Effect of Woodfordia fruticosa on dexamethasone induced insulin resistance in mice

Bhujbal, Santosh S.; Providencia, Clarine A; Nanda, Rabindra K.; Hadawale, Sunita S.; Yeola, Rupesh R.

doi:10.1590/s0102-695x2012005000020

Cited by 9 publications

(6 citation statements)

References 10 publications

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“…Many factors clarify hyperglycemia after dexamethasone administration, such as decreased insulin sensitivity, attenuated pancreatic α- and β-cell functions, and augmented hepatic gluconeogenesis [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Vitis vinifera Extract Ameliorate Hepatic and Renal Dysfunction Induced by Dexamethasone in Albino Rats

Hasona

Alrashidi

Aldugieman

et al. 2017

Toxics

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This study was conducted to evaluate the biochemical effects of grape seed extract against dexamethasone-induced hepatic and renal dysfunction in a female albino rat. Twenty-eight adult female rats were divided randomly into four equal groups: Group 1: animals were injected subcutaneously with saline and consider as normal control one. Group 2: animals were injected subcutaneously with dexamethasone in a dose of 0.1 mg/kg body weight. Group 3: animals were injected subcutaneously with 0.1 mg/kg body weight of dexamethasone, and then treated with a grape seed extract in a dose of 200 mg/kg body weight by oral gavage. Group 4: animals were injected subcutaneously with 0.1 mg/kg body weight of dexamethasone, and then treated with a grape seed extract in a dose of 400 mg/kg body weight by oral gavage. After 4 weeks, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) activities, albumin, uric acid, creatinine, and glucose levels were assayed. Hepatic reduced glutathione (GSH), total protein content, and catalase and glucose-6-phosphate dehydrogenase activities were also assayed. Dexamethasone administration caused elevation of serum levels of glucose, uric acid, creatinine, ALT, AST activities, and a decrease in other parameters such as hepatic glutathione, total protein levels, and catalase enzyme activity. Treatment with Vitis vinifera L. seed extract showed a significant increase in the body weight of rats in the group treated with Vitis vinifera L. seed extract orally compared with the dexamethasone control group. An increase in GSH and catalase activity in response to oral treatment with Vitis vinifera L. seed extract was observed after treatment. Grape seed extract positively affects glucocorticoid-induced hepatic and renal alteration in albino rats.

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Section: Discussionmentioning

confidence: 99%

Vitis vinifera Extract Ameliorate Hepatic and Renal Dysfunction Induced by Dexamethasone in Albino Rats

Hasona

Alrashidi

Aldugieman

et al. 2017

Toxics

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“…Hyperlipidemia caused in Dex-induced diabetes is due to excess mobilization of fat from the adipose tissue, increase VLDL secretions by the liver and stimulate VLDL formation by the intestine, decreasing hepatic lipoprotein lipase activity that inhibit the removal of plasma VLDL and leading to an increase plasma VLDL level [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effects of parsley, basil, and chicory aqueous extracts against dexamethasone-induced in experimental rats

Soliman¹,

El-Desouky²,

Hozayen³

et al. 2016

J Intercult Ethnopharmacol

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Aim:The objective of this study is to investigate the hypoglycemic, hypolipidemic, and hepatoprotective effects of the aqueous extract of parsley, basil, and chicory whole plant in normal and dexamethasone (Dex) rats.Materials and Methods:50 female albino rats were used in this study and divided into 5 groups (for each 10). Group (1) fed basal diet and maintained as negative control group. Group (2) received Dex in a dose of (0.1 mg/kg b. wt.). Groups 3, 4, and 5 were treated with Dex along with three different plant extracts of parsley, basil, and chicory (2 g/kg b. wt.), (400 mg/kg b. wt.), and (100 mg/kg b. wt.), respectively.Results:All these groups were treated given three times per week for 8 consecutive weeks. Dex-induced alterations in the levels of serum glucose, triglyceride, cholesterol, low-density lipoprotein-cholesterol levels and cardiovascular indices and serum alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase activities, liver thiobarbituric acid (TBARS) levels increased, while high-density lipoprotein-cholesterol, total protein, albumin, and liver glutathione (GSH) levels decreased. On the other hand, plant extracts succeeded to modulate these observed abnormalities resulting from Dex as indicated by the reduction of glucose, cholesterol, TBARS, and the pronounced improvement of the investigated biochemical and antioxidant parameters.Conclusions:It was concluded that probably, due to its antioxidant property, parsley, basil, and chicory extracts have hepatoprotective effects in Dex-induced in rats.

