Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots

Chellappan, David Raj; Joseph, Jipnomon; Balasubramanian, Parimaladevi

doi:10.1590/s0102-695x2011005000168

Cited by 6 publications

(10 citation statements)

References 18 publications

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“…Similarly, Nfambi et al [28] found a significant immunostimulatory effect on both the cell-mediated and humoral immune systems in the Wistar albino rats treated with methanolic leaf extract of M. oleifera. There are other earlier reports supports the present investigation [1,19,23,33,34].…”

Section: Discussionsupporting

confidence: 93%

“…Chellappan et al [23] evaluated the extracts of leaves and roots of C. peltata for physico-chemical, preliminary phytochemical analyses and antioxidant properties. Acute oral toxicity study was conducted as per OECD-423 guidelines and the extract was found to be devoid of any conspicuous acute toxicity in extract treated animals and no mortality up to 2 g/kg by oral route.…”

Section: Discussionmentioning

confidence: 99%

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Phytochemical, antimicrobial, antioxidant and immunomodulatory studies of leaf extracts of Cyclea peltata (Lam.) Hook. f. & Thomson

Bcv¹,

Pr²

2019

GSC Biol. and Pharm. Sci.

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The objective of the present investigation is to study the phytochemical constituents, antimicrobial, antioxidant activity and immunomodulatory effects of Cyclea peltata leaf extract. The fresh whole plants were collected from Kannur, Kerala, India. The crude extract of leaves of C. peltata prepared using methanol and aqueous solvents and were used to investigate the antibacterial activity against Streptococcus mutans, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae by well diffusion method. Antioxidant by DPPH method and immunomodulatory study using Swiss albino rats. The extracts showed the presence of phytoconstituents like tannin, proteins, resins, carbohydrates, alkaloids and terpenoids. Both the extracts showed varying degree of inhibitory potential against all the tested bacteria. Methanol extract of plant had higher inhibitory action against Pseudomonas aeruginosa and Streptococcus mutans. While Staphylococcus aureus showed low sensitivity against aqueous extract of C. peltata. The body weight of the animals showed constant in the case of lower concentration of the drug (1 mg/kg), whereas at higher concentration, the animals showed reduced body weight, with more reduction in highest concentration. Similarly for the organs like liver, the higher dose showed increased mass of liver when compared to lower doses of the drug. The tested animals showed good immunomodulatory effect against the leaf extract. This study further suggests the use of plant extract in treating disease caused by tested microbial organisms.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Phytochemical, antimicrobial, antioxidant and immunomodulatory studies of leaf extracts of Cyclea peltata (Lam.) Hook. f. & Thomson

Bcv¹,

Pr²

2019

GSC Biol. and Pharm. Sci.

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“…Meena and Santhy [ 7 ] demonstrated that administration of a MeOH extract of Cyclea peltata could increase the activities of catalase, superoxide dismutase, and glutathione peroxidase, and decrease the level of malondialdehyde in liver and kidney tissues of Dalton’s Ascites Lymphoma (DAL) mice. Chellappan et al [ 5 ] also found that the hydroalcoholic extract of C. peltata had a good scavenging effect on ABTS free radicals.…”

Section: Discussionmentioning

confidence: 99%

Composition of phenolic compounds and antioxidant attributes of Cyclea gracillima Diels extracts

Lin

Liu

Kuo

et al. 2018

Journal of Food and Drug Analysis

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Cyclea gracillima Diels is a Taiwanese native medicinal herb. However, there are currently few relevant reports on its biochemical activity. In this study, the antioxidant attributes of the ethanol and hot water extracts of this herb were assayed using in vitro models, including the following: 2,2-diphenyl-1-(2,4,6-trinitrophenyl)-hydrazyl radical scavenging, Trolox equivalent antioxidant capacity, reducing power, and chelating ferrous ions. The following biochemical models were also assayed: inhibition of human low density lipoprotein oxidation, inhibition of human erythrocyte hemolysis, and scavenging oxygen radicals in human blood. The composition and content of flavonoids and phenolic acids in these extracts were also analyzed. The results showed that these extracts with high polyphenol levels presented remarkable antioxidant effects in all assays, especially when extracted with ethanol. Six phenolic acids (mainly ferulic acid, sinapic acid, and syringic acid) and 12 flavonoids (mainly narigenin, myricetin, naringin, and apigenin) were found in these extracts.

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“…To ensure the superiority of herbal medicines, appropriate control of starting material is extremely crucial. The first step for assuring quality of starting material is its authentication that may be followed Volume 4 | Number 2 | June | 2014 by developing numerical values of standards for assessment [24,25]. Pharmacognostical evaluation of different parameters is the vital etiquette for standardization of herbals [26].…”

Section: Discussionmentioning

confidence: 99%

Pharmacognostic Investigation of Clerodendrum phlomidis Linn. f. Root

Kumar¹,

Kumar²,

Prakash³

2014

JTLS

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The present study was aimed to perform the pharmacognostic evaluation of Clerodendrum phlomidis Linn. f. root in terms of organoleptic, fluorescence analysis, macro-microscopy and physicochemical parameters. The characteristic macroscopic study showed that the root consists of 7-15 cm long, 0.2 -3.0 cm thick pieces which are cylindrical, tough and yellowish-brown externally, with hard fracture and slightly astringent taste. The main microscopic characters of the root show exfoliating cork, having 10-15 rows of tangentially elongated, thick-walled cells. Cortex consists of round to oval parenchymatous cells, a few containing rhomboid shaped calcium oxalate crystals. Endodermis consists of 3-4 layers of non-lignified, thick-walled rounded parenchymatous cells followed by a single pericyclic layer. Phloem consists of isodiametric, thin-walled, parenchymatous cells whereas xylem contains lignified pitted vessels. Medullary rays consisting of biseriate layer of lignified and radially elongated parenchymatous cells is narrower in the xylem region during wider in the phloem region. The physicochemical analysis of the root, i.e., total ash, water-soluble ash, sulphated ash are 7.8, 0.9 and 10.3 (% w/w) respectively. Further successive extraction of the root powder with petroleum ether, chloroform, alcohol, water yielded 2.2, 2.4, 12.4 and 9.6 (% w/w) extracts respectively. Fluorescence study imparted characteristic colours to the root powder when observed under visible, short and long wavelength light. Various pharmacognostic parameters evaluated in this study helps in botanical identification and standardization of Clerodendrum phlomidis L. root part in crude form and provide the authentic data for the researchers and scientists involved in carrying out further research on this plant part.

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Pharmacognostical, antioxidant and antiulcer screening of Cyclea peltata roots

Cited by 6 publications

References 18 publications

Phytochemical, antimicrobial, antioxidant and immunomodulatory studies of leaf extracts of Cyclea peltata (Lam.) Hook. f. & Thomson

Phytochemical, antimicrobial, antioxidant and immunomodulatory studies of leaf extracts of Cyclea peltata (Lam.) Hook. f. & Thomson

Composition of phenolic compounds and antioxidant attributes of Cyclea gracillima Diels extracts

Pharmacognostic Investigation of Clerodendrum phlomidis Linn. f. Root

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