Evaluation of anticonvulsant activity of ethanolic leaves extract of Desmodium triflorum in mice

Abstract

The present investigation was aimed to study an anticonvulsant activity of ethanolic extract of Desmodium triflorum (L.) DC., Fabaceae, in mice. Animal models of epilepsy namely the pentylenetetrazole (PTZ), isoniazid or isonicotinic hydrazide (INH) and maximal electroshock induced convulsion (MES) were used to evaluate the anticonvulsant effects of the extracts. The biochemical estimation was done by measuring the lipid peroxidation and reduced glutathione (GSH). In the PTZ induced convulsion, ethanolic extract of D. triflorum (EEDT) 400 mg/kg significant delayed the onset of convulsion, reduced the duration of convulsion and reduced mortality. Similarly a dose of 800 mg/kg of EDDT significantly delayed the onset of convulsion, reduced the duration of convulsion and showed 33.33% protection in mice against INH induced convulsion. Further no mortality was found. Both the doses reduced hind limb tonic extension (HLTE) phase of MES induced convulsion in mice. The pretreated EEDT showed significant inhibition of lipid peroxidation and increases the reduced glutathione level in mice brain tissue. The results revealed that D. triflorum possesses a significant dose dependent anticonvulsant activity.

Assessment of Anticonvulsant Activities of Petroleum Ether Extract of Anacyclus pyrethrum Roots on Experimental Rats

“…Hereby, GS/MS analysis revealed that the plant root is rich in fatty acids such as linoleic acid and palmitic acid; these molecules may contribute to their anticonvulsant activities. Several studies indicated the potential anticonvulsant effects of these polyunsaturated and straightchain fatty acids [28][29][30]. Based on the current research, it is impossible to determine and attribute the anticonvulsant effect to any component.…”

The biological active compounds and biological activities of Desmodium species from Indian region: a review

“…Anthelmintic activity [65] Whole plant parts anti-microbial activity [43] Whole plant Phenolic Flavonoid Antioxidant Help in cardiovascular disease and degenerative diseases Analgesic and anti-inflammatoryproperties [46] anti-inflammatory and Analgesic activities [82] Antioxidant Anti-proliferative [81] Leaves Anticonvulsantactivity [85] Anti-microbial activity [45] anticonvulsant properties [86] 6 Desmodium ramosissimum antifungal and antibacterial activities [51] 7…”

“…Desmodium triflorum is traditionally used as a laxative and dysentery [83], a plant used for fever [66] and plant help to cure bone fracture [84]. Desmodium triflorum ethanolic leaves extract showed anticonvulsant activity [85]. The plant showed anti-microbial activity [45].…”