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“…Moreover, phytol as a cholesterol lowering agent, it can be administered clinically to patients with type II diabetes, obesity or other patients in risk of cardiovascular diseases due to elevated cholesterol or triglycerides (patent/WO2009113952A1). In the present study, obese rats declared a noticeable increase in the level of glucose, while a significant reduction in its level in VLPE treated obese rats relative to obese untreated one .Many factors clarify increased level of blood glucose in obesity, such as decreased insulin sensitivity, attenuated pancreatic lipase and cell function, as well as augmented hepatic gluconeogenesis [55,56]. Feeding of excessive cholesterol induces hypercholesterolemia and arteriosclerosis and further elicits the progress of obesity and dyslipidemia in both humans and rodents by changing the levels of plasma cholesterol and triglyceride [57].…”

Section: G2 G4 G5mentioning

confidence: 80%

Anti-obesity efficacy of lipoidal matter of Vitis venifera leaves in rats

et al. 2021

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Background: Obesity is one of the most prevailing health issues globally. Aims: The current study was conducted to evaluate the biochemical effects of Vitis vinifera leaves petroleum ether extract (VLPE) against high-fat diet induced obesity in rats. Methods: VLPE was administrated in a dose 200 mg/kg body weight. Liver enzymes, lipid profile, oxidative stress, apoptotic and inflammatory biomarkers as apelin, paraxonase -1 (PON-1), Nuclear Factor Kappa beta (NFkB), Monocyte chemoattractant protein-1 (MCP 1) and (B-cell lymphoma 2) BCl2 were assayed. Also, glucose, leptin and lipase levels were evaluated. Moreover, the phytochemicals profile of VLPE was characterized through chromatographic and spectroscopic tools after saponification. Results: Post-treatment of obese rats with VLPE, a significant decrease in the bodyweight gain was detected compared control group. In addition, reduction in MDA while an elevation in GSH, apelin and PON1 levels post treatment of obese -rats with VLPE was observed. Also, a noticeable improvement in other parameters was recorded upon treating HFD-rats with VLPE. Post treatment of obese rats with Vitis vinifera; normal histological structure of hepatic lobule with mild inflammatory cells infiltration in the portal area was examined. Kidney of obese rats showed vacuolar degeneration in the epithelial cells lining the tubules, while obese rats treated with Vitis vinifera extract and Orlistat drug showed no vascular congestion and no inflammation. Concerning the characterization of VLPE, twenty-three compounds, as well as fifteen fatty acids, were identified in unsaponifiable and saponifiable fractions, respectively. Unsaponifiable fraction constituted of hydrocarbons (13.86% of total unsaponifiable matter), fatty alcohol (7.20%) and sterol (2.65 %) and triterpene compounds (2.09%). Column chromatography of the USM afforded lupeol, cholesterol, campesterol and -sitosterol in addition one fatty alcohol 1-triacontanol. Conclusion: According to the finding results, a lipoidal matter of Vitis vinifera leaves possesses multi-functional anti-obesity activities that can be used as a phytochemical functional food.

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Effect of Woodfordia fruticosa on dexamethasone induced insulin resistance in mice

Cited by 9 publications

References 10 publications

Vitis vinifera Extract Ameliorate Hepatic and Renal Dysfunction Induced by Dexamethasone in Albino Rats

Vitis vinifera Extract Ameliorate Hepatic and Renal Dysfunction Induced by Dexamethasone in Albino Rats

Hepatoprotective effects of parsley, basil, and chicory aqueous extracts against dexamethasone-induced in experimental rats

Anti-obesity efficacy of lipoidal matter of Vitis venifera leaves in rats

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