Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models

Mahesh, Ayyavu; Jeyachandran, R.; Rao, Dowlathabad Muralidhara; Thangadurai, Devarajan

doi:10.1590/s0102-695x2012005000081

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…At higher concentration (150 mg/kg), the plant extract increased protein and glutathione levels significantly. Moreover, concentration-dependent significant reduction was observed in gastric secretion, free acidity and total acid output in extract-trated animals suggesting potential of gastroprotection of plant extract through regeneration of gastric mucosal injury (59).…”

Section: Antiulcer Studymentioning

confidence: 92%

Ethnomedical uses, Phytochemistry, Pharmacological and therapeutic properties of Desmodium gangeticum (L.) DC.: A Scoping Review

et al. 2022

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A surge in laboratory research into the pharmacological properties of bioactive compounds, as well as their potential to cure a wide range of ailments, has resulted in an influx of new herbal medications and extracts onto the international market in recent years. D. gangaticum (L.) (DG), one of the essential herbs of Indian traditional system of medicines is part of many essential formulations viz. "Dashamoola" and is used to treat various diseases. It is a perennial herb, locally known as "Shalparni" (Hindi) in India and also reported in many other tropical countries. This review presents the traditional uses, phytochemistry, pharmacology, and clinical effectiveness of D. gangaticum Literature was systematically searched through various databases, journals and gray literature through electronic and manual search. Collected data was further critically reviewed and summarized in this paper. It contains many bio-active phytochemicals viz. gangeticoside, leonuriside A, tortoside A, dehydrosoyasaponin, gangetin, gangetinin, desmocarpin, desmodin etc. among them, some have drug likeliness properties. Critical literature analysis revealed that it possessed many pharmacological activities viz. anti-inflammatory, antinociceptive, anti- oxidant, cardioprotective, antidiabetic and hepatoprotective anti- bacterial, and anti-amnesic activities. Despite a large number of traditional therapeutic uses, D. gangaticum was evaluated for limited therapeutic efficacy through clinical trials and evidence suggested it may have therapeutic benefits on bronchitis, gout, hypertension. The biochemical and physiological mechanisms involved in the different biological effects exhibited by it need to be investigated. The herb should be investigated further, focusing on pharmacodynamic, pharmacokinetic and safety profiles. Well-designed Randomized Controlled trials (RCTs) should be conducted to support its therapeutic use.

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Section: Antiulcer Studymentioning

confidence: 92%

Ethnomedical uses, Phytochemistry, Pharmacological and therapeutic properties of Desmodium gangeticum (L.) DC.: A Scoping Review

et al. 2022

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“…Plant extracts of Desmodium gangeticum containing tannin, flavonoids, alkaloids, pterocarpens, phospholipids, saponins and steroids have been reported to possess gastro intestinal anti-motility and anti-spasmodic, anti-diarrhoeal, anti-inflammatory, anti-nociceptive activity and gastro protective effect on gastric ulcer. [5] It does the Shamana of Prakupita Samana and Apana Vata, helps to reduce Adhmana, Visuchika and Kharatva, Rukshata in body parts, Punaha Punaha Rava Mala Sarana, Dourbalya and Krushangata.…”

Section: Probable Mode Of Action Of Shalaparnyadi Kwathamentioning

confidence: 99%

A controlled clinical trial to evaluate the efficacy of Shalaparnyadi Kwatha in the management of Vataja Grahani

Harshitha¹,

Rajendra²

2022

J Ayurveda Integr Med Sci

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Background: Current mechanized life, irregular dietary patterns, irregularity in daily practices, junk food indulgence, stressful life, over usage of pesticides and chemicals leads to various gastro intestinal disorders. These factors hamper the digestive capacity of individuals and develop the disease Grahani. Shalaparnyadi Kwatha mentioned in treatment of Vataja Grahani in Sharangadhara Samhita is taken up for study in the management of Vataja Grahani. Objective: To evaluate the efficacy of Shalapanryadi Kwatha in Vataja Grahani. Method: The study was a double arm open labelled controlled clinical trial with pre and post-test study design. There were total of 41 subjects involved in the study and were divided into two groups - Group A (trial group) with 21 subjects and Group B (controlled group) with 20 subjects. Group A was administered with Shalaparnyadhi Kwatha and Panchamooladya Choorna and Group B was administered with Panchamooladya Choorna for 30 consecutive days. Result: A controlled clinical study was conducted on subjects of Vataja Grahani with Shalaparnyadi Kwatha and Panchamooladya Choorna in trial group and Panchamooladya Choorna in control group both the interventions were effective in management of Vataja Grahani. Based on the mean value and statistically significant difference between the groups, trial group showed better result than control group in Amayukta Mala Pravrutti and Udara Shoola. Conclusion: It can be concluded from the results that added effect of Shalaparnyadi Kwatha with Panchamooladya Choorna is more effective than Panchamooladya Choorna alone.

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“…Gastroprotective activity of Desmodium gangeticum has been reported 19 . However, D. triflorum has not been evaluated for its gastroprotective activity In vitro.…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostic Characterization and Antacid Activity of Aqueous Extract of Desmodium triflorum Linn and Pogostemon heyneanus Benth

et al. 2023

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Present study was aimed to investigate the antacid potential of Desmodium triflorum Linn whole plant and Pogostemon heyneanus Benth leaves and to establish their diagnostic characteristics. Powder microscopy, detailed anatomical characteristics, analysis of phytochemicals and Ultra-Performance Liquid Chromatography were done. In addition, neutralizing effects on artificial gastric acid (AGA) by aqueous extracts (AE) of the plants, their ethyl acetate fractions (EAF) and residual aqueous fractions (RAF) were determined. Fordtran’s model (a titration method) was used to evaluate the in vitro neutralization capacity. A modified model of Vatier's artificial stomach was used in the assessment of in vitro acid neutralization duration. Statistical analysis was performed using SPSS 25.0. Pharmacognostic study aids in establishing the standardization parameters. Treatments including AE, RAF of D. triflorum and P. heyneanus showed significant (P<0.01) acid neutralizing effects, duration for consistent neutralization and neutralization capacities. Findings of this study indicated that D. triflorum whole plant and P. heyneanus leaves possessed potent antacid effects.

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Gastroprotective effect of Desmodium gangeticum roots on gastric ulcer mouse models

Cited by 4 publications

References 34 publications

Ethnomedical uses, Phytochemistry, Pharmacological and therapeutic properties of Desmodium gangeticum (L.) DC.: A Scoping Review

Ethnomedical uses, Phytochemistry, Pharmacological and therapeutic properties of Desmodium gangeticum (L.) DC.: A Scoping Review

A controlled clinical trial to evaluate the efficacy of Shalaparnyadi Kwatha in the management of Vataja Grahani

Pharmacognostic Characterization and Antacid Activity of Aqueous Extract of Desmodium triflorum Linn and Pogostemon heyneanus Benth

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