10.1590/s0102-695x2013000500015

Cited by 51 publications

(45 citation statements)

References 36 publications

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“…This adverse effect may probably be as a result of the high antioxidant capacity in this dose and is in line with reports elsewhere [24, 31], where increase in antioxidant levels above its physiological dose had cytotoxic effect, also consistent with earlier finding [13] which suggested that methanolic leaf extract of V. amygdalina had the potential of adversely affecting haematological indices. The observed significant difference between the negative control and treated rats in some of the enzyme level associated with liver function test (ALT, AST, and ALP) as well as HDL-C, LDL-C, and VLDL-C levels, and this is in agreement with reports from previous research works [26, 32] where STZ was used as the diabetogenic agent. The increase levels in AST, ALT, and ALP in blood serum in this study suggest hepatocellular damage as a result of STZ toxicity.…”

Section: Discussionsupporting

confidence: 92%

Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts ofVernonia amygdalina: A Comparative Study

Asante

Effah-Yeboah

Barnes

et al. 2016

Journal of Diabetes Research

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The young leaves of Vernonia amygdalina are often utilized as vegetable and for medicinal purpose compared to the old leaves. This study was designed to evaluate and compare the antidiabetic effects between ethanolic leaf extracts of old and young V. amygdalina on streptozotocin (STZ) induced diabetic rat for four weeks. Preliminary screening of both young and old ethanolic extracts revealed the presence of the same phytochemicals except flavonoids which was only present in the old V. amygdalina. Difference in antioxidant power between the young and old leaf extracts was statistically significant (p < 0.05). Both leaf extracts produced a significant (p < 0.05) antihyperglycaemic effect. Also results from treated rats revealed increasing effect in some haematological parameters. Similarly, the higher dose (300 mg/kg) of both extracts significantly (p < 0.05) reduced serum ALT, AST, and ALP levels as compared to the diabetic control rats. Results also showed significant (p < 0.05) decrease in LDL-C and VLDL-C in the extract-treated rats with a corresponding increase in HDL-C, as compared to the diabetic control rats. Moreover histopathological analysis revealed ameliorative effect of pathological insults induced by the STZ in the pancreas, liver, and spleen, most significantly the regeneration of the beta cells of the islets of Langerhans in treated rats.

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Section: Discussionsupporting

confidence: 92%

Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts ofVernonia amygdalina: A Comparative Study

Asante

Effah-Yeboah

Barnes

et al. 2016

Journal of Diabetes Research

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“…The higher potential of ETM (500 mg/kg) over others extracts, which contains a polyphenol, triterpenoids, flavonoids and saponins that may result in increased antidiabetic potential (Verma, et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic and antihyperlipidemic activity of Euphorbia thymifolia L. extracts on streptozotocin-nicotinamide induced type 2 diabetic rats

Parmar¹,

Pundarikakshudu²,

Balaraman³

2017

J App Pharm Sci

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The present investigation is aimed to elucidate the hypoglycaemic and hypolipidemic effect of the aqueous and methanol extract of Euphorbia thymifolia (ET) aerial parts in streptozotocin-nicotinamide (STZ-NA) induced diabetic rats. Diabetes was induced by administration of STZ (65 mg/kg, i.p.) followed by NA (110 mg/kg i.p.) 15 min later. The diabetic rats were treated with aqueous and methanol extract from ET (250 and 500 mg/kg, p.o., respectively) for 28 days. Fasting blood glucose level, plasma insulin, HbA1c, urea, serum creatinine, lipid profile, liver glycogen, ALP, total protein and histopathology of pancreas were carried out to assess antidiabetic and antihyperlipidemic effect. After treatment with ET extracts fasting blood glucose, HbA1c levels, urea, serum creatinine and total protein were significantly decrease in diabetic rats. However, serum insulin level and liver glycogen were significantly increased in diabetic rats. The extracts also exhibited a significant hypolipidemic effect as evident from fall in total cholesterol, triglycerides, low-density lipoproteins and increase high-density lipoproteins level. The histopathological studies of the pancreas in extract treated diabetic groups revealed almost normal appearance. This study supports the traditional proclamations on E. thymifolia aerial parts.

