Phytochemical screening, antinociceptive and anti-inflammatory effects of the essential oil of Myrcia pubiflora in mice

Andrade, Gilmara S.; Guimarães, Adriana Gibara; Santana, Marília T.; Siqueira, Rosana de Souza; Passos, Luiz Oliveira; Machado, Samísia Maria Fernandes; Ribeiro, Adauto de Souza; Sobral, Marcos; Almeida, Jackson Roberto Guedes da Silva; Quintans‐Júnior, Lucindo José

doi:10.1590/s0102-695x2011005000205

Cited by 21 publications

(18 citation statements)

References 27 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mice were divided into five groups of six animals each. The leukocyte migration was induced by injection of carrageenan (1 %, i.p., 0.25 ml) [ 26 ] into the peritoneal cavity of mice 1 h after administration of Av-EtOH (25, 50 and 100 mg/kg, p.o. ), or with saline (p.o.)…”

Section: Methodsmentioning

confidence: 99%

Antinociceptive and anti-inflammatory activities of the ethanolic extract of Annona vepretorum Mart. (Annonaceae) in rodents

Silva

Araújo

Lima-Saraiva

et al. 2015

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundAnnona vepretorum Mart. (Annonaceae) is a native tree from Caatinga (Brazilian Northeastern savanna biome), popularly known as “araticum” and “pinha da Caatinga”. In this study, we investigated the effects of the crude ethanolic extract (Av-EtOH) in models of pain and inflammation in rodents.MethodsThe evaluation of antinociceptive activity was carried out by the acetic acid-induced writhing, formalin, hot plate and tail flick tests, while paw edema induced by carrageenan or histamine, and leukocyte migration to the peritoneal cavity were used for anti-inflammatory profile. Histological analyses also were carried out.ResultsAv-EtOH (25, 50 and 100 mg/kg, p.o) significantly reduced the number of writhing (P < 0.01) and decreased (P < 0.01) the paw licking time in both phases of the formalin test. In the hot plate and tail flick tests, this extract increased the reaction time, consequently reduced painful behavior. The effects in the formalin and hot plate tests were antagonized by naloxone. Av-EtOH inhibited significantly (P < 0.01) the increase in the edema volume after administration of carrageenan and histamine. In the peritonitis test, acute pre-treatment with Av-EtOH inhibited leukocyte migration. Histological analysis showed less inflammation in the groups treated with the extract when the inflammation was induced by carrageenan or histamine.ConclusionThus, Av-EtOH has significant antinociceptive and anti-inflammatory properties, which are related probably with the activation of opioid receptors and inhibition of release of mediators of the inflammatory process. This specie is a potential target for drug discovery.

show abstract

Section: Methodsmentioning

confidence: 99%

Antinociceptive and anti-inflammatory activities of the ethanolic extract of Annona vepretorum Mart. (Annonaceae) in rodents

Silva

Araújo

Lima-Saraiva

et al. 2015

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…The essential oil from the fresh leaves of M. pubiflora (25, 50 and 100 mg/kg) significantly reduced the number of writhing induced by acetic acid and the nociception in the second phase of formalin test; it exhibited inhibitory effect on carrageenan-induced response, it was ineffective inhibiting the time for reaction to thermal stimulus and it did not show any motor performance alterations [34]. …”

Section: Biological and Antioxidant Activities Of The Essential Oimentioning

confidence: 99%

Constituents and Pharmacological Activities of Myrcia (Myrtaceae): A Review of an Aromatic and Medicinal Group of Plants

Cascaes

Guilhon

Andrade

et al. 2015

IJMS

View full text Add to dashboard Cite

Myrcia is one of the largest genera of the economically important family Myrtaceae. Some of the species are used in folk medicine, such as a group known as “pedra-hume-caá” or “pedra-ume-caá” or “insulina vegetal” (insulin plant) that it is used for the treatment of diabetes. The species are an important source of essential oils, and most of the chemical studies on Myrcia describe the chemical composition of the essential oils, in which mono- and sesquiterpenes are predominant. The non-volatile compounds isolated from Myrcia are usually flavonoids, tannins, acetophenone derivatives and triterpenes. Anti-inflammatory, antinociceptive, antioxidant, antimicrobial activities have been described to Myrcia essential oils, while hypoglycemic, anti-hemorrhagic and antioxidant activities were attributed to the extracts. Flavonoid glucosides and acetophenone derivatives showed aldose reductase and α-glucosidase inhibition, and could explain the traditional use of Myrcia species to treat diabetes. Antimicrobial and anti-inflammatory are some of the activities observed for other isolated compounds from Myrcia.

show abstract

“…The leukocyte migration was induced by injection of carrageenan (1%, 0.25 mL, i.p.) in the peritoneal region (Andrade et al, 2012), 1 h after administration of Acs-EtOH (25, 50 and 100 mg/kg, p.o. ), and saline (p.o.)…”

Section: Leukocyte Migration To the Peritoneal Cavitymentioning

confidence: 99%

Antinociceptive and anti-inflammatory activities of ethanolic extract from atemoya (Annona cherimola Mill x Annona squamosa L.)

Silva¹,

Rabêlo²,

Diniz³

et al. 2017

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Atemoya, from family Annonaceae, is an interspecific hybrid between Annona cherimola Mill and Annona squamosa L. It is a tree from a region in diversity of plants, the Caatinga, one of the main Brazilian biomes. In this research, the effects of ethanolic extract of atemoya (Acs-EtOH) were investigated in relief of pain and inflammation in experimental models in rodents. The evaluation of antinociceptive activity was carried out by the acetic acid-induced writhing, formalin and hot plate tests, while air pouch and carrageenan-induced peritonitis were used for anti-inflammatory profile. The motor coordination evaluation was performed by rota-rod test. Acs-EtOH (25, 50 and 100 mg/kg, p.o.) significantly reduced the number of writhes with significant (p < 0.001) and decreased (p < 0.001) paw licking time in both phases of the formalin test. In the hot plate test, the latency was significant, reducing painful stimulus. In the anti-inflammatory models, Acs-EtOH inhibited significantly (p < 0.001) the migration of leukocytes in the air pouch and peritonitis tests. Significant inhibition of migration of leukocytes in the treated groups with different doses of the extract was observed. The results indicate that Acs-EtOH may provide a source of plant compounds with antinociceptive and anti-inflammatory activities.

show abstract

Phytochemical screening, antinociceptive and anti-inflammatory effects of the essential oil of Myrcia pubiflora in mice

Cited by 21 publications

References 27 publications

Antinociceptive and anti-inflammatory activities of the ethanolic extract of Annona vepretorum Mart. (Annonaceae) in rodents

Antinociceptive and anti-inflammatory activities of the ethanolic extract of Annona vepretorum Mart. (Annonaceae) in rodents

Constituents and Pharmacological Activities of Myrcia (Myrtaceae): A Review of an Aromatic and Medicinal Group of Plants

Antinociceptive and anti-inflammatory activities of ethanolic extract from atemoya (Annona cherimola Mill x Annona squamosa L.)

Contact Info

Product

Resources

About