Antinociceptive and anti-inflammatory effects of Caesalpinia pyramidalis in rodents

Abstract

Caesalpinia pyramidalis Tul., Fabaceae, is a plant with an antiinflammatory activity that is used in folk medicine. To evaluate the mechanism of action of this plant, studies were performed on its antinociceptive and antiinflammatory properties using an ethanol extract (EE) made from the inner bark. Oral treatment of mice with the EE (100, 200, and 400 mg/kg) decreased their acetic acid-induced abdominal writhes (p<0.001) and their formalin-induced paw licking in both the first and second phases (p<0.001). This treatment increased the reaction time of mice on the hot-plate test (400 mg/kg, p<0.05); however, it did not alter their performance on the Rotarod performance test. The carrageenan-induced paw edema in the rats and the leukocyte migration into the peritoneal cavity of the mice were also reduced by the EE given at a dose of 400 mg/kg (p<0.05). In addition, the EE (100-400 mg/kg, v.o.) did not alter the arterial pressure of non-anesthetized rats. In conclusion, the EE of C. pyramidalis shows antinociceptive and anti-inflammatory activities in rodents, supporting the usage of this plant to treat various inflammatory diseases for which it has traditionally been used.

Thermal Degradation Kinetics of Kaempferol and Quercetin in the Pre-Formulated of the Standardized Extracts of Poincianella Pyramidalis (Tul.) L. P. Queiroz Obtained by Spray Dryer

“…Several biological activities have already been tested with this species, among which we can highlight the antimicrobial activity against Staphylocus aureus, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Salmonella spp., S. Aureus e Pseudomonas aeruginosa, antioxidant, gastro protective, anti-inflammatory, antinociceptive and anthelmintic activity, which corroborates many of its traditional uses. Due to these proven pharmacological properties, this species has a great potential for the development of a herbal medicine with ample spectrum of action [11][12][13][14][15][16].…”

Traditional use, phytochemistry and biological activities of Poincianella pyramidalys (Tul.) LP Queiroz

“…In addition, the activity of this extract was against carrageenan-induced peritonitis in mice. The extract (400 mg kg -1 ) significantly inhibited the migration of leukocytes into the peritoneal cavity (2.63 ± 0.23 × 106 mL -1 of leukocytes / 80.2% inhibition) compared to the vehicle group (7 22 ± 0.99 × 106 mL -1 of leukocytes) (Santos et al, 2011). Another study was conducted with 90% ethanolic extract of P. pyramidalis to assess the anti-inflammatory activity using Wistar rats with hemorrhagic cystitis.…”

“…In the hot-plate reaction time, the extract (400 mg kg -1 ) increased the pain latency time of mice exposed to the hot plate. The group treated with the extracts did not show any significant effects in the rotarod test (Santos et al, 2011). The possible mechanism of action of ethanol (90%) extract in the nociceptive behavior was investigated by Santos et al (2013a).…”

Development and Validation of High-Performance Liquid Chromatography With Diode Array Detector Method to Analysis of Kaempferol Marker From Extracts of Poincianella Pyramidalis (Tul) L.P Queiroz

“…L.P QUEIROZ is a species belonging to the genus Poincianella Britton & Rose to the family Fabaceae, native to northeastern Brazil region, popularly known as "catingueira [1][2][3]." It is used in folk medicine for the treatment of asthma, bronchitis, diarrhea, gastritis, inflammation, and diabetes [4,5]. Several biological activities were tested with this plant, among which we can highlight the antiinflammatory activities, gastroprotective, antioxidant, anthelmintic, and antimicrobial, thus confirming some of its traditional uses [6][7][8].…”