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“…In addition to the above-mentioned herbs, a number of others has been found to have potential protective or regenerative properties on beta cells: Abroma augusta (Mir, Darzi, Mir, 2013), Alchornea cordifolia (EliakimIkechukwu, Obri, 2009), Amaranthus caudatus (Girija et al, 2011), Amaranthus spinosus (Girija et al, 2011), Amaranthus viridis (Girija et al, 2011), Artanema sesamoides (Selvan et al, 2008), Bauhinia variegata (Koti et al, 2009), Cassia alata (Eliakim-Ikechukwu et al, 2013, Cassia occidentalis (Verma et al, 2010), Clitoria ternatea (Verma, Itankar, Arora , 2013), Elephantopus scaber (Daisy et al, 2007), Epicatechin (Chakravarthy, Gupta, Gode, 1982), Leucaena leucocephala (DarmonoSyamsudin, Simanjuntak, 2006), Mangiferin (Wang et al, 2014), Morus alba (Mohammadi, Prakash, 2008), Prangos ferulacea (Soltani Band et al, 2011), Pterocarpus marsupium (Chakravarthy et al, 1980), Sansevieria trifasciata (Qomariyah, Sarto, Pratiwi, 2012), Syzygium cumini (Singh, Gupta, 2007a), Teucrium polium (Yazdanparast, Esmaeili, Ashrafi, 2005), Thunbergia laurifolia (Aritajat, Wuteerapol, Saenphet,, 2004), Tinospora cordifolia (Rajalakshmi et al, 2009), Trigonella foenum-graceum (Kulkarni et al, 2012), Vinca rosea (Ahmed et al, 2010), Urtica dioica (Golalipour et al, 2010), and Urtica pilulifera (Kavalali et al, 2003). However, for each one, only one study from independent authors was found to support their protective or regenerative effects on beta cells.…”

Section: Other Plants With Protective Effects On Pancreasmentioning

confidence: 99%

Pancreatic beta cell protection/regeneration with phytotherapy

Hosseini

Shafiee-Nick

Ghorbani

2015

Braz. J. Pharm. Sci.

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Although currently available drugs are useful in controlling early onset complications of diabetes, serious late onset complications appear in a large number of patients. Considering the physiopathology of diabetes, preventing beta cell degeneration and stimulating the endogenous regeneration of islets will be essential approaches for the treatment of insulin-dependent diabetes mellitus. The current review focused on phytochemicals, the antidiabetic effect of which has been proved by pancreatic beta cell protection/regeneration. Among the hundreds of plants that have been investigated for diabetes, a small fraction has shown the regenerative property and was described in this paper. Processes of pancreatic beta cell degeneration and regeneration were described. Also, the proposed mechanisms for the protective/ regenerative effects of such phytochemicals and their potential side effects were discussed. Embora medicamentos disponíveis atualmente sejam úteis no controle de complicações da Diabetes, complicações aparecem em grande número de pacientes. Considerando-se a fisiopatologia do Diabetes, a prevenção da degeneração de células beta e o estímulo da regeneração endógena de ilhotas será abordagem essencial para o tratamento de diabetes mellitus insulino-dependente. A presente revisão aborda compostos fitoquímicos, cujo efeito é provado na proteção/regeneração de células beta de pâncreas. Entre centenas de plantas que têm sido investigadas para o diabetes, pequena fração tem mostrado propriedade regenerativa, que será descrita neste trabalho. Os processos de degeneração e de regeneração das células beta do pâncrease são descritos. Além disso, mecanismos propostos para efeitos de proteção e regeneração desses compostos fitoquímicos e seus possíveis efeitos colaterais também serão discutidos neste trabalho.Unitermos: Diabetes mellitus/tratamento. Diabetes mellitus/fitoterapia. Fitoterapia/Diabetes mellitus. Ilhotas/regeneração endógena. Células beta/proteção. Células beta/regeneração. Pâncreas. Plantas medicinais/propriedades regenerativas.

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Evaluation of antidiabetic antihyperlipidemic and pancreatic regeneration, potential of aerial parts of Clitoria ternatea

Cited by 51 publications

References 36 publications

Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts ofVernonia amygdalina: A Comparative Study

Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts ofVernonia amygdalina: A Comparative Study

Antidiabetic and antihyperlipidemic activity of Euphorbia thymifolia L. extracts on streptozotocin-nicotinamide induced type 2 diabetic rats

Pancreatic beta cell protection/regeneration with phytotherapy